CAS 332012-40-5

Telatinib

Description:

Telatinib is a small molecule inhibitor primarily known for its role in targeting specific tyrosine kinases involved in cancer cell proliferation and survival. It is classified as an anti-cancer agent, particularly focusing on inhibiting the activity of vascular endothelial growth factor receptors (VEGFR) and platelet-derived growth factor receptors (PDGFR). This dual inhibition is significant in the context of tumor angiogenesis and growth. Telatinib is typically administered orally and has been investigated in various clinical trials for its efficacy in treating solid tumors. The compound's chemical structure includes functional groups that contribute to its pharmacological activity, and it exhibits moderate solubility in organic solvents. Its mechanism of action involves blocking the signaling pathways that promote tumor growth and metastasis, making it a candidate for combination therapies in oncology. As with many targeted therapies, the side effect profile may include hypertension and gastrointestinal disturbances, necessitating careful monitoring during treatment. Overall, Telatinib represents a strategic approach in the development of targeted cancer therapies.

Formula: C₂₀H₁₆ClN₅O₃

InChI: InChI=1S/C20H16ClN5O3/c1-22-19(27)16-10-12(6-8-23-16)11-29-20-17-15(7-9-28-17)18(25-26-20)24-14-4-2-13(21)3-5-14/h2-10H,11H2,1H3,(H,22,27)(H,24,25)

InChI key: InChIKey=QFCXANHHBCGMAS-UHFFFAOYSA-N

SMILES: N(C1=C2C(=C(OCC=3C=C(C(NC)=O)N=CC3)N=N1)OC=C2)C4=CC=C(Cl)C=C4

Synonyms:

• 2-Pyridinecarboxamide,4-[[[4-[(4-chlorophenyl)amino]furo[2,3-d]pyridazin-7-yl]oxy]methyl]-N-methyl-
• 4-[[[4-[(4-Chlorophenyl)amino]furo[2,3-d]pyridazin-7-yl]oxy]methyl]-N-methyl-2-pyridinecarboxamide
• Bay 57-9352
• Bay57-9352
• Telatinib
• 4-(((4-((4-Chlorophenyl)amino)furo[2,3-d]pyridazin-7-yl)oxy)methyl)-N-methylpicolinamide
• 4-[[[4-[(4-Chlorophenyl)amino]furo[2,3-d]pyridazin-7-yl]oxy]methyl]-N-methyl-2-pyridinecarboxamide Telatinib(BAY57-9352)
• Unii-18p7197Q7j
• Telatinib USP/EP/BP
• CS-361
• 4-((4-(4-chlorophenylamino)furo[2,3-d]pyridazin-7-yloxy)methyl)-N-methylpicolinamide
• Telatinib(BAY 57-9352)
• Telatnib
• 4-[[4-(4-Chloroanilino)furo[2,3-d]pyridazin-7-yl]oxymethyl]-N-methyl-pyridine-2-carboxamide

Telatinib

CAS: 332012-40-5

Formula: C₂₀H₁₆ClN₅O₃

Purity: 98%

Molecular weight: 409.8257

Ref: IN-DA00C6JY

Telatinib

CAS: 332012-40-5

Telatinib

Purity: ≥95%

Molecular weight: 409.83g/mol

Ref: 54-BUP11543

Telatinib

CAS: 332012-40-5

Telatinib (Bay 57-9352) inhibits VEGFR2/3, c-Kit, PDGFRα with IC50s: 6 nM, 4 nM, 1 nM, 15 nM.

Formula: C₂₀H₁₆ClN₅O₃

Purity: 97.61% - 99.81%

Color and Shape: Solid

Molecular weight: 409.83

Ref: TM-T6166

Telatinib

Controlled Product

CAS: 332012-40-5

Applications Telatinib small-molecule inhibitor of vascular endothelial growth factor receptors 2 and 3 (VEGFR-2/-3) and platelet-derived growth factor receptor β tyrosine kinases. Telatinib is used therapeutically in patients with advanced solid tumors.
References Strumberg, D. et al.: Br. J. Cancer, 99, 1579 (2008); Steeghs, N. et al.: Invest. New Drugs, 29, 137 (2011); Mross, K. et al.: Vasc. Cell, 3, 16 (2011);

Formula: C₂₀H₁₆ClN₅O₃

Color and Shape: Neat

Molecular weight: 409.826

Ref: TR-T015700

Telatinib

CAS: 332012-40-5

Telatinib is a tyrosine kinase inhibitor that belongs to the group of cancer drugs. It is an orally available, small-molecule drug that inhibits the activity of receptor tyrosine kinases (RTKs). Telatinib has been shown to inhibit angiogenesis and to reduce tumour size and volume in solid tumours. In addition, telatinib inhibits the production of cytokines and other pro-inflammatory factors such as interleukin-6, IL-8, vascular endothelial growth factor, and glycoprotein 130. Telatinib also binds to ABCG2 transporter proteins and prevents them from absorbing drugs in the gastrointestinal tract. Telatinib has been tested in humans for indications such as renal cell carcinoma, cervical cancer, skin cancer, and other solid tumours.

Formula: C₂₀H₁₆ClN₅O₃

Purity: Min. 95%

Molecular weight: 409.83 g/mol

Ref: 3D-HNA01240