CAS 330784-47-9

Avanafil

Description:

Avanafil is a selective phosphodiesterase type 5 (PDE5) inhibitor primarily used for the treatment of erectile dysfunction. It is characterized by its rapid onset of action, typically within 15 to 30 minutes after administration, making it a popular choice among patients seeking quick relief. The chemical structure of avanafil includes a pyrazolo[3,4-d]pyrimidine core, which contributes to its pharmacological activity. It has a high affinity for the PDE5 enzyme, leading to increased levels of cyclic guanosine monophosphate (cGMP) in the corpus cavernosum, facilitating penile erection in response to sexual stimulation. Avanafil is generally well-tolerated, with a side effect profile that may include headaches, flushing, nasal congestion, and back pain. It is important to note that avanafil should not be used in conjunction with nitrates due to the risk of significant hypotension. As with any medication, it is essential for patients to consult healthcare professionals for appropriate usage and potential interactions.

Formula: C₂₃H₂₆ClN₇O₃

InChI: InChI=1S/C23H26ClN7O3/c1-34-19-6-5-15(10-18(19)24)11-27-21-17(22(33)28-13-20-25-7-3-8-26-20)12-29-23(30-21)31-9-2-4-16(31)14-32/h3,5-8,10,12,16,32H,2,4,9,11,13-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m0/s1

InChI key: InChIKey=WEAJZXNPAWBCOA-INIZCTEOSA-N

SMILES: C(O)[C@H]1N(C=2N=C(NCC3=CC(Cl)=C(OC)C=C3)C(C(NCC=4N=CC=CN4)=O)=CN2)CCC1

Synonyms:

• (S)-2-(2-Hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylamino)-5-[(2-pyrimidinylmethyl)carbamoyl]pyrimidine
• (S)-2-(2-Hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylamino)-5-[N-(2-pyrimidinylmethyl)carbamoyl]pyrimidine
• (S)-4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide
• 4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide
• 4-[(3-chloro-4-methoxybenzyl)amino]-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide
• 4-[[(3-Chloro-4-methoxyphenyl)methyl]amino]-2-[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide
• 5-Pyrimidinecarboxamide, 4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-2-[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-
• Spedra
• Ta 1790
• Avanafil

Avanafil-13C-d3

Controlled Product

CAS: 330784-47-9

Formula: CC₂₃D₃H₂₅ClN₇O₂

Color and Shape: Neat

Molecular weight: 485.989

Ref: TR-A794674

Avanafil

CAS: 330784-47-9

Formula: C₂₃H₂₆ClN₇O₃

Molecular weight: 484

Ref: ST-EA-CP-A84000