CAS 33069-62-4

Paclitaxel

Description:

Paclitaxel, with the CAS number 33069-62-4, is a complex natural product and a chemotherapeutic agent primarily used in the treatment of various cancers, including ovarian, breast, and lung cancer. It is derived from the bark of the Pacific yew tree (Taxus brevifolia) and is classified as a taxane. Paclitaxel functions by stabilizing microtubules and preventing their depolymerization, which disrupts the normal process of cell division, ultimately leading to apoptosis in cancer cells. The compound is characterized by its unique structure, which includes a taxane ring system and several functional groups that contribute to its biological activity. Paclitaxel is typically administered intravenously and has a relatively low solubility in water, often requiring formulation with solvents like Cremophor EL for clinical use. Its side effects can include neutropenia, hypersensitivity reactions, and peripheral neuropathy. Due to its efficacy and mechanism of action, paclitaxel remains a cornerstone in oncological therapies, although its use is often accompanied by careful monitoring and supportive care.

Formula: C₄₇H₅₁NO₁₄

InChI: InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1

InChI key: InChIKey=RCINICONZNJXQF-MZXODVADSA-N

SMILES: O(C(C)=O)[C@]12[C@]3([C@H](OC(=O)C4=CC=CC=C4)[C@@]5(O)C(C)(C)C([C@@H](OC(C)=O)C(=O)[C@]3(C)[C@@H](O)C[C@]1(OC2)[H])=C(C)[C@@H](OC([C@@H]([C@@H](NC(=O)C6=CC=CC=C6)C7=CC=CC=C7)O)=O)C5)[H]

Synonyms:

• 5β,20-Epoxy-1,2a,4,7β,10β,13α-hexahydroxy-tax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
• 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
• 7,11-Methano-5H-Cyclodeca[3,4]Benz[1,2-B]Oxete Benzenepropanoic Acid Deriv.
• Abi 007
• Abraxane
• Anzatax
• Apealea
• Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
• Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-
• Bms 181339-01
• Capxol
• Coroflex Please
• Cremophor-free paclitaxel
• Cyclopax
• Cynviloq
• Cypher select
• Dhp 107
• Ebetaxel
• EmPAC
• EndoTAG 1
• Genaxol
• Genetaxyl
• Genexol
• Genexol-PM
• Ig 001
• Ig 002
• Infinnium
• Intaxel
• Lep-Etu
• Liposome-entrapped paclitaxel easy-to-use
• Mbt 0206
• Mitotax
• Nab-paclitaxel
• Nanotax
• Nanoxel
• Nk 105
• Nsc 125973
• OncoGel
• Onxal
• Oraxol
• Pacitaxel
• Pacliex
• Padexol
• Paxene
• Pazenir
• Plaxicel
• Qw 8184
• Sindaxel
• TAXUS Express
• TAXUS stent
• Tax-11-en-9-one, 5β,20-epoxy-1,2α,4,7β,10β,13α-hexahydroxy-, 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
• TaxAlbin
• Taxal
• Taxol
• Taxol A
• Taxus
• Taxus Liberte
• Tocosol Paclitaxel

Paclitaxel-13C6

Controlled Product

CAS: 33069-62-4

Applications Paclitaxel-13C is the labeled analogue of Paclitaxel (P132500). Paclitaxel is an antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy.
References Letourneau, P.C., et al.: J. Cell Biol., 98, 1355 (1984), Manfredi, J.J., et al.: Pharmacol. Ther., 25, 83 (1984), Danesi, R., et al.: Mol. Pharmacol., 47, 1106 (1995), Markman, M., et al.: Expert. Opin. Pharmacother., 3, 755 (2002), Stone, G.W., et al.: N. Engl. J. Med., 350, 221 (2004),

Formula: C₄₁₁₃C₆H₅₁NO₁₄

Color and Shape: Neat

Molecular weight: 859.86

Ref: TR-P132504

Paclitaxel

CAS: 33069-62-4

Applications An antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy.
References Letourneau, P.C., et al.: J. Cell Biol., 98, 1355 (1984), Manfredi, J.J., et al.: Pharmacol. Ther., 25, 83 (1984), Danesi, R., et al.: Mol. Pharmacol., 47, 1106 (1995), Markman, M., et al.: Expert. Opin. Pharmacother., 3, 755 (2002), Stone, G.W., et al.: N. Engl. J. Med., 350, 221 (2004),

Formula: C₄₇H₅₁NO₁₄

Color and Shape: Neat

Molecular weight: 853.91

Ref: TR-P132500

Paclitaxel

CAS: 33069-62-4

Tubulin ligand which promotes microtubule assembly and stabilises microtubule cytoskeleton against depolymerisation. The compound has anti-tumoral activity since its interference with cytoskeleton dynamics affects the assembly of mitotic spindle, segregation of chromosomes, cell division and blocks the cell cycle in G1 or M phase. The compound is also used for the purification of tubulin or microtubule-associated proteins.

Formula: C₄₇H₅₁NO₁₄

Purity: Min. 95%

Color and Shape: White Clear Liquid

Molecular weight: 853.91 g/mol

Ref: 3D-FP10637

Paclitaxel in Methanol

CAS: 33069-62-4

Methanol

Ref: BE-BePure-GBW(E)086486-1000

Paclitaxel in Methanol

CAS: 33069-62-4

Methanol

Ref: BE-BePure-GBW(E)086485-100

Paclitaxel

CAS: 33069-62-4

Ref: BE-RMCP002000

Paclitaxel (Taxol, PCXL), 99%

CAS: 33069-62-4

Formula: C₄₇H₅₁NO₁₄

Purity: min. 99%

Color and Shape: White, Powder

Molecular weight: 853.91

Ref: SR-42883

Paclitaxel

CAS: 33069-62-4

Tubulin ligand which promotes microtubule assembly and stabilises microtubule cytoskeleton against depolymerisation. The compound has anti-tumoral activity since its interference with cytoskeleton dynamics affects the assembly of mitotic spindle, segregation of chromosomes, cell division and blocks the cell cycle in G1 or M phase. The compound is also used for the purification of tubulin or microtubule-associated proteins.

Formula: C₄₇H₅₁NO₁₄

Purity: Min. 96.0 Area-%

Molecular weight: 853.91 g/mol

Ref: 3D-Q-201533