CAS 329689-23-8: Monastrol

Description: Monastrol is a small molecule inhibitor primarily known for its role in disrupting the function of kinesin-5, a motor protein involved in mitosis. It is characterized by its ability to inhibit cell division by interfering with the proper formation of the mitotic spindle, thereby preventing the correct segregation of chromosomes during cell division. Monastrol is often studied in the context of cancer research, as its mechanism of action can lead to the selective targeting of rapidly dividing cancer cells. The compound is typically described as a white to off-white solid, and it is soluble in organic solvents such as dimethyl sulfoxide (DMSO). Its chemical structure includes specific functional groups that contribute to its biological activity. Monastrol has been utilized in various experimental settings to explore the dynamics of cell division and the potential for therapeutic applications in oncology. As with many chemical substances, safety and handling precautions are essential when working with Monastrol in laboratory settings.

Formula: C₁₄H₁₆N₂O₃S

InChI: InChI=1S/C14H16N2O3S/c1-3-19-13(18)11-8(2)15-14(20)16-12(11)9-5-4-6-10(17)7-9/h4-7,12,17H,3H2,1-2H3,(H2,15,16,20)

InChI key: InChIKey=LOBCDGHHHHGHFA-UHFFFAOYSA-N

SMILES: O=C(OCC)C1=C(NC(=S)NC1C=2C=CC=C(O)C2)C

Synonyms:

• 5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-, ethyl ester
• 5-Pyrimidinecarboxylicacid, 1,2,3,4-tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-, ethyl ester
• 6-Methyl-4-(3-hydroxyphenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester
• 6-Methyl-4-(3-hydroxyphenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylicacid ethyl ester
• Ethyl 1,2,3,4-tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-5-pyrimidinecarboxylate
• Ethyl 4-(3-Hydroxyphenyl)-6-Methyl-2-Thioxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate
• ethyl (4R)-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
• ethyl (4S)-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

5-Pyrimidinecarboxylic acid,1,2,3,4-tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-, ethyl ester

CAS: 329689-23-8

• Formula: C₁₄H₁₆N₂O₃S
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 292.3534

Monastrol

CAS: 329689-23-8

• Purity: ≥98%
• Molecular weight: 292.35g/mol

Ethyl 4-(3-Hydroxyphenyl)-6-Methyl-2-Thioxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate

CAS: 329689-23-8

• Purity: 98%
• Molecular weight: 292.35g/mol

Monastrol

CAS: 329689-23-8

Monastrol ((±)-Monastrol) is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.

• Formula: C₁₄H₁₆N₂O₃S
• Purity: 98.59% - 99.19%
• Color and Shape: Solid
• Molecular weight: 292.35

Monastrol

CAS: 329689-23-8

Applications Monastrol is a small molecule that inhibits mitotic kinesin Eg5 and arrests cells in …

• Formula: C₁₄H₁₆N₂O₃S
• Color and Shape: Neat
• Molecular weight: 292.35

Monastrol, 98%

CAS: 329689-23-8

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. …

• Formula: C₁₄H₁₆N₂O₃S
• Purity: 98%
• Molecular weight: 292.36

Monastrol

CAS: 329689-23-8

Monastrol is a natural compound that has been shown to promote axonal growth in the …

• Formula: C₁₄H₁₆N₂O₃S₂
• Purity: Min. 95%
• Molecular weight: 292.35 g/mol