CAS 330936-70-4

(Gly14)-Humanin (Human)

Description:

(Gly14)-Humanin is a peptide derived from the human mitochondrial protein known as Humanin, which is composed of 24 amino acids. This peptide is notable for its neuroprotective properties and potential roles in cellular survival and metabolism. The modification at the 14th position, where glycine is substituted, enhances its stability and bioactivity. Humanin and its analogs, including (Gly14)-Humanin, have been studied for their effects on various cellular processes, including apoptosis, inflammation, and insulin signaling. The CAS number 330936-70-4 identifies this specific peptide in chemical databases, facilitating research and development in biomedical applications. Characteristically, (Gly14)-Humanin exhibits a relatively small molecular size, is soluble in aqueous solutions, and can interact with specific receptors to exert its biological effects. Its potential therapeutic implications are being explored in the context of neurodegenerative diseases, metabolic disorders, and age-related conditions, making it a subject of interest in both pharmacological and clinical research.

[Gly14]-Humanin

CAS: 330936-70-4

Humanin is an endogenous peptide which is encoded for by mitochondrial DNA. It has been described as a rescue factor due to it demonstrating the capabilities of abolishing neuronal cell death, therefore is can be used to as a potential treatment of Alzheimer’s disease. Another function of Humanin is it can inhibit mitochondira-dependent apoptosis through preventing the formation of apoptotic bodies and the release of Cytochrome C.
Humanin has been found to be related to aging related cardiovascular disease (ACVDs) due to evidence of Humanin serum levels as age increases. Furthermore Humanin increases the expression of antioxidant defense system proteins and impedes complexes I and III from their activity in the electron transport chain in myocardial cells and mitochondria, therefore decreasing oxidative stress damage caused by H2O2. Humanin further reduces reactive oxygen species production and protects cardiomyocytes and fibroblasts, from oxidative stress.
Overall Humanin has a variety of protective functions such as mitochondrial homeostasis and redox systems regulation, anti-aging, prevention of myocardial fibrosis, anti-inflammation, metabolism improvement and autophagy promotion. It has also been found to improve beta-cell survival and thus can be used as a diabetes treatment due to it improving insulin secretion and resistance.
This Humanin product has had the serine at position 14 on the amino acid chain replaced with a Glycine. This modification has been known to enhance the cytoprotective activity of Humanin by 1000 fold and proves to be highly anti-apoptotic. Therefore this product is of scientific interest for research laboratories. It is available as a 0.5mg vial.

Formula: C₁₁₈H₂₀₂N₃₄O₃₁S₂

Purity: Min. 95%

Molecular weight: 2,657.2 g/mol

Ref: 3D-PHN-4385-V

(Gly14)-Humanin (human) trifluoroacetate salt

CAS: 330936-70-4

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Formula: C₁₁₈H₂₀₂N₃₄O₃₁S₂

Purity: Min. 95%

Molecular weight: 2,657.21 g/mol

Ref: 3D-FG109548

(Gly¹⁴)-Humanin (human)

CAS: 330936-70-4

S14G-Humanin (HNG) is a more potent neuroprotective factor than native humanin. In middle-aged APPswe/PS1dE9 mice, the mutant peptide improved cognitive deficits and reduced amyloid pathology. S14G-Humanin inhibited Aβ 1-42 fibril formation, disaggregates preformed fibrils, and protects against Abeta-induced cytotoxicity in vitro.

Formula: C₁₁₈H₂₀₂N₃₄O₃₁S₂

Purity: > 95%

Color and Shape: White Powder

Molecular weight: 2657.25

Ref: 01-4038277