CAS 33570-04-6

Bilobalide

Description:

Bilobalide is a naturally occurring sesquiterpene compound primarily found in the leaves of the Ginkgo biloba tree. It is recognized for its potential neuroprotective properties and is often studied for its effects on cognitive function and memory enhancement. Bilobalide is characterized by its unique chemical structure, which includes a bicyclic framework, contributing to its biological activity. The compound is known to exhibit antioxidant properties, helping to mitigate oxidative stress in neural tissues. Additionally, bilobalide has been investigated for its role in modulating neurotransmitter systems, particularly in relation to serotonin and dopamine pathways. Its pharmacological profile suggests potential therapeutic applications in conditions such as Alzheimer's disease and other neurodegenerative disorders. However, while bilobalide shows promise, further research is necessary to fully understand its mechanisms of action and efficacy in clinical settings. As a compound, it is generally considered safe, but like any substance, it should be used with caution and under appropriate guidance, especially in supplement form.

Formula: C₁₅H₁₈O₈

InChI: InChI=1S/C15H18O8/c1-12(2,3)14(20)4-6-13(5-7(16)21-6)10(19)23-11-15(13,14)8(17)9(18)22-11/h6,8,11,17,20H,4-5H2,1-3H3/t6-,8-,11-,13-,14+,15+/m0/s1

InChI key: InChIKey=MOLPUWBMSBJXER-YDGSQGCISA-N

SMILES: C(C)(C)(C)[C@@]1(O)[C@@]23[C@@]4([C@](C1)(OC(=O)C4)[H])C(=O)O[C@@]2(OC(=O)[C@@H]3O)[H]

Synonyms:

• (3aS,5aR,8R,8aS,9R,10aS)-9-(1,1-Dimethylethyl)-10,10a-dihydro-8,9-dihydroxy-4H,5aH,9H-furo[2,3-b]furo[3′,2′:2,3]cyclopenta[1,2-c]furan-2,4,7(3H,8H)-trione
• (3aS,5aS,9R,10aS)-9-tert-butyl-8,9-dihydroxydihydro-9H-furo[2,3-b]furo[3',2':2,3]cyclopenta[1,2-c]furan-2,4,7(3H,8H)-trione
• 4H,5aH,9H-Furo[2,3-b]furo[3′,2′:2,3]cyclopenta[1,2-c]furan-2,4,7(3H,8H)-trione, 9-(1,1-dimethylethyl)-10,10a-dihydro-8,9-dihydroxy-, (3aS,5aR,8R,8aS,9R,10aS)-
• 4H,5aH,9H-Furo[2,3-b]furo[3′,2′:2,3]cyclopenta[1,2-c]furan-2,4,7(3H,8H)-trione, 9-(1,1-dimethylethyl)-10,10a-dihydro-8,9-dihydroxy-, [5aR-(3aS*,5aα,8β,8aS*,9α,10aα)]-
• 4H,5aH,9H-Furo[2,3-b]furo[3′,2′:2,3]cyclopenta[1,2-c]furan-2,4,7(3H,8H)-trione, 9α-tert-butyl-10,10aβ-dihydro-8α,9-dihydroxy-, (-)-
• Bilobalid
• Bilobalide

Bilobalide

CAS: 33570-04-6

Formula: C₁₅H₁₈O₈

Purity: >96.0%(GC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 326.30

Ref: 3B-B4388

(-)-Bilobalide

CAS: 33570-04-6

(-)-Bilobalide analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Formula: C₁₅H₁₈O₈

Purity: (HPLC) ≥99%

Color and Shape: Powder

Molecular weight: 326.3

Ref: 11-3815S

Bilobalide

CAS: 33570-04-6

Formula: C₁₅H₁₈O₈

Molecular weight: 326.30

Ref: 7W-GP0345

Bilobalide

CAS: 33570-04-6

Bilobalide

Purity: ≥98%

Molecular weight: 326.3g/mol

Ref: 54-BUP00057

Bilobalide A

CAS: 33570-04-6

Formula: C₁₅H₁₈O₈

Purity: 95%~99%

Molecular weight: 326.301

Ref: BP-BP0274

(-)-Bilobalide

CAS: 33570-04-6

Formula: C₁₅H₁₈O₈

Molecular weight: 326.30

Ref: 4Z-B-175001

Bilobalide

CAS: 33570-04-6

Bilobalide ((-)-Bilobalide), a bioactive from Gingko Biloba, is active on hypoxia-induced alterations.

Formula: C₁₅H₁₈O₈

Purity: 98.81% - 99.92%

Color and Shape: White Solid

Molecular weight: 326.30

Ref: TM-T2808

(-)-bilobalide

CAS: 33570-04-6

Lactone

Formula: C₁₅H₁₈O₈

Purity: ≥ 95.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 326.3

Ref: 5G-89167

Bilobalide

Controlled Product

CAS: 33570-04-6

Stability Hygroscopic
Applications Bilobalide provides protection against learning and memory impairment by reducing free radical injury and inhibiting neuronal apoptosis in the brain cortex and hippocampal CA1 region in induced vascular dementia rats.
References Li, W., et. al.: Mol. Med. Reports, 8, 935 (2013)

Formula: C₁₅H₁₈O₈

Color and Shape: Off White

Molecular weight: 326.3

Ref: TR-B386460

Bilobalide

CAS: 33570-04-6

Formula: C₁₅H₁₈O₈

Purity: 95.0%

Molecular weight: 326.301

Ref: 10-F424224

Bilobalide

CAS: 33570-04-6

Formula: C₁₅H₁₈O₈

Color and Shape: Solid

Molecular weight: 326.2986

Ref: IN-DA0037LV

Bilobalide

CAS: 33570-04-6

Bilobalide is a sesquiterpene trilactone, which is a secondary metabolite isolated from the leaves of the Ginkgo biloba tree. The source of bilobalide, Ginkgo biloba, is one of the oldest tree species, extensively studied for its wide array of bioactive compounds. Bilobalide exerts its mode of action predominantly through modulation of various neurotransmitter systems and protection against neuronal injury. It has demonstrated the ability to antagonize the GABAA receptor and inhibit excitotoxicity related to excessive glutamate release, thereby providing neuroprotective effects.

Formula: C₁₅H₁₈O₈

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 326.3 g/mol

Ref: 3D-FB65801