CAS 331717-45-4: 3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate hydrate
CAS 331717-45-4: 3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate hydrate
Description:3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate hydrate, commonly referred to as CHAPS, is a zwitterionic detergent widely used in biochemistry and molecular biology. It features a hydrophilic sulfonate group and a hydrophobic cholamine tail, which allows it to solubilize membrane proteins while maintaining their functional integrity. CHAPS is known for its mild nature compared to other detergents, making it suitable for applications such as protein extraction, purification, and stabilization. It is particularly effective in maintaining protein structure and activity during electrophoresis and chromatography. The substance is typically supplied as a hydrate, indicating the presence of water molecules in its crystalline form, which can influence its solubility and stability. CHAPS is also characterized by its ability to form micelles, which can encapsulate hydrophobic molecules, enhancing their solubility in aqueous environments. Its zwitterionic nature minimizes non-specific interactions, making it a preferred choice in various biochemical assays and studies involving membrane proteins.
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