CAS 332012-40-5: Telatinib

Description: Telatinib is a small molecule inhibitor primarily known for its role in targeting specific tyrosine kinases involved in cancer cell proliferation and survival. It is classified as an anti-cancer agent, particularly focusing on inhibiting the activity of vascular endothelial growth factor receptors (VEGFR) and platelet-derived growth factor receptors (PDGFR). This dual inhibition is significant in the context of tumor angiogenesis and growth. Telatinib is typically administered orally and has been investigated in various clinical trials for its efficacy in treating solid tumors. The compound's chemical structure includes functional groups that contribute to its pharmacological activity, and it exhibits moderate solubility in organic solvents. Its mechanism of action involves blocking the signaling pathways that promote tumor growth and metastasis, making it a candidate for combination therapies in oncology. As with many targeted therapies, the side effect profile may include hypertension and gastrointestinal disturbances, necessitating careful monitoring during treatment. Overall, Telatinib represents a strategic approach in the development of targeted cancer therapies.

Formula: C₂₀H₁₆ClN₅O₃

InChI: InChI=1S/C20H16ClN5O3/c1-22-19(27)16-10-12(6-8-23-16)11-29-20-17-15(7-9-28-17)18(25-26-20)24-14-4-2-13(21)3-5-14/h2-10H,11H2,1H3,(H,22,27)(H,24,25)

InChI key: InChIKey=QFCXANHHBCGMAS-UHFFFAOYSA-N

SMILES: O=C(NC)C1=NC=CC(=C1)COC2=NN=C(NC3=CC=C(Cl)C=C3)C=4C=COC24

Synonyms:

• 2-Pyridinecarboxamide,4-[[[4-[(4-chlorophenyl)amino]furo[2,3-d]pyridazin-7-yl]oxy]methyl]-N-methyl-
• 4-[[[4-[(4-Chlorophenyl)amino]furo[2,3-d]pyridazin-7-yl]oxy]methyl]-N-methyl-2-pyridinecarboxamide
• Bay 57-9352
• Bay57-9352
• Telatinib
• 4-(((4-((4-Chlorophenyl)amino)furo[2,3-d]pyridazin-7-yl)oxy)methyl)-N-methylpicolinamide

Telatinib

CAS: 332012-40-5

• Formula: C₂₀H₁₆ClN₅O₃
• Purity: 98%
• Molecular weight: 409.8257

Telatinib

CAS: 332012-40-5

• Purity: 98.95%
• Molecular weight: 409.83g/mol

Telatinib

CAS: 332012-40-5

Telatinib (Bay 57-9352) inhibits VEGFR2/3, c-Kit, PDGFRα with IC50s: 6 nM, 4 nM, 1 nM, …

• Formula: C₂₀H₁₆ClN₅O₃
• Purity: 97.61% - 99.81%
• Color and Shape: Solid
• Molecular weight: 409.83

Telatinib

CAS: 332012-40-5

Applications Telatinib small-molecule inhibitor of vascular endothelial growth factor receptors 2 and 3 (VEGFR-2/-3) and …

• Formula: C₂₀H₁₆ClN₅O₃
• Color and Shape: Neat
• Molecular weight: 409.826

Telatinib

CAS: 332012-40-5

Please enquire for more information about Telatinib including the price, delivery time and more detailed …

• Formula: C₂₀H₁₆ClN₅O₃
• Purity: Min. 95%
• Molecular weight: 409.83 g/mol