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CAS 33286-22-5

:

Diltiazem HCl

Description:
Diltiazem hydrochloride is a calcium channel blocker primarily used in the treatment of hypertension and angina pectoris. It functions by inhibiting the influx of calcium ions into cardiac and smooth muscle cells, leading to vasodilation and reduced heart rate. This compound is typically presented as a white to off-white crystalline powder, which is soluble in water and alcohol, making it suitable for various pharmaceutical formulations. Diltiazem HCl has a molecular formula that reflects its complex structure, which includes a benzothiazepine core. Its pharmacological effects are attributed to its ability to relax vascular smooth muscle and decrease myocardial oxygen demand. The substance is often administered orally or intravenously, depending on the clinical scenario. Side effects may include dizziness, headache, and gastrointestinal disturbances, among others. As with any medication, it is essential to consider contraindications and potential interactions with other drugs. Overall, Diltiazem HCl plays a significant role in cardiovascular therapy, providing relief for patients with specific heart-related conditions.
Formula:C22H27ClN2O4S
InChI:InChI=1/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3;/h5-12,20-21H,13-14H2,1-4H3;1H/t20-,21+;/m1./s1
InChI key:InChIKey=HDRXZJPWHTXQRI-BHDTVMLSSA-N
SMILES:O(C(C)=O)[C@@H]1[C@@](SC=2C(N(CCN(C)C)C1=O)=CC=CC2)(C3=CC=C(OC)C=C3)[H].Cl
Synonyms:
  • (2S,3S)-(+)-cis-Diltiazem hydrochloride
  • (2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate
  • (2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate hydrochloride (1:1)
  • (S,S)-Diltiazem hydrochloride
  • 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-, hydrochloride (1:1), (2S,3S)-
  • 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-, monohydrochloride, (2S,3S)-
  • 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-, monohydrochloride, (2S-cis)-
  • Adizem
  • Altiazem
  • Anginyl
  • See more synonyms
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