CAS 330784-47-9: Avanafil

Description: Avanafil is a selective phosphodiesterase type 5 (PDE5) inhibitor primarily used for the treatment of erectile dysfunction. It is characterized by its rapid onset of action, typically within 15 to 30 minutes after administration, making it a popular choice among patients seeking quick relief. The chemical structure of avanafil includes a pyrazolo[3,4-d]pyrimidine core, which contributes to its pharmacological activity. It has a high affinity for the PDE5 enzyme, leading to increased levels of cyclic guanosine monophosphate (cGMP) in the corpus cavernosum, facilitating penile erection in response to sexual stimulation. Avanafil is generally well-tolerated, with a side effect profile that may include headaches, flushing, nasal congestion, and back pain. It is important to note that avanafil should not be used in conjunction with nitrates due to the risk of significant hypotension. As with any medication, it is essential for patients to consult healthcare professionals for appropriate usage and potential interactions.

Formula: C₂₃H₂₆ClN₇O₃

InChI: InChI=1S/C23H26ClN7O3/c1-34-19-6-5-15(10-18(19)24)11-27-21-17(22(33)28-13-20-25-7-3-8-26-20)12-29-23(30-21)31-9-2-4-16(31)14-32/h3,5-8,10,12,16,32H,2,4,9,11,13-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m0/s1

InChI key: InChIKey=WEAJZXNPAWBCOA-INIZCTEOSA-N

SMILES: O=C(NCC1=NC=CC=N1)C2=CN=C(N=C2NCC3=CC=C(OC)C(Cl)=C3)N4CCCC4CO

Synonyms:

• (S)-2-(2-Hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylamino)-5-[(2-pyrimidinylmethyl)carbamoyl]pyrimidine
• (S)-2-(2-Hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylamino)-5-[N-(2-pyrimidinylmethyl)carbamoyl]pyrimidine
• (S)-4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide
• 4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide
• 4-[(3-chloro-4-methoxybenzyl)amino]-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide
• 4-[[(3-Chloro-4-methoxyphenyl)methyl]amino]-2-[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide
• 5-Pyrimidinecarboxamide, 4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-2-[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-
• Spedra
• Ta 1790
• Avanafil

(S)-2-(2-Hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylamino)-5-[(2-pyrimidinylmethyl)carbamoyl]pyrimidine

CAS: 330784-47-9

• Formula: C₂₃H₂₆ClN₇O₃
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 483.9506

Avanafil

CAS: 330784-47-9

• Purity: 99.66%
• Molecular weight: 483.95g/mol

Avanafil-13C-d3

CAS: 330784-47-9

• Formula: C₂₂₁₃CH₂₃D₃ClN₇O₃
• Color and Shape: White To Off-White Solid
• Molecular weight: 487.97

Avanafil

CAS: 330784-47-9

• Formula: C₂₃H₂₆ClN₇O₃
• Color and Shape: White To Off-White Solid
• Molecular weight: 483.96

4-[(3-Chloro-4-methoxybenzyl)amino]-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide

CAS: 330784-47-9

• Purity: 98%
• Molecular weight: 483.95g/mol

Avanafil Impurity 12

CAS: 330784-47-9

• Formula: C₂₈H₃₀ClN₉O₃
• Color and Shape: Off-White Solid
• Molecular weight: 576.06

Avanafil

CAS: 330784-47-9

• Formula: C₂₃H₂₆ClN₇O₃
• Color and Shape: Neat
• Molecular weight: 483.95

Avanafil

CAS: 330784-47-9

• Formula: C₂₃H₂₆ClN₇O₃
• Purity: >98.0%(T)(HPLC)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 483.96

Avanafil 100 µg/mL in Acetonitrile:Dimethylsulfoxide

CAS: 330784-47-9

• Formula: C₂₃H₂₆ClN₇O₃
• Color and Shape: Single Solution
• Molecular weight: 483.95

Avanafil

CAS: 330784-47-9

• Formula: C₂₃H₂₆ClN₇O₃
• Color and Shape: Neat
• Molecular weight: 483.95

Avanafil Impurity 15

CAS: 330784-47-9

• Formula: C₂₄H₂₄ClN₇O₄
• Molecular weight: 509.96

Avanafil

CAS: 330784-47-9

• Formula: C₂₃H₂₆ClN₇O₃
• Purity: ≥ 98.0% (dried basis)
• Color and Shape: White to off-white crystalline powder
• Molecular weight: 483.95

Avanafil-d5

CAS: 330784-47-9

• Formula: C₂₃H₂₁D₅ClN₇O₃
• Molecular weight: 488.99

Aucubin Impurity 1

CAS: 330784-47-9

• Formula: C₂₇H₃₄O₁₅
• Molecular weight: 598.55

Avanafil

CAS: 330784-47-9

Avanafil (TA1790) is a selective inhibitor of phosphodiesterase type 5 (PDE5) and is used as …

• Formula: C₂₃H₂₆ClN₇O₃
• Purity: 98% - 99.03%
• Color and Shape: White Solid
• Molecular weight: 483.95

Avanafil

CAS: 330784-47-9

Applications A phosphodiesterase (PDE5) inhibitor, used to treat erectile dysfunction. References Hatzimouratidis, K., et al.: …

• Formula: C₂₃H₂₆ClN₇O₃
• Color and Shape: White
• Molecular weight: 483.95

Avanafil

CAS: 330784-47-9

Please enquire for more information about Avanafil including the price, delivery time and more detailed …

• Formula: C₂₃H₂₆ClN₇O₃
• Purity: Min. 98 Area-%
• Color and Shape: White Powder
• Molecular weight: 483.95 g/mol

Avanafil - Bio-X ™

CAS: 330784-47-9

Avanafil is a phosphodiesterase-5 (PDE5) inhibitor drug that can be used as a treatment for …

• Formula: C₂₃H₂₆ClN₇O₃
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 483.95 g/mol

Avanafil-d5

CAS: 330784-47-9

Applications Unlabeled compound, Avanafil (A794670), is a phosphodiesterase (PDE5) inhibitor, used to treat erectile dysfunction. …

• Formula: C₂₃H₂₁D₅ClN₇O₃
• Color and Shape: Neat
• Molecular weight: 488.98

Avanafil-13C-d3

CAS: 330784-47-9

• Formula: CC₂₃D₃H₂₅ClN₇O₂
• Color and Shape: Neat
• Molecular weight: 485.989