CAS 33125-97-2

Etomidate

Description:

Etomidate is a short-acting intravenous anesthetic agent primarily used for the induction of general anesthesia and sedation. It is characterized by its rapid onset and short duration of action, making it particularly useful in emergency settings and for procedures requiring quick recovery. Chemically, etomidate is classified as an imidazole derivative, with a structure that allows it to easily cross the blood-brain barrier. Its mechanism of action involves enhancing the activity of gamma-aminobutyric acid (GABA) at the GABA-A receptor, leading to increased inhibitory neurotransmission. Etomidate is known for its minimal cardiovascular and respiratory effects, which makes it a preferred choice for patients with compromised hemodynamics. However, it can cause adrenal suppression due to its effects on steroidogenesis, which is an important consideration in clinical use. The substance is typically administered intravenously and is available in a lipid emulsion formulation to improve solubility. Overall, etomidate is valued for its safety profile and effectiveness in inducing anesthesia.

Formula: C₁₄H₁₆N₂O₂

InChI: InChI=1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m1/s1

InChI key: InChIKey=NPUKDXXFDDZOKR-LLVKDONJSA-N

SMILES: [C@H](C)(N1C(C(OCC)=O)=CN=C1)C2=CC=CC=C2

Synonyms:

• (+)-Etomidate
• (R)-Ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate
• 1H-Imidazole-5-carboxylic acid, 1-(1-phenylethyl)-, ethyl ester, (R)-
• <span class="text-smallcaps">D</span>-Etomidate
• Amidate
• Amidate (pharmaceutical)
• D-Etomidate
• Etomidat
• Etomidato
• Hypnomidate
• Imidazole-5-carboxylic acid, 1-(α-methylbenzyl)-, ethyl ester, (R)-(+)-
• Lipuro
• Propiscin
• R 16659
• R-(+)-Etomidate
• Radenarcon

Etomidate

CAS: 33125-97-2

Formula: C₁₄H₁₆N₂O₂

Purity: >98.0%(GC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 244.29

Ref: 3B-E0897

Etomidate

CAS: 33125-97-2

Color and Shape: Neat

Ref: 61-FOR1264.00

Etomidate 0.1 mg/ml in Methanol

CAS: 33125-97-2

Color and Shape: Single Solution

Ref: 61-AMP1264.00-02

Etomidate 1.0 mg/ml in Methanol

CAS: 33125-97-2

Color and Shape: Single Solution

Ref: 61-AMP1264.00-01

ETOMIDATE CRS

CAS: 33125-97-2

ETOMIDATE CRS

Formula: C₁₄H₁₆N₂O₂

Molecular weight: 244.289

Ref: 41-E2503000

Etomidate

CAS: 33125-97-2

Compounds containing an unfused imidazole ring, whether or not hydrogenated, in the structure, nesoi

Formula: C₁₄H₁₆N₂O₂

Color and Shape: White Off-White Powder

Molecular weight: 244.29 g/mol

Ref: 45-1268750

Etomidate-d5

CAS: 33125-97-2

Formula: C₁₄H₁₁D₅N₂O₂

Color and Shape: Colorless Oil

Molecular weight: 249.32

Ref: 4Z-E-076016

Etomidate

CAS: 33125-97-2

Formula: C₁₄H₁₆N₂O₂

Molecular weight: 244.29

Ref: 4Z-E-076014

Etomidate

Controlled Product

CAS: 33125-97-2

Formula: C₁₄H₁₆N₂O₂

Color and Shape: Neat

Molecular weight: 244.29

Ref: 86-MM1264.00

Etomidate

CAS: 33125-97-2

Formula: C₁₄H₁₆N₂O₂

Purity: ≥ 98.0%

Color and Shape: White solid

Molecular weight: 244.29

Ref: 7W-GL9418

Etomidate-d5 (ester-d5)

CAS: 33125-97-2

Formula: C₁₄H₁₆N₂O₂

Molecular weight: 244.29

Ref: 4Z-E-076015

Etomidate-D5

Controlled Product

CAS: 33125-97-2

Applications A labelled isotope of Etomidate (E933300) which is used in neuroprotective products.
References Goetz, E., et al.: Anaesthesist, 23, 331 (1974), Chang, Z. L., et al.: Anal. Profiles Drug Subs., 12, 191 (1983),

Formula: C₁₄D₅H₁₁N₂O₂

Color and Shape: Neat

Molecular weight: 249.32

Ref: TR-E933302

Etomidate

Controlled Product

CAS: 33125-97-2

Applications Etomidate is a hypnotic. Neuroprotective & Neuroresearch Products
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Goetz, E., et al.: Anaesthesist, 23, 331 (1974), Chang, Z. L., et al.: Anal. Profiles Drug Subs., 12, 191 (1983),

Formula: C₁₄H₁₆N₂O₂

Color and Shape: Off-White

Molecular weight: 244.29

Ref: TR-E933300

Etomidate

Controlled Product

CAS: 33125-97-2

Etomidate is a potent, non-competitive, centrally acting α-adrenergic receptor agonist that has been used as a diagnostic agent and anesthetic. It is also used in the treatment of diabetic neuropathy. Etomidate binds to the α-adrenergic receptors on the presynaptic membrane and blocks the release of norepinephrine. This prevents nerve impulses from being transmitted to the muscle cells, leading to relaxation of muscles. Etomidate also inhibits locomotor activity by inhibiting postsynaptic neurons in the spinal cord that are responsive to acetylcholine. Etomidate is not active against polymorphonuclear leucocytes or water vapor. The risk group for etomidate includes patients who have had intubations, those with systolic pressures greater than 120 mmHg, and those with heart rates greater than 100 beats per minute. The mechanism of action for etomidate is thought to be through formation of stable complexes with nitrogen atoms.

Formula: C₁₄H₁₆N₂O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 244.29 g/mol

Ref: 3D-FE23198

(R)-Ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate

CAS: 33125-97-2

Formula: C₁₄H₁₆N₂O₂

Purity: 95.0%

Color and Shape: Solid, White powder

Molecular weight: 244.294

Ref: 10-F079091

Etomidate

CAS: 33125-97-2

Formula: C₁₄H₁₆N₂O₂

Molecular weight: 244.29

Ref: ST-EA-CP-E41000