CAS 330784-47-9
:Avanafil
Description:
Avanafil is a selective phosphodiesterase type 5 (PDE5) inhibitor primarily used for the treatment of erectile dysfunction. It is characterized by its rapid onset of action, typically within 15 to 30 minutes after administration, making it a popular choice among patients seeking quick relief. The chemical structure of avanafil includes a pyrazolo[3,4-d]pyrimidine core, which contributes to its pharmacological activity. It has a high affinity for the PDE5 enzyme, leading to increased levels of cyclic guanosine monophosphate (cGMP) in the corpus cavernosum, facilitating penile erection in response to sexual stimulation. Avanafil is generally well-tolerated, with a side effect profile that may include headaches, flushing, nasal congestion, and back pain. It is important to note that avanafil should not be used in conjunction with nitrates due to the risk of significant hypotension. As with any medication, it is essential for patients to consult healthcare professionals for appropriate usage and potential interactions.
Formula:C23H26ClN7O3
InChI:InChI=1S/C23H26ClN7O3/c1-34-19-6-5-15(10-18(19)24)11-27-21-17(22(33)28-13-20-25-7-3-8-26-20)12-29-23(30-21)31-9-2-4-16(31)14-32/h3,5-8,10,12,16,32H,2,4,9,11,13-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m0/s1
InChI key:InChIKey=WEAJZXNPAWBCOA-INIZCTEOSA-N
SMILES:C(O)[C@H]1N(C=2N=C(NCC3=CC(Cl)=C(OC)C=C3)C(C(NCC=4N=CC=CN4)=O)=CN2)CCC1
Synonyms:- (S)-2-(2-Hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylamino)-5-[(2-pyrimidinylmethyl)carbamoyl]pyrimidine
- (S)-2-(2-Hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylamino)-5-[N-(2-pyrimidinylmethyl)carbamoyl]pyrimidine
- (S)-4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide
- 4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide
- 4-[(3-chloro-4-methoxybenzyl)amino]-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide
- 4-[[(3-Chloro-4-methoxyphenyl)methyl]amino]-2-[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide
- 5-Pyrimidinecarboxamide, 4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-2-[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-
- Spedra
- Ta 1790
- Avanafil
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Found 20 products.
(S)-2-(2-Hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylamino)-5-[(2-pyrimidinylmethyl)carbamoyl]pyrimidine
CAS:Formula:C23H26ClN7O3Purity:98%Color and Shape:SolidMolecular weight:483.9506Ref: IN-DA0034HA
1g35.00€5g73.00€10g111.00€15g157.00€25g177.00€50g325.00€100g701.00€250gTo inquire100mg24.00€250mg25.00€4-[(3-Chloro-4-methoxybenzyl)amino]-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide
CAS:<p>4-[(3-Chloro-4-methoxybenzyl)amino]-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide</p>Purity:98%Molecular weight:483.95064g/molAvanafil 100 µg/mL in Acetonitrile:Dimethylsulfoxide
CAS:Formula:C23H26ClN7O3Color and Shape:Single SolutionMolecular weight:483.95Avanafil
CAS:Formula:C23H26ClN7O3Purity:>98.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:483.96Avanafil
CAS:<p>Avanafil (TA1790) is a selective inhibitor of phosphodiesterase type 5 (PDE5) and is used as therapy of erectile dysfunction.</p>Formula:C23H26ClN7O3Purity:99.03% - >99.99%Color and Shape:White SolidMolecular weight:483.95Avanafil
CAS:Formula:C23H26ClN7O3Purity:≥ 98.0% (dried basis)Color and Shape:White to off-white crystalline powderMolecular weight:483.95Avanafil
CAS:Controlled Product<p>Applications A phosphodiesterase (PDE5) inhibitor, used to treat erectile dysfunction.<br>References Hatzimouratidis, K., et al.: Drugs, 68, 231 (2008);<br></p>Formula:C23H26ClN7O3Color and Shape:WhiteMolecular weight:483.95Avanafil - Bio-X ™
CAS:<p>Avanafil is a phosphodiesterase-5 (PDE5) inhibitor drug that can be used as a treatment for male erectile dysfunction. It works by inhibiting the production of PDE5, which is an enzyme that regulates the levels of cGMP in the penis. Elevated levels of cGMP, results in an increase of blood flow to the penis.</p>Formula:C23H26ClN7O3Purity:Min. 95%Color and Shape:PowderMolecular weight:483.95 g/molAvanafil
CAS:<p>Avanafil is a drug that can be used as a treatment for male erectile dysfunction. It works by inhibiting the production of PDE5, which is an enzyme that regulates the levels of cGMP in the penis. Avanafil has been shown to be effective when taken at a dose of 100 mg; this is because it takes about 30 minutes for avanafil to reach its peak level. Avanafil has a chemical stability that is greater than 12 hours, with an average lifespan of 24 hours. The drug also has no major drug interactions and does not inhibit any other drugs from working.</p>Formula:C23H26ClN7O3Purity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:483.95 g/molAvanafil-13C-d3
CAS:Controlled ProductFormula:CC23D3H25ClN7O2Color and Shape:NeatMolecular weight:485.989Avanafil-d5
CAS:Controlled Product<p>Applications Unlabeled compound, Avanafil (A794670), is a phosphodiesterase (PDE5) inhibitor, used to treat erectile dysfunction.<br>References Hatzimouratidis, K., et al.: Drugs, 68, 231 (2008);<br></p>Formula:C23H21D5ClN7O3Color and Shape:NeatMolecular weight:488.98
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