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CAS 32986-56-4

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Tobramycin

Description:
Tobramycin is an aminoglycoside antibiotic primarily used to treat infections caused by Gram-negative bacteria, particularly Pseudomonas aeruginosa. It is effective against a range of bacterial infections, especially in patients with cystic fibrosis or those with compromised immune systems. The substance is characterized by its ability to inhibit bacterial protein synthesis by binding to the 30S ribosomal subunit, leading to misreading of mRNA and ultimately cell death. Tobramycin is typically administered via inhalation, injection, or topical application, depending on the infection's location and severity. It is known for its relatively low toxicity compared to other aminoglycosides, although it can still cause nephrotoxicity and ototoxicity, necessitating careful monitoring of kidney function and hearing during treatment. The chemical structure of tobramycin includes multiple hydroxyl and amino groups, contributing to its solubility and biological activity. As with all antibiotics, the emergence of resistance is a concern, making appropriate use and adherence to prescribed regimens essential for maintaining its efficacy.
Formula:C18H37N5O9
InChI:InChI=1/C20H41N5O7/c21-5-8-1-7(10(22)4-13(8)27)2-9-11(23)3-12(24)19(16(9)28)32-20-18(30)15(25)17(29)14(6-26)31-20/h7-20,26-30H,1-6,21-25H2
InChI key:InChIKey=NLVFBUXFDBBNBW-PBSUHMDJSA-N
SMILES:O([C@@H]1[C@@H](O)[C@H](O[C@H]2O[C@H](CN)[C@@H](O)C[C@H]2N)[C@@H](N)C[C@H]1N)[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O
Synonyms:
  • (1S,2S,3R,4S,6R)-4,6-diamino-3-[(2,6-diamino-2,3,6-trideoxy-alpha-D-ribo-hexopyranosyl)oxy]-2-hydroxycyclohexyl 3-amino-3-deoxy-alpha-D-glucopyranoside
  • 3'-Deoxykanamycin B
  • 4-Amino-2-[4,6-Diamino-3-[[2-Amino-5-(Aminomethyl)-4-Hydroxy-Cyclohexyl]Methyl]-2-Hydroxy-Cyclohexoxy]-6-(Hydroxymethyl)Tetrahydropyran-3,5-Diol
  • <span class="text-smallcaps">D</smallcap>-Streptamine, O-3-amino-3-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→6)-O-[2,6-diamino-2,3,6-trideoxy-α-<smallcap>D</span>-ribo-hexopyranosyl-(1→4)]-2-deoxy-
  • D-Streptamine, O-3-amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[2,6-diamino- 2,3,6-trideoxy-α-D-ribo-hexopyranosyl-(1→4)]-2-deoxy-
  • Deoxykanamycin B
  • Nebramycin 6
  • Nebramycin VI
  • Nebramycin factor 6
  • Nf 6
  • See more synonyms
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products per page.Found 23 products.
  • Tobramycin (TBM)
    Sisco Research Laboratories
    + Info

    Tobramycin (TBM)

    CAS:
    Formula:C18H37N5O9
    Purity:min. 900 µg/mg
    Color and Shape:White, Powder
    Molecular weight:467.5

    Ref: SR-56183

    50mg
    28.00€
    500mg
    54.00€
  • Tobramycin
    Fluorochem
    + Info

    Tobramycin

    CAS:
    Molecular weight:467.519989

    Ref: 10-F863874

    1g
    20.00€
    5g
    54.00€
    25g
    170.00€
    100g
    499.00€
    100mg
    16.00€
  • Tobramycin, Antibiotic for Culture Media Use Only
    Biosynth
    + Info

    Tobramycin, Antibiotic for Culture Media Use Only

    Controlled Product
    CAS:
    <p>Tobramycin is used to treat severe infections with gram-negative bacteria and it is often applied in combination with beta-lactams. It has similar antimicrobial effects to gentamicin and is effective against all Enterobacteriacae, but more effective than gentamicin against P. aeruginosa, which is why it is often used for gentamicin-resistant strains, especially in the case of cystic fibrosis.</p>
    Formula:C18H37N5O9
    Purity:Min. 97 Area-%
    Molecular weight:467.51 g/mol

    Ref: 3D-Q-201837

    ne
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    10g
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    250g
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    -Unit-gg
    Discontinued
    Discontinued product