CAS 336113-53-2: Ispinesib

Description: Ispinesib is a small molecule that functions primarily as a selective inhibitor of the kinesin spindle protein (KSP), which is crucial for mitotic spindle formation during cell division. Its chemical structure features a complex arrangement that contributes to its biological activity, making it a potential candidate for cancer therapy by disrupting mitosis in rapidly dividing cells. Ispinesib has been studied for its efficacy against various cancer types, particularly in preclinical and clinical trials. The compound is characterized by its moderate solubility in organic solvents and relatively low solubility in water, which can influence its bioavailability and pharmacokinetics. Additionally, Ispinesib's mechanism of action involves the inhibition of KSP, leading to cell cycle arrest and apoptosis in cancer cells. As with many investigational drugs, its safety profile and side effects are evaluated during clinical trials to determine its therapeutic potential and optimal dosing regimens. Overall, Ispinesib represents a targeted approach in cancer treatment, focusing on the disruption of cellular processes essential for tumor growth and proliferation.

Formula: C₃₀H₃₃ClN₄O₂

InChI: InChI=1/C30H33ClN4O2/c1-20(2)27(34(17-7-16-32)29(36)23-12-10-21(3)11-13-23)28-33-26-18-24(31)14-15-25(26)30(37)35(28)19-22-8-5-4-6-9-22/h4-6,8-15,18,20,27H,7,16-17,19,32H2,1-3H3/t27-/m1/s1

Synonyms:

• Ispinesib (SB-715992 /CK0238273)
• N-(3-aminopropyl)-N-[(1R)-1-(3-benzyl-7-chloro-4-oxo-quinazolin-2-yl)-2-methyl-propyl]-4-methyl-benzamide

Ispinesib

CAS: 336113-53-2

• Formula: C₃₀H₃₃ClN₄O₂
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 517.06162

(R)-N-(3-Aminopropyl)-N-(1-(3-Benzyl-7-Chloro-4-Oxo-3,4-Dihydroquinazolin-2-Yl)-2-Methylpropyl)-4-Methylbenzamide

CAS: 336113-53-2

• Purity: 98%
• Molecular weight: 517.06g/mol

Ispinesib

CAS: 336113-53-2

• Purity: ≥98%
• Molecular weight: 517.06g/mol

Ispinesib

CAS: 336113-53-2

Ispinesib (SB-715992), a selective, effectvie and reversible inhibitor of kinesin spindle protein (KSP), is derived …

• Formula: C₃₀H₃₃ClN₄O₂
• Purity: 98% - 98.59%
• Color and Shape: Solid
• Molecular weight: 517.06

Ispinesib

CAS: 336113-53-2

Inhibits mitotic kinesin spindle protein (KSP); antineoplastic

• Formula: C₃₀H₃₃ClN₄O₂
• Purity: Min. 95%
• Color and Shape: Solid
• Molecular weight: 517.06 g/mol

Ispinesib

CAS: 336113-53-2

Applications Ispinesib is the first potent, highly specific small-molecule inhibitor of KSP tested for the …

• Formula: C₃₀H₃₃ClN₄O₂
• Color and Shape: Neat
• Molecular weight: 517.06