CAS 3346-23-4

2,6-diamino-5-nitropyrimidin-4(1H)-one

Description:

2,6-Diamino-5-nitropyrimidin-4(1H)-one, with the CAS number 3346-23-4, is a heterocyclic organic compound featuring a pyrimidine ring substituted with amino and nitro groups. This compound is characterized by its two amino groups located at the 2 and 6 positions and a nitro group at the 5 position of the pyrimidine ring, along with a keto group at the 4 position. It typically appears as a crystalline solid and is soluble in polar solvents. The presence of both amino and nitro groups contributes to its potential as a building block in pharmaceuticals and agrochemicals, particularly in the synthesis of various biologically active compounds. The compound may exhibit interesting chemical reactivity due to the electron-withdrawing nature of the nitro group and the nucleophilic properties of the amino groups. Its structural features suggest potential applications in medicinal chemistry, particularly in the development of antimicrobial or antitumor agents. As with many nitrogen-containing compounds, it may also be subject to specific regulatory considerations regarding its handling and use.

Formula: C₄H₅N₅O₃

InChI: InChI=1/C4H5N5O3/c5-2-1(9(11)12)3(10)8-4(6)7-2/h(H5,5,6,7,8,10)

SMILES: c1(c(N)[nH]c(=N)nc1O)N(=O)=O

Synonyms:

• 2,6-Diamino-5-nitropyrimidin-4(3H)-one
• 4(3H)-pyrimidinone, 2,6-diamino-5-nitro-

2,4-Diamino-6-hydroxy-5-nitropyrimidine

CAS: 3346-23-4

Formula: C₄H₅N₅O₃

Purity: 97%

Color and Shape: Solid

Molecular weight: 171.1142

Ref: IN-DA00CAQI

2,6-Diamino-5-Nitro-4(3H)-Pyrimidinone

CAS: 3346-23-4

Formula: C₄H₅N₅O₃

Molecular weight: 171.12

Ref: 4Z-P-212042

2,4-Diamino-6-hydroxy-5-nitropyrimidine

CAS: 3346-23-4

2,4-Diamino-6-hydroxy-5-nitropyrimidine is an anticancer agent that has been shown to be effective against both bone and colorectal cancers. It inhibits the growth of cancer cells by inducing caspase-independent cell death, which occurs in a pd-l1 dependent manner. This agent also has minimal toxicity in vitro, as it induces cell lysis at high concentrations. 2,4-Diamino-6-hydroxy-5-nitropyrimidine is not active against normal cells.
2,4-Diamino-6-hydroxy-5-nitropyrimidine induces mitochondrial membrane depolarization and mitochondrial membrane potential loss in a dose dependent manner. These effects are likely responsible for the induction of caspase independent cell death seen with this drug.

Formula: C₄H₅N₅O₃

Purity: Min. 95%

Color and Shape: Yellow Powder

Molecular weight: 171.11 g/mol

Ref: 3D-FD21462

2,4-DIAMINO-6-HYDROXY-5-NITROPYRIMIDINE

CAS: 3346-23-4

Formula: C₄H₅N₅O₃

Purity: 95%

Molecular weight: 171.116

Ref: 10-F513603