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CAS 33008-99-0

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5′-O-Phosphonoguanylyl-(3′→5′)-guanosine

Description:
5′-O-Phosphonoguanylyl-(3′→5′)-guanosine, commonly referred to as 5′-O-phosphono-Guanylyl-(3′→5′)-guanosine, is a nucleotide analog characterized by its unique phosphonate group, which enhances its stability against enzymatic degradation. This compound features a guanosine base linked through a phosphodiester bond to another guanosine, forming a dinucleotide structure. The presence of the phosphonate group imparts increased resistance to hydrolysis, making it a valuable tool in biochemical research and therapeutic applications. It is often utilized in studies involving RNA synthesis, signaling pathways, and as a potential antiviral agent due to its ability to mimic natural nucleotides. The compound is soluble in aqueous solutions, allowing for easy incorporation into various biochemical assays. Its structural characteristics enable it to participate in biochemical reactions similarly to natural nucleotides, while its modifications provide insights into nucleotide function and metabolism. Overall, 5′-O-Phosphonoguanylyl-(3′→5′)-guanosine serves as an important compound in the fields of molecular biology and medicinal chemistry.
Formula:C20H26N10O15P2
InChI:InChI=1S/C20H26N10O15P2/c21-19-25-13-7(15(34)27-19)23-3-29(13)17-10(32)9(31)5(43-17)1-42-47(39,40)45-12-6(2-41-46(36,37)38)44-18(11(12)33)30-4-24-8-14(30)26-20(22)28-16(8)35/h3-6,9-12,17-18,31-33H,1-2H2,(H,39,40)(H2,36,37,38)(H3,21,25,27,34)(H3,22,26,28,35)/t5-,6-,9-,10-,11-,12-,17-,18-/m1/s1
InChI key:InChIKey=ZEHOHLFQOXAZHX-MHARETSRSA-N
SMILES:O[C@H]1[C@H](N2C3=C(N=C2)C(=O)N=C(N)N3)O[C@H](COP(=O)(O)O)[C@H]1OP(OC[C@H]4O[C@H]([C@H](O)[C@@H]4O)N5C6=C(N=C5)C(=O)N=C(N)N6)(=O)O
Synonyms:
  • 5′-O-Phosphonoguanylyl-(3′→5′)-guanosine
  • Guanosine, 5′-O-phosphorylguanylyl-(3′→5′)-
  • 5′-Guanylic acid, guanylyl-(5′→3′)-
  • Guanosine, 5′-O-phosphonoguanylyl-(3′→5′)-
  • 5'-Phosphoguanylyl-(3'->5')-guanosine
  • pGpG
  • 5'-O-Phosphorylguanylyl-(3'-5')-guanosine
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Purity (%)
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100
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50
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90
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95
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100
Found 1 products.
  • 5'-Phosphoguanylyl-(3'->5')-guanosine sodium
    Biosynth
    + Info

    5'-Phosphoguanylyl-(3'->5')-guanosine sodium

    CAS:
    <p>pGpG, linear diguanylate, is the first phosphodiesterase-catalyzed hydrolysis product of cylic di-GMP (c-diGMP). c-diGMP has been identified as a novel second messenger in bacteria that triggers various physiological changes such as virulence gene expression or cell differentiation</p>
    Formula:C20H26N10O15P2·xNa
    Purity:Min. 95 Area-%
    Color and Shape:Powder
    Molecular weight:708.43 g/mol

    Ref: 3D-NP46568

    1mg
    473.00€