CAS 334476-46-9

Vestipitant

Description:

Vestipitant, with the CAS number 334476-46-9, is a chemical compound that functions primarily as a neurokinin-1 (NK1) receptor antagonist. It is designed to inhibit the action of substance P, a neuropeptide involved in the transmission of pain and the regulation of various physiological processes, including mood and anxiety. Vestipitant has been investigated for its potential therapeutic applications in treating conditions such as anxiety disorders, depression, and nausea associated with chemotherapy. The compound is characterized by its ability to cross the blood-brain barrier, which is crucial for its effectiveness in central nervous system-related conditions. Additionally, it exhibits a favorable pharmacokinetic profile, including good oral bioavailability and a manageable half-life, making it suitable for clinical use. As with many pharmacological agents, the safety and efficacy of Vestipitant are subject to ongoing research and clinical trials to better understand its potential benefits and side effects in various patient populations.

Formula: C₂₃H₂₄F₇N₃O

InChI: InChI=1S/C23H24F7N3O/c1-13-8-18(24)4-5-19(13)20-12-31-6-7-33(20)21(34)32(3)14(2)15-9-16(22(25,26)27)11-17(10-15)23(28,29)30/h4-5,8-11,14,20,31H,6-7,12H2,1-3H3/t14-,20-/m1/s1

InChI key: InChIKey=SBBYBXSFWOLDDG-JLTOFOAXSA-N

SMILES: C(N([C@H](C)C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)C)(=O)N2[C@H](CNCC2)C3=C(C)C=C(F)C=C3

Synonyms:

• (2S)-N-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methyl-1-piperazinecarboxamide
• Vestipitant
• 1-Piperazinecarboxamide, N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methyl-, (2S)-

Vestipitant

CAS: 334476-46-9

Vestipitant (GW597599): a potent NK1 antagonist, may treat anxiety, depression, nausea, tinnitus, insomnia.

Formula: C₂₃H₂₄F₇N₃O

Color and Shape: Solid

Molecular weight: 491.45

Ref: TM-T69420