CAS 331741-94-7

Muraglitazar

Description:

Muraglitazar is a synthetic compound that belongs to the class of dual peroxisome proliferator-activated receptor (PPAR) agonists, specifically targeting PPAR-alpha and PPAR-gamma. It was primarily investigated for its potential use in the treatment of type 2 diabetes and related metabolic disorders due to its ability to improve insulin sensitivity and lipid metabolism. The compound exhibits anti-inflammatory properties and has been shown to influence glucose homeostasis. Muraglitazar's mechanism of action involves the modulation of gene expression related to glucose and lipid metabolism, which can lead to beneficial effects on blood sugar levels and lipid profiles. However, like many investigational drugs, it may have side effects, including weight gain and fluid retention, which are common concerns with PPAR-gamma agonists. Its development has been subject to scrutiny, and while it showed promise in preclinical and early clinical studies, further research is necessary to fully understand its efficacy and safety profile.

Formula: C₂₉H₂₈N₂O₇

InChI: InChI=1S/C29H28N2O7/c1-20-26(30-28(37-20)22-6-4-3-5-7-22)16-17-36-24-10-8-21(9-11-24)18-31(19-27(32)33)29(34)38-25-14-12-23(35-2)13-15-25/h3-15H,16-19H2,1-2H3,(H,32,33)

InChI key: InChIKey=IRLWJILLXJGJTD-UHFFFAOYSA-N

SMILES: C(COC1=CC=C(CN(C(OC2=CC=C(OC)C=C2)=O)CC(O)=O)C=C1)C=3N=C(OC3C)C4=CC=CC=C4

Synonyms:

• Bms-298585
• Glycine, N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]-
• Muraglitazar
• N-(4-Methoxyphenoxycarbonyl)-N-[4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]benzyl]glycine
• N-[(4-Methoxyphenoxy)carbonyl]-N-[[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine
• N-[(4-methoxyphenoxy)carbonyl]-N-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]benzyl}glycine
• Pargluva

Muraglitazar

CAS: 331741-94-7

Muraglitazar (BMS-298585) is a PPAR α/γ dual agonist for the treatment of type 2 diabetes and associated dyslipidemia.

Formula: C₂₉H₂₈N₂O₇

Purity: 99.17%

Color and Shape: Solid

Molecular weight: 516.54

Ref: TM-T21587

Muraglitazar

CAS: 331741-94-7

Muraglitazar

Purity: ≥98%

Molecular weight: 516.54g/mol

Ref: 54-BUP07240

Muraglitazar

CAS: 331741-94-7

Formula: C₂₉H₂₈N₂O₇

Molecular weight: 516.54

Ref: 7W-GP9902

Muraglitazar

Controlled Product

CAS: 331741-94-7

Applications It is a peroxisome proliferator-activated receptor (PPAR) α/γ dual agonist.
References Barlocco, D., et al.: Curr. Opin. Invest. Drugs, 6, 427 (2005), Devasthale, P.V., et al.: J. Med. Chem., 48, 2248 (2005), Kendall, D.M., et al.: Diabetes care, 29, 1016 (2006),

Formula: C₂₉H₂₈N₂O₇

Color and Shape: Neat

Molecular weight: 516.54

Ref: TR-M796500