CAS 33017-11-7

C-peptide fragment 3-33

Description:

C-peptide fragment 3-33, associated with the CAS number 33017-11-7, is a peptide derived from the proinsulin molecule, specifically from the connecting peptide (C-peptide) region. This fragment consists of amino acids 3 to 33 of the C-peptide sequence, which plays a crucial role in the processing of proinsulin into insulin. C-peptide itself is released into the bloodstream in equimolar amounts with insulin, serving as a useful biomarker for insulin production in the body. The fragment 3-33 is of interest in research related to diabetes and metabolic disorders, as it may have implications for understanding insulin secretion and action. Characteristically, this peptide is hydrophilic, which influences its solubility and interaction with biological systems. It is typically synthesized using solid-phase peptide synthesis techniques and can be analyzed through methods such as mass spectrometry and high-performance liquid chromatography (HPLC). Its biological activity and potential therapeutic applications are subjects of ongoing research, particularly in the context of diabetes management and treatment.

Formula: C₁₂₉H₂₁₁N₃₅O₄₈

Synonyms:

• Proinsulin C-peptide (human)
• C-Peptide, Proinsulin
• Human proinsulin C-peptide

C-Peptide (human)

CAS: 33017-11-7

Bachem ID: 4068086.

Formula: C₁₂₉H₂₁₁N₃₅O₄₈

Purity: 96.0%

Color and Shape: White Lyophilisate

Molecular weight: 3020.3

Ref: 01-4068086

C-Peptide (human)

CAS: 33017-11-7

The measurement of the C-peptide under standardized conditions provides a sensitive, well accepted, and clinically validated assessment of β-cell function. The C-peptide measurement is the most suitable primary outcome for clinical trials of therapies aimed at preserving or improving endogenous insulin secretion in type 1 diabetes patients. C-peptide also shows hormonal activity. Clinical studies demonstrated that C-peptide administration in type 1 diabetes patients, who lack the peptide, alleviates the diabetes-induced renal and nerve dysfunctions.

Formula: C₁₂₉H₂₁₁N₃₅O₄₈

Purity: 96.2%

Color and Shape: White

Molecular weight: 3020.3

Ref: 01-4009494

Proinsulin C-peptide (human)

CAS: 33017-11-7

C-peptide, a 31-amino acid, links Proinsulin A & B chains for correct folding and function.

Formula: C₁₂₉H₂₁₁N₃₅O₄₈

Purity: 98%

Color and Shape: Solid

Molecular weight: 3020.26

Ref: TM-TP1651

Proinsulin C-peptide (human)

CAS: 33017-11-7

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Formula: C₁₂₉H₂₁₁N₃₅O₄₈

Molecular weight: 3,020.26 g/mol

Ref: 3D-PP49951

C-Peptide (Human)

CAS: 33017-11-7

C-peptide is a peptide hormone that is cleaved from proinsulin in the pancreatic beta cells. Both C-peptide and insulin are released by the beta cells in the event of glycaemia. Due to it having a relatively long half life, compared to insulin, and the fact it is not immediately metabolised by the liver, makes C-peptide a useful biomarker to monitor beta cell function. Increased levels of C-peptide occurring in patients with insulin resistant type 2 diabetes mellitus, have been associated with macrovascular complications and cardiovascular morbidity. During in vitro studies it has also been found that C-peptide prevents endothelial cell reactive oxygen species from being formed and therefore oxidative stress is reduced. This also may lead to anti-inflammatory and anti-apoptotic responses.

Formula: C₁₂₉H₂₁₁N₃₅O₄₈

Purity: Min. 95%

Molecular weight: 3,020.27 g/mol

Ref: 3D-PCP-3725-PI

C-Peptide (human) acetate salt

CAS: 33017-11-7

C-Peptide (human) acetate salt H-Glu-Ala-Glu-Asp-Leu-Gln-Val-Gly-Gln-Val-Glu-Leu-Gly-Gly-Gly-Pro-Gly-Ala -Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Pro Leu Ala is a peptide that has been purified from the pancreas of human and bovine sources. It is used in blood sampling and rate constant experiments to measure the response element on a signal peptide. This experiment can be used to study insulin production, as well as other biological samples. C Peptide (human) acetate salt H Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu Ala has inhibitory properties against

Formula: C₁₂₉H₂₁₁N₃₅O₄₈

Purity: Min. 95%

Molecular weight: 3,020.26 g/mol

Ref: 3D-FP110235

C-Peptide (human) trifluoroacetate salt

CAS: 33017-11-7

C-Peptide is a monoclonal antibody that binds to the β-cell and inhibits insulin release. It has been used in diagnosis of type 1 diabetes mellitus. C-Peptide is a hormone that regulates blood glucose levels by controlling the rate of glucose production in the liver, as well as by inhibiting the breakdown of glycogen in the liver. The C-terminal amino acid sequence Glu-Ala-Glu-Asp-Leu-Gln-Val-Gly-Gln-Val-Glu -Leu-Gly can be cleaved from the peptide by trifluoroacetic acid to yield free Gln, which can then be detected using mass spectrometry. Growth factors such as IGF1, FGF21, and HGF have been shown to increase C peptide levels in diabetic patients.

Formula: C₁₂₉H₂₁₁N₃₅O₄₈

Purity: Min. 95%

Molecular weight: 3,020.26 g/mol

Ref: 3D-FP108679