CAS 330628-04-1

2'-Deoxy-N2-DMF-5'-O-DMT-guanosine 3'-CE phosphoramidite

Description:

2'-Deoxy-N2-DMF-5'-O-DMT-guanosine 3'-CE phosphoramidite is a modified nucleoside analog used primarily in the synthesis of oligonucleotides. This compound features a deoxyribose sugar, which is characteristic of DNA nucleotides, and is modified at the N2 position of the guanine base with a dimethylformamide (DMF) moiety, enhancing its solubility and stability during synthesis. The 5'-O-DMT (dimethoxytrityl) group serves as a protecting group, allowing for selective reactions during oligonucleotide assembly. The 3'-CE (cyanoethyl) phosphoramidite functionality is crucial for the formation of phosphodiester bonds, facilitating the incorporation of this nucleotide into growing DNA strands. This compound is typically utilized in automated synthesizers for the production of custom DNA sequences, making it valuable in research, diagnostics, and therapeutic applications. Its stability, solubility, and reactivity profile are essential for efficient oligonucleotide synthesis, contributing to advancements in molecular biology and genetic engineering.

Formula: C₄₃H₅₃N₈O₇P

Synonyms:

• DMF-dG Phosphoramidite
• N2-Dimethylfromamidine-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine-3'-cyanoethyl Phosphoramidite

Dmf-dg phosphoramidite

CAS: 330628-04-1

Formula: C₄₃H₅₃N₈O₇P

Purity: 98%

Color and Shape: Solid

Molecular weight: 824.9041

Ref: IN-DA00I6DC

Dmt-Dg(Dmf) Amidite

CAS: 330628-04-1

Dmt-Dg(Dmf) Amidite

Purity: 98%

Molecular weight: 824.9g/mol

Ref: 54-OR1029734

2''-Deoxy-N2-DMF-5''-O-DMT-guanosine 3''-CE phosphoramidite

CAS: 330628-04-1

Formula: C₄₃H₅₃N₈O₇P

Purity: (HPLC) ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 824.90

Ref: 7W-GN8308

DMT-dG(dmf) Phosphoramidite

CAS: 330628-04-1

DMT-dG(dmf) Phosphoramidite is a phosphinamide monomer employed for oligonucleotide synthesis.

Formula: C₄₃H₅₃N₈O₇P

Color and Shape: Solid

Molecular weight: 824.9

Ref: TM-T36755

2'-Deoxy-N2-DMF-5'-O-DMT-guanosine 3'-CE phosphoramidite

CAS: 330628-04-1

2'-Deoxy-N2-DMF-5'-O-DMT-guanosine 3'-CE phosphoramidite is a nucleoside analog with antiviral and anticancer activity. It is synthesized by the coupling of 2'-deoxy-N2,5'-O-dimethoxytrityl guanosine (DMF) monophosphate to 5'-O-dimethoxytrityl cytidine monophosphate (DMT). This compound has been shown to inhibit HIV replication in vitro and in vivo. It has also been shown to have an antiangiogenic effect, which may be due to its ability to inhibit the production of vascular endothelial growth factor (VEGF).

Formula: C₄₃H₅₃N₈O₇P

Purity: Min. 98.0 Area-%

Color and Shape: Powder

Molecular weight: 824.93 g/mol

Ref: 3D-PD09309

DMT-dG(dmf) Phosphoramidite

CAS: 330628-04-1

Purity: 97%

Molecular weight: 824.92

Ref: 10-F987935

DMT-dG(dmf) Phosphoramidite

CAS: 330628-04-1

Formula: C₄₃H₅₃N₈O₇P

Molecular weight: 824.92

Ref: ST-EA-CP-A88113