CAS 33125-97-2
:Etomidate
Description:
Etomidate is a short-acting intravenous anesthetic agent primarily used for the induction of general anesthesia and sedation. It is characterized by its rapid onset and short duration of action, making it particularly useful in emergency settings and for procedures requiring quick recovery. Chemically, etomidate is classified as an imidazole derivative, with a structure that allows it to easily cross the blood-brain barrier. Its mechanism of action involves enhancing the activity of gamma-aminobutyric acid (GABA) at the GABA-A receptor, leading to increased inhibitory neurotransmission. Etomidate is known for its minimal cardiovascular and respiratory effects, which makes it a preferred choice for patients with compromised hemodynamics. However, it can cause adrenal suppression due to its effects on steroidogenesis, which is an important consideration in clinical use. The substance is typically administered intravenously and is available in a lipid emulsion formulation to improve solubility. Overall, etomidate is valued for its safety profile and effectiveness in inducing anesthesia.
Formula:C14H16N2O2
InChI:InChI=1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m1/s1
InChI key:InChIKey=NPUKDXXFDDZOKR-LLVKDONJSA-N
SMILES:[C@H](C)(N1C(C(OCC)=O)=CN=C1)C2=CC=CC=C2
Synonyms:- (+)-Etomidate
- (R)-Ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate
- 1H-Imidazole-5-carboxylic acid, 1-(1-phenylethyl)-, ethyl ester, (R)-
- <span class="text-smallcaps">D</span>-Etomidate
- Amidate
- Amidate (pharmaceutical)
- D-Etomidate
- Etomidat
- Etomidato
- Hypnomidate
- Imidazole-5-carboxylic acid, 1-(α-methylbenzyl)-, ethyl ester, (R)-(+)-
- Lipuro
- Propiscin
- R 16659
- R-(+)-Etomidate
- Radenarcon
- See more synonyms
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Etomidate
CAS:Formula:C14H16N2O2Purity:>98.0%(GC)Color and Shape:White to Almost white powder to crystalMolecular weight:244.29Etomidate
CAS:Compounds containing an unfused imidazole ring, whether or not hydrogenated, in the structure, nesoiFormula:C14H16N2O2Color and Shape:White Off-White PowderMolecular weight:244.12118Etomidate-D5
CAS:Controlled ProductApplications A labelled isotope of Etomidate (E933300) which is used in neuroprotective products.
References Goetz, E., et al.: Anaesthesist, 23, 331 (1974), Chang, Z. L., et al.: Anal. Profiles Drug Subs., 12, 191 (1983),Formula:C14D5H11N2O2Color and Shape:NeatMolecular weight:249.32Etomidate
CAS:Controlled ProductApplications Etomidate is a hypnotic. Neuroprotective & Neuroresearch Products
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Goetz, E., et al.: Anaesthesist, 23, 331 (1974), Chang, Z. L., et al.: Anal. Profiles Drug Subs., 12, 191 (1983),Formula:C14H16N2O2Color and Shape:NeatMolecular weight:244.29Etomidate
CAS:Controlled ProductEtomidate is a potent, non-competitive, centrally acting α-adrenergic receptor agonist that has been used as a diagnostic agent and anesthetic. It is also used in the treatment of diabetic neuropathy. Etomidate binds to the α-adrenergic receptors on the presynaptic membrane and blocks the release of norepinephrine. This prevents nerve impulses from being transmitted to the muscle cells, leading to relaxation of muscles. Etomidate also inhibits locomotor activity by inhibiting postsynaptic neurons in the spinal cord that are responsive to acetylcholine. Etomidate is not active against polymorphonuclear leucocytes or water vapor. The risk group for etomidate includes patients who have had intubations, those with systolic pressures greater than 120 mmHg, and those with heart rates greater than 100 beats per minute. The mechanism of action for etomidate is thought to be through formation of stable complexes with nitrogen atoms.Formula:C14H16N2O2Purity:Min. 95%Color and Shape:PowderMolecular weight:244.29 g/mol(R)-Ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate
CAS:Formula:C14H16N2O2Purity:95.0%Color and Shape:SolidMolecular weight:244.294
