CAS 337-02-0

(11β,16α)-9-Fluoro-11,16,17,21-tetrahydroxypregn-4-ene-3,20-dione

Description:

The chemical substance known as (11β,16α)-9-Fluoro-11,16,17,21-tetrahydroxypregn-4-ene-3,20-dione, with the CAS number 337-02-0, is a synthetic corticosteroid. It is characterized by its fluorinated structure, which enhances its anti-inflammatory and immunosuppressive properties. This compound features multiple hydroxyl groups, contributing to its solubility and biological activity. It is primarily used in the treatment of various inflammatory and autoimmune conditions due to its potent glucocorticoid activity. The presence of the fluorine atom at the 9-position increases its receptor affinity and metabolic stability. As a steroid, it exhibits a characteristic four-ring core structure typical of steroid hormones, which is crucial for its interaction with glucocorticoid receptors. The compound's pharmacological effects include modulation of gene expression, inhibition of inflammatory mediators, and regulation of immune responses. Due to its potent effects, it is essential to use this substance under medical supervision to mitigate potential side effects associated with corticosteroid therapy.

Formula: C₂₁H₂₉FO₆

InChI: InChI=1S/C21H29FO6/c1-18-6-5-12(24)7-11(18)3-4-13-14-8-15(25)21(28,17(27)10-23)19(14,2)9-16(26)20(13,18)22/h7,13-16,23,25-26,28H,3-6,8-10H2,1-2H3/t13-,14-,15+,16-,18-,19-,20-,21-/m0/s1

InChI key: InChIKey=SXQQMCLQCSKJNC-OBYCQNJPSA-N

SMILES: F[C@@]12[C@]([C@]3([C@](C)(C[C@@H]1O)[C@](C(CO)=O)(O)[C@H](O)C3)[H])(CCC=4[C@]2(C)CCC(=O)C4)[H]

Synonyms:

• (11Beta,16Alpha)-9-Fluoro-11,16,17,21-Tetrahydroxypregn-4-Ene-3,20-Dione
• (11β,16α)-9-Fluoro-11,16,17,21-tetrahydroxypregn-4-ene-3,20-dione
• 9-Fluoro-11,16,17,21-Tetrahydroxypregn-4-Ene-3,20-Dione
• 9-Fluoro-11beta,16alpha,17,21-tetrahydroxypregn-4-ene-3,20-dione
• 9α-Fluoro-11β,16α,17α,21-tetrahydroxypregn-4-ene-3,20-dione
• 9α-Fluoro-16α-hydroxyhydrocortisone
• Corticosterone, 9-fluoro-16α,17-dihydroxy-
• NSC 21913
• Pregn-4-ene-3,20-dione, 9-fluoro-11,16,17,21-tetrahydroxy-, (11β,16α)-
• Pregn-4-ene-3,20-dione, 9-fluoro-11β,16α,17,21-tetrahydroxy-

TRIAMCINOLONE IMPURITY C CRS

CAS: 337-02-0

TRIAMCINOLONE IMPURITY C CRS

Ref: 41-Y0000050

Triamcinolone EP Impurity C (Pretriamcinolone)

CAS: 337-02-0

Formula: C₂₁H₂₉FO₆

Color and Shape: White To Off-White Solid

Molecular weight: 396.46

Ref: 4Z-T-5310

1,2-Dihydro Triamcinolone

Controlled Product

CAS: 337-02-0

Applications 1,2-Dihydro Triamcinolone is a derivative of Triamcinolone (T767165), a glucocorticoid, antiasthmatic (inhalant); antiallergic (nasal).
References Florey, K., et al.: Anal. Profiles Drug Subs., 1, 397 (1972); Bernstein, I.L., et al.: Chest, 81, 20 (1982);

Formula: C₂₁H₂₉FO₆

Color and Shape: Neat

Molecular weight: 396.45

Ref: TR-D453393

Triamcinolone EP Impurity C

CAS: 337-02-0

Formula: C₂₁H₂₉FO₆

Molecular weight: 396.46

Ref: ST-EA-CP-T98003