CAS 331771-20-1

N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide

Description:

N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide, with CAS number 331771-20-1, is a synthetic organic compound characterized by its complex molecular structure, which includes a quinazoline core, a methoxy group, and a morpholine moiety. This compound typically exhibits properties such as moderate solubility in organic solvents and potential bioactivity, making it of interest in medicinal chemistry, particularly in the development of pharmaceuticals. Its structure suggests that it may interact with specific biological targets, potentially influencing pathways related to cell signaling or proliferation. The presence of the morpholine ring may enhance its pharmacokinetic properties, such as absorption and distribution. Additionally, the compound's ability to form hydrogen bonds and engage in π-π stacking interactions could contribute to its binding affinity with target proteins. Overall, this compound represents a class of small molecules that may have therapeutic applications, although further studies would be necessary to fully elucidate its biological effects and mechanisms of action.

Formula: C₂₉H₃₁N₅O₄

InChI: InChI=1S/C29H31N5O4/c1-36-26-18-24-25(19-27(26)38-15-5-12-34-13-16-37-17-14-34)30-20-31-28(24)32-22-8-10-23(11-9-22)33-29(35)21-6-3-2-4-7-21/h2-4,6-11,18-20H,5,12-17H2,1H3,(H,33,35)(H,30,31,32)

InChI key: InChIKey=OGNYUTNQZVRGMN-UHFFFAOYSA-N

SMILES: N(C=1C2=C(C=C(OCCCN3CCOCC3)C(OC)=C2)N=CN1)C4=CC=C(NC(=O)C5=CC=CC=C5)C=C4

Synonyms:

• Benzamide, N-[4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]-
• N-[4-({6-Methoxy-7-[3-(morpholin-4-yl)propoxy]quinazolin-4-yl}amino)phenyl]benzamide
• N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide
• Tcmdc-125873
• Zm 447439
• Zm447439

ZM 447439

CAS: 331771-20-1

Formula: C₂₉H₃₁N₅O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 513.5875

Ref: IN-DA00C0VP

ZM-447439

CAS: 331771-20-1

ZM-447439

Purity: ≥98%

Molecular weight: 513.59g/mol

Ref: 54-BUP14426

ZM-447439

CAS: 331771-20-1

ZM 447439 selectively inhibits Aurora A/B (IC50: 110/130 nM); 8x less effective on MEK1, Src, Lck; minimal impact on CDK1/2/4, Plk1, Chk1.

Formula: C₂₉H₃₁N₅O₄

Purity: 99.11% - 99.59%

Color and Shape: Pale Yellow Solid

Molecular weight: 513.59

Ref: TM-T6077

ZM 447439

Controlled Product

CAS: 331771-20-1

Applications It is a potent and selective inhibitor of Aurora B kinase. Cells treated with ZM-447439 progress through interphase, enter mitosis and assemble bipolar spindles but chromosome alignment, segregation and cytokinesis all fail. It induces apoptosos in Hep2 cancer cells and in acute myeloid leukemia cell lines but its propensity to induce polyploidy does not inevitably result in apoptosis.
References Ditchfield, C., et al.: J. Cell Biol., 161, 267 (2003), Long, Z.J., et al.: J. Cell Cycle, 7, 1473 (2008), Walsby, E., et al.: Haematologica, 93, 662 (2008),

Formula: C₂₉H₃₁N₅O₄

Color and Shape: Neat

Molecular weight: 513.59

Ref: TR-Z487000

N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide

CAS: 331771-20-1

Formula: C₂₉H₃₁N₅O₄

Purity: 98%

Color and Shape: Liquid

Molecular weight: 513.598

Ref: 10-F092554