CAS 33369-31-2

Zomepirac

Description:

Zomepirac is a non-steroidal anti-inflammatory drug (NSAID) that was primarily used for its analgesic and anti-inflammatory properties. It belongs to the class of compounds known as arylacetic acids. Zomepirac is characterized by its ability to inhibit cyclooxygenase (COX) enzymes, which play a crucial role in the synthesis of prostaglandins, mediators of inflammation and pain. The chemical structure of zomepirac includes a carboxylic acid functional group, contributing to its acidic nature. It is typically administered orally and has been utilized in the management of pain and inflammation associated with various conditions. However, zomepirac has been associated with adverse effects, including gastrointestinal complications and hypersensitivity reactions, which led to its withdrawal from the market in many regions. Its pharmacokinetics involve absorption, distribution, metabolism, and excretion processes that determine its therapeutic efficacy and safety profile. Overall, zomepirac exemplifies the complexities of drug development and the importance of balancing therapeutic benefits with potential risks.

Formula: C₁₅H₁₄ClNO₃

InChI: InChI=1S/C15H14ClNO3/c1-9-7-12(8-13(18)19)17(2)14(9)15(20)10-3-5-11(16)6-4-10/h3-7H,8H2,1-2H3,(H,18,19)

InChI key: InChIKey=ZXVNMYWKKDOREA-UHFFFAOYSA-N

SMILES: C(=O)(C=1N(C)C(CC(O)=O)=CC1C)C2=CC=C(Cl)C=C2

Synonyms:

• 1,4-Dimethyl-5-p-chlorobenzoylpyrrole-2-acetic acid
• 1H-pyrrole-2-acetic acid, 5-(4-chlorobenzoyl)-1,4-dimethyl-
• 5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrole-2-acetic acid
• 5-(4-Chlorobenzoyl)-1,4-dimethylpyrrole-2-acetic acid
• Pyrrole-2-acetic acid, 5-(p-chlorobenzoyl)-1,4-dimethyl-
• Zomiperac
• [5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-yl]acetic acid
• {5-[(4-chlorophenyl)carbonyl]-1,4-dimethyl-1H-pyrrol-2-yl}acetic acid
• Zomepirac

Zomepirac free acid

CAS: 33369-31-2

Zomepirac is a prostaglandin synthetase inhibitor. Zomepirac is an orally effective nonsteroidal anti-inflammatory drug (NSAID) that has antipyretic actions.

Formula: C₁₅H₁₄ClNO₃

Color and Shape: Solid

Molecular weight: 291.73

Ref: TM-T69424

Zomepirac Sodium Salt Hydrate

Controlled Product

CAS: 33369-31-2

Stability Hygroscopic
Applications Zomepirac is an analgesic, anti-inflammatory drug.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sofia, R., et al.: Pharmacol. Res. Commun., 11, 179 (1979), Grindel, J.M., et al.: Drug Metab. Dispos., 8, 343 (1980), Steele, C.E., et al.: Curr. Med. Res. Opin., 8, 382 (1983),

Formula: C₁₅H₁₃ClNNaO₃•xH₂O

Color and Shape: Neat

Molecular weight: 313.71 + x(18.02)

Ref: TR-Z675005