CAS 333749-57-8

α,α'-Bis[(2-Methoxyphenoxy)Methyl]-1,4-piperazinediethanol

Description:

α,α'-Bis[(2-Methoxyphenoxy)Methyl]-1,4-piperazinediethanol, identified by its CAS number 333749-57-8, is a synthetic organic compound characterized by its complex molecular structure, which includes a piperazine core and two methoxyphenoxy methyl groups. This compound typically exhibits properties such as solubility in organic solvents, which is common for many piperazine derivatives, and may demonstrate moderate to high polarity due to the presence of hydroxyl and ether functional groups. Its structure suggests potential applications in medicinal chemistry, particularly in the development of pharmaceuticals, as piperazine derivatives are often explored for their biological activity. The presence of methoxy groups may enhance lipophilicity, potentially influencing the compound's pharmacokinetics and bioavailability. Additionally, the compound's ability to form hydrogen bonds due to the hydroxyl groups may contribute to its interactions with biological targets. Overall, α,α'-Bis[(2-Methoxyphenoxy)Methyl]-1,4-piperazinediethanol represents a class of compounds that could be of interest in drug design and development.

Formula: C₂₄H₃₄N₂O₆

Synonyms:

• 3,3''-(Piperazine-1,4-diyl)bis(1-(2-methoxyphenoxy)propan-ol)
• "a,a-Bis[(2-Methoxyphenoxy)methyl]-1,4-piperazinediethanol"
• Bis[(2-Methoxyphenoxy)methyl]-1,4-p
• α,α'-Bis[(2-Methoxyphenoxy)methyl]-1,4-piperazinediethanol
• Ranolazine Dimer Impurity
• 1,4-Piperazinediethanol, α1,α4-bis[(2-methoxyphenoxy)methyl]-
• α,α''-Bis[(2-Methoxyphenoxy)methyl]-1,4-piperazinediethano
• α,α'-Bis[(2-Methoxyphenoxy)Methyl]-1,4-piperazinediethanol

Ranolazine Alcohol Dimer (3,3'-(piperazine-1,4-diyl)bis(1-(2-methoxyphenoxy)propan-2-ol))

CAS: 333749-57-8

Compounds containing a pyrimidine ring, whether or not hydrogenated, or piperazine ring in the structure, nesoi

Formula: C₂₄H₃₄O₆N₂

Color and Shape: White Powder

Molecular weight: 446.24169

Ref: 45-1A13100

Ranolazine Impurity 19

CAS: 333749-57-8

Formula: C₂₄H₃₄N₂O₆

Color and Shape: White To Off-White Solid

Molecular weight: 446.54

Ref: 4Z-R-178

Ranolazine Dimer Impurity

CAS: 333749-57-8

Formula: C₂₄H₃₄N₂O₆

Molecular weight: 446.54

Ref: ST-EA-CP-R9005

a,a'-Bis[(2-Methoxyphenoxy)methyl]-1,4-piperazinediethanol

Controlled Product

CAS: 333749-57-8

Applications α,α'-Bis[(2-methoxyphenoxy)methyl]-1,4-piperazinediethanol is a metabolite of Ranolazine (R122500), an anti-ischemic agent which modulates myocardial metabolism. α,α'-Bis[(2-methoxyphenoxy)methyl]-1,4-piperazinediethanol is also known to exhibit anti-anginal activities.
References Aalla, S., et al.: Org. Process. Rsch. Develop., 16, 748 (2012); Chaitman, B.R., et al.: J. Am. Coll. Cardial., 43, 1375 (2004); McCormack, J.G., et al.: Gen. Pharmacol., 30, 639 (1998); Schofield, J.A.H., et al.: Expert Opin. Invest. Drugs, 11, 117 (2002);

Formula: C₂₄H₃₄N₂O₆

Color and Shape: White To Off-White

Molecular weight: 446.54

Ref: TR-B489850

α,α'-Bis[(2-methoxyphenoxy)methyl]-1,4-piperazinediethanol

CAS: 333749-57-8

α,α'-Bis[(2-methoxyphenoxy)methyl]-1,4-piperazinediethanol is an impurity in the drug ranolazine. It is a dimer of the active compound α,α'-bis[2-(methoxy)phenoxy]methyl-1,4-piperazine. This impurity has been shown to have antiarrhythmic properties.

Formula: C₂₄H₃₄N₂O₆

Purity: Min. 95%

Molecular weight: 446.5 g/mol

Ref: 3D-INA74957