CAS 3352-69-0
:Deacetylvinblastine
Description:
Deacetylvinblastine, with the CAS number 3352-69-0, is a naturally occurring alkaloid derived from the periwinkle plant, Catharanthus roseus. It is a derivative of vinblastine, which is a well-known chemotherapeutic agent used in cancer treatment. Deacetylvinblastine exhibits similar pharmacological properties, primarily acting as an antineoplastic agent by inhibiting microtubule formation, thereby disrupting mitosis in cancer cells. This compound is characterized by its complex structure, which includes a tetracyclic indole alkaloid framework. It is typically found in a crystalline form and is soluble in organic solvents but has limited solubility in water. The compound's biological activity is attributed to its ability to bind to tubulin, preventing the polymerization necessary for microtubule assembly. As a result, it has garnered interest in research for its potential therapeutic applications in oncology. However, like many alkaloids, it may also exhibit toxicity, necessitating careful handling and dosage considerations in clinical settings.
Formula:C44H56N4O8
InChI:InChI=1S/C44H56N4O8/c1-7-40(52)22-26-23-43(38(50)55-5,34-28(14-18-47(24-26)25-40)27-12-9-10-13-31(27)45-34)30-20-29-32(21-33(30)54-4)46(3)36-42(29)16-19-48-17-11-15-41(8-2,35(42)48)37(49)44(36,53)39(51)56-6/h9-13,15,20-21,26,35-37,45,49,52-53H,7-8,14,16-19,22-25H2,1-6H3/t26-,35-,36+,37+,40-,41+,42+,43-,44-/m0/s1
InChI key:InChIKey=NDMPLJNOPCLANR-XQLDGQACSA-N
SMILES:C(C)[C@@]12[C@]3([C@]4(C=5C(N(C)[C@]4([C@](C(OC)=O)(O)[C@@H]1O)[H])=CC(OC)=C(C5)[C@]6(C(OC)=O)C7=C(C=8C(N7)=CC=CC8)CC[N@@]9C[C@](C6)(C[C@](CC)(O)C9)[H])CCN3CC=C2)[H]
Synonyms:- 1H-Indolizino[8,1-cd]carbazole, vincaleukoblastine deriv.
- O4-Deacetylvincaleukoblastine
- Vincaleukoblastine, deacetyl-
- Vincaleukoblastine, O4-deacetyl-
- 2H-3,7-Methanoazacycloundecino[5,4-b]indole, vincaleukoblastine deriv.
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Found 3 products.
DESACETYLVINBLASTINE CRS
CAS:<p>DESACETYLVINBLASTINE CRS</p>Formula:C44H56N4O8Molecular weight:768.9374Desacetylvinblastine
CAS:Controlled Product<p>Desacetylvinblastine is a natural product that has been shown to have potent antitumor activity and antiangiogenic properties. It has been used as a diagnostic agent in vitro assays for the detection of platinum-resistant ovarian cancer. Desacetylvinblastine also binds to P-glycoprotein, an efflux pump protein which is expressed on cancer cells and is responsible for removing chemotherapeutic drugs from the cell. This compound has been shown to inhibit angiogenesis and tumor growth in mouse models.</p>Formula:C44H56N4O8Purity:Min. 95%Molecular weight:768.9 g/mol
