CAS 336113-53-2

Ispinesib

Description:

Ispinesib is a small molecule that functions primarily as a selective inhibitor of the kinesin spindle protein (KSP), which is crucial for mitotic spindle formation during cell division. Its chemical structure features a complex arrangement that contributes to its biological activity, making it a potential candidate for cancer therapy by disrupting mitosis in rapidly dividing cells. Ispinesib has been studied for its efficacy against various cancer types, particularly in preclinical and clinical trials. The compound is characterized by its moderate solubility in organic solvents and relatively low solubility in water, which can influence its bioavailability and pharmacokinetics. Additionally, Ispinesib's mechanism of action involves the inhibition of KSP, leading to cell cycle arrest and apoptosis in cancer cells. As with many investigational drugs, its safety profile and side effects are evaluated during clinical trials to determine its therapeutic potential and optimal dosing regimens. Overall, Ispinesib represents a targeted approach in cancer treatment, focusing on the disruption of cellular processes essential for tumor growth and proliferation.

Formula: C₃₀H₃₃ClN₄O₂

InChI: InChI=1/C30H33ClN4O2/c1-20(2)27(34(17-7-16-32)29(36)23-12-10-21(3)11-13-23)28-33-26-18-24(31)14-15-25(26)30(37)35(28)19-22-8-5-4-6-9-22/h4-6,8-15,18,20,27H,7,16-17,19,32H2,1-3H3/t27-/m1/s1

SMILES: CC(C)[C@H](c1nc2cc(ccc2c(=O)n1Cc1ccccc1)Cl)N(CCCN)C(=O)c1ccc(C)cc1

Synonyms:

• Ispinesib (SB-715992 /CK0238273)
• N-(3-aminopropyl)-N-[(1R)-1-(3-benzyl-7-chloro-4-oxo-quinazolin-2-yl)-2-methyl-propyl]-4-methyl-benzamide
• SB-71599
• Ispinesib
• Unii-bkt5F9C2ni
• CK0238273
• Ispinesib2
• Ispinesib (SB-715992)
• N-(3-Aminopropyl)-N-[(1R)-1-[7-chloro-3,4-dihydro-4-oxo-3-(phenylmethyl)-2-quinazolinyl]-2-methylpropyl]-4-methylbenzamide Ispinesib(SB-715992)
• Ispinesib Mesilate(SB-715992)
• Ispinesib, >=98%
• CS-376
• SB715992 (Ispinesib)
• ISPINESIB;SB-715992;SB715992
• (R)-N-(3-Aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl
• N-(3-Aminopropyl)-N-[(1R)-1-[7-chloro-3,4-dihydro-4-oxo-3-(phenylmethyl)-2-quinazolinyl]-2-methylpropyl]-4-methylbenzamide
• Benzamide, N-(3-aminopropyl)-N-((1R)-1-(7-chloro-3,4-dihydro-4-oxo-3-(phenylmethyl)-2-quinazolinyl)-2-methylpropyl)-4-methyl-
• SB 715992
• BenzaMide, N-(3-aMinopropyl)-N-((1R)-1-(7-chloro-3,4-dihydro-4-oxo-3-(phenylMethyl)-2-quinazolinyl)-2-Methylprop

(R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl]-4-methylbenzamide

CAS: 336113-53-2

Formula: C₃₀H₃₃ClN₄O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 517.0616

Ref: IN-DA00C6FZ

(R)-N-(3-Aminopropyl)-N-(1-(3-Benzyl-7-Chloro-4-Oxo-3,4-Dihydroquinazolin-2-Yl)-2-Methylpropyl)-4-Methylbenzamide

CAS: 336113-53-2

(R)-N-(3-Aminopropyl)-N-(1-(3-Benzyl-7-Chloro-4-Oxo-3,4-Dihydroquinazolin-2-Yl)-2-Methylpropyl)-4-Methylbenzamide

Purity: 98%

Molecular weight: 517.06g/mol

Ref: 54-OR1023170

Ispinesib

CAS: 336113-53-2

Ispinesib

Purity: ≥98%

Molecular weight: 517.06g/mol

Ref: 54-BUP06976

Ispinesib

CAS: 336113-53-2

Ispinesib (SB-715992), a selective, effectvie and reversible inhibitor of kinesin spindle protein (KSP), is derived from quinazolinone, with antineoplastic

Formula: C₃₀H₃₃ClN₄O₂

Purity: 98% - 99.09%

Color and Shape: Solid

Molecular weight: 517.06

Ref: TM-T2103

Ispinesib

CAS: 336113-53-2

Inhibits mitotic kinesin spindle protein (KSP); antineoplastic

Formula: C₃₀H₃₃ClN₄O₂

Purity: Min. 95%

Color and Shape: Solid

Molecular weight: 517.06 g/mol

Ref: 3D-FI24737

Ispinesib

Controlled Product

CAS: 336113-53-2

Applications Ispinesib is the first potent, highly specific small-molecule inhibitor of KSP tested for the treatment of human disease. Anticancer agent.
References Blangy, A., et al.: J. Biol. Chem., 272, 19418 (1997), Wood, K., et al.: Curr. Opin. Pharmacol., 1, 370 (2001), Sakowicz, R., et al.: Cancer Res., 64, 3276 (2004), Cochran, J., et al.: J. Biol. Chem., 280, 12658 (2005), Kapitein, L., et al.: Nature, 435, 114 (2005),

Formula: C₃₀H₃₃ClN₄O₂

Color and Shape: Neat

Molecular weight: 517.06

Ref: TR-I918500