CAS 33178-86-8

Alinidine

Description:

Alinidine is a chemical compound classified as an antihypertensive agent, primarily used for the treatment of high blood pressure. It functions as a selective alpha-2 adrenergic agonist, which means it works by stimulating alpha-2 adrenergic receptors in the central nervous system, leading to a decrease in sympathetic outflow and a subsequent reduction in blood pressure. Alinidine is known for its ability to lower heart rate and reduce peripheral vascular resistance. The compound has a relatively low solubility in water, which can affect its bioavailability and absorption in the body. Its pharmacokinetics involve hepatic metabolism, and it is typically administered orally. As with many medications, potential side effects may include sedation, dry mouth, and dizziness, among others. Due to its specific mechanism of action and effects on the cardiovascular system, Alinidine is used in clinical settings under medical supervision, and its use may be limited by the availability of newer antihypertensive agents.

Formula: C₁₂H₁₃Cl₂N₃

InChI: InChI=1/C12H13Cl2N3/c1-2-8-17(12-15-6-7-16-12)11-9(13)4-3-5-10(11)14/h2-5H,1,6-8H2,(H,15,16)

InChI key: InChIKey=OXTYVEUAQHPPMV-UHFFFAOYSA-N

SMILES: N(CC=C)(C1=C(Cl)C=CC=C1Cl)C=2NCCN2

Synonyms:

• 1H-Imidazol-2-amine, N-(2,6-dichlorophenyl)-4,5-dihydro-N-2-propenyl-
• 1H-imidazol-2-amine, N-(2,6-dichlorophenyl)-4,5-dihydro-N-2-propen-1-yl-
• 2-Imidazoline, 2-(N-allyl-2,6-dichloroanilino)-
• 2-[N-Allyl-N-(2,6-dichlorophenyl)amino]-2-imidazoline
• Alinidin
• Alinidina
• Alinidine [BAN:INN]
• Alinidinum
• N-(2,6-Dichlorophenyl)-4,5-dihydro-N-2-propen-1-yl-1H-imidazol-2-amine
• N-(2,6-dichlorophenyl)-N-prop-2-en-1-yl-4,5-dihydro-1H-imidazol-2-amine
• St 567
• Alinidine

Alinidine

CAS: 33178-86-8

Alinidine is an HCN channel blocker with antiarrhythmic effects and can be used for the study of angina pectoris.

Formula: C₁₂H₁₃Cl₂N₃

Purity: 98.91% - >99.99%

Color and Shape: Solid

Molecular weight: 270.16

Ref: TM-T83980

Alinidine

CAS: 33178-86-8

Alinidine

Purity: ≥98%

Molecular weight: 270.16g/mol

Ref: 54-BUP01482

Alinidine

Controlled Product

CAS: 33178-86-8

Applications Alinidine has a blocking effect on calcium and potassium channels. It also causes elongation of re-polarisation after an action potential.
References Current Opinion in Pharmacology, 7, 208–213 (2007);

Formula: C₁₂H₁₃Cl₂N₃

Color and Shape: Neat

Molecular weight: 270.158

Ref: TR-A535975