CAS 330628-04-1
:2'-Deoxy-N2-DMF-5'-O-DMT-guanosine 3'-CE phosphoramidite
Description:
2'-Deoxy-N2-DMF-5'-O-DMT-guanosine 3'-CE phosphoramidite is a modified nucleoside analog used primarily in the synthesis of oligonucleotides. This compound features a deoxyribose sugar, which is characteristic of DNA nucleotides, and is modified at the N2 position of the guanine base with a dimethylformamide (DMF) moiety, enhancing its solubility and stability during synthesis. The 5'-O-DMT (dimethoxytrityl) group serves as a protecting group, allowing for selective reactions during oligonucleotide assembly. The 3'-CE (cyanoethyl) phosphoramidite functionality is crucial for the formation of phosphodiester bonds, facilitating the incorporation of this nucleotide into growing DNA strands. This compound is typically utilized in automated synthesizers for the production of custom DNA sequences, making it valuable in research, diagnostics, and therapeutic applications. Its stability, solubility, and reactivity profile are essential for efficient oligonucleotide synthesis, contributing to advancements in molecular biology and genetic engineering.
Formula:C43H53N8O7P
InChI:InChI=1S/C43H53N8O7P/c1-29(2)51(30(3)4)59(56-24-12-23-44)58-36-25-38(50-28-45-39-40(50)47-42(48-41(39)52)46-27-49(5)6)57-37(36)26-55-43(31-13-10-9-11-14-31,32-15-19-34(53-7)20-16-32)33-17-21-35(54-8)22-18-33/h9-11,13-22,27-30,36-38H,12,24-26H2,1-8H3,(H,47,48,52)/b46-27+/t36-,37+,38+,59?/m0/s1
InChI key:YRQAXTCBMPFGAN-UNHDIWNRSA-N
SMILES:CC(C)N(C(C)C)P(OCCC#N)O[C@H]1C[C@@H](O[C@@H]1COC(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)C4=CC=C(C=C4)OC)N5C=NC6=C5N=C(NC6=O)/N=C/N(C)C
Synonyms:- DMF-dG Phosphoramidite
- N2-Dimethylfromamidine-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine-3'-cyanoethyl Phosphoramidite
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2''-Deoxy-N2-DMF-5''-O-DMT-guanosine 3''-CE phosphoramidite
CAS:Formula:C43H53N8O7PPurity:(HPLC) ≥ 98.0%Color and Shape:White to off-white powderMolecular weight:824.90DMT-dG(dmf) Phosphoramidite
CAS:DMT-dG(dmf) Phosphoramidite is a phosphinamide monomer employed for oligonucleotide synthesis.Formula:C43H53N8O7PColor and Shape:SolidMolecular weight:824.9DMF-DG PHOSPHORAMIDITE
CAS:Formula:C43H53N8O7PPurity:97%Color and Shape:SolidMolecular weight:824.90412'-Deoxy-N2-DMF-5'-O-DMT-guanosine 3'-CE phosphoramidite
CAS:2'-Deoxy-N2-DMF-5'-O-DMT-guanosine 3'-CE phosphoramidite is a nucleoside analog with antiviral and anticancer activity. It is synthesized by the coupling of 2'-deoxy-N2,5'-O-dimethoxytrityl guanosine (DMF) monophosphate to 5'-O-dimethoxytrityl cytidine monophosphate (DMT). This compound has been shown to inhibit HIV replication in vitro and in vivo. It has also been shown to have an antiangiogenic effect, which may be due to its ability to inhibit the production of vascular endothelial growth factor (VEGF).Formula:C43H53N8O7PPurity:Min. 98.0 Area-%Color and Shape:PowderMolecular weight:824.93 g/molDMT-dG(dmf) Phosphoramidite
CAS:(2R,3S,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-(((dimethylamino)methylene)amino)-6-oxo-3H-purin-9(6H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramiditeFormula:C43H53N8O7PPurity:98%Molecular weight:824.9
