CAS 331770-21-9

Aurora Kinase Inhibitor II

Description:

Aurora Kinase Inhibitor II, with the CAS number 331770-21-9, is a small molecule that functions as an inhibitor of Aurora kinases, a family of serine/threonine kinases that play a crucial role in cell division and mitosis. This compound is primarily studied for its potential therapeutic applications in cancer treatment, as it can disrupt the normal function of Aurora kinases, leading to impaired cell proliferation and increased apoptosis in cancer cells. The chemical structure of Aurora Kinase Inhibitor II typically features specific functional groups that contribute to its binding affinity and selectivity for the target kinases. It is often evaluated in preclinical studies for its efficacy and safety profile, and its mechanism of action involves competitive inhibition, which prevents the phosphorylation of key substrates necessary for mitotic progression. As with many kinase inhibitors, the development of resistance and off-target effects are important considerations in its therapeutic use. Overall, Aurora Kinase Inhibitor II represents a significant area of research in the field of oncology and targeted therapies.

Formula: C₂₃H₂₀N₄O₃

Synonyms:

• N-(4-((6,7-Dimethoxyquinazolin-4-yl)amino)phenyl)benzamide
• IUN-70219
• Aurora kinase inhibitor-2
• inhibit,Aurora-A,Aurora kinase inhibitor2,Aurora Kinase,ATP-competitive,Aurora kinase inhibitor 2,Aurora kinase inhibitor-2,Aurora-B,Inhibitor

N-[4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenyl]-benzamide

CAS: 331770-21-9

Formula: C₂₃H₂₀N₄O₃

Purity: 90%

Color and Shape: Solid

Molecular weight: 400.4299

Ref: IN-DA01EPC8

Aurora kinase inhibitor-2

CAS: 331770-21-9

Aurora kinase inhibitor-2

Purity: ≥98%

Molecular weight: 400.43g/mol

Ref: 54-BUP08242

Aurora kinase inhibitor-2

CAS: 331770-21-9

Aurora kinase inhibitor-2 (IUN-70219) is a cell-permeable anilinoquinazoline that inhibit the activity of Aurora A (IC50 = 0.39 M).

Formula: C₂₃H₂₀N₄O₃

Purity: 98.66%

Color and Shape: Solid

Molecular weight: 400.43

Ref: TM-T9040