CAS 337376-15-5

Icodextrin

Description:

Icodextrin is a synthetic carbohydrate derived from the enzymatic hydrolysis of starch, primarily used in medical applications, particularly in peritoneal dialysis solutions. It is a glucose polymer composed of various chain lengths, which contributes to its unique properties. Icodextrin is characterized by its ability to create an osmotic gradient, facilitating the removal of excess fluid from the body while minimizing the risk of glucose-related complications. It is typically presented as a clear, colorless solution and is known for its biocompatibility and low immunogenicity. The substance is stable under normal conditions and has a relatively low molecular weight, which allows for efficient absorption and excretion. Additionally, Icodextrin has a low caloric value, making it suitable for patients requiring fluid management without significant caloric intake. Its use in clinical settings has been associated with improved patient outcomes in dialysis, particularly in terms of ultrafiltration and fluid balance. Overall, Icodextrin represents a significant advancement in the management of patients undergoing peritoneal dialysis.

Formula: Unspecified

InChI: InChI=1/C46H62N4O11/c1-22(2)21-50-18-16-46(17-19-50)48-34-31-32-39(54)28(8)42-33(31)43(56)45(10,61-42)59-20-15-30(58-11)25(5)41(60-29(9)51)27(7)38(53)26(6)37(52)23(3)13-12-14-24(4)44(57)47-36(40(32)55)35(34)49-46/h12-15,20,22-23,25-27,30,37-38,41,49,52-54H,16-19,21H2,1-11H3,(H,47,57)/b13-12-,20-15-,24-14-/t23-,25-,26+,27+,30-,37-,38+,41-,45+/m1/s1

Synonyms:

• (11beta,16beta)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
• 3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide
• A complex polyglucopyranose produced by the enzymatic hydrolysis of corn. It is primarily composed of alpha-1,4-glocopyranose linkage with less that 10 percent alpha-1,6 linkage
• platinum
• Adept (polysaccharide)
• 1-cyano-2-methyl-3-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl)guanidine
• (3S)-2-{N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
• A complex alpha-D-glycopyranan produced by the enzymatic hydrolysis of corn. It is primarily composed of (1-4)-alpha-D-glucopyrano linkage with less than 10 percent (1-6)-alpha linkage. Dextrin, having more than 85% of its molecules with molecular masses between 1640 and 45,000 with a claimed-average molecular mass of approximately 20,000
• 2-(2,4-difluorophenyl)-1,3-di(1H-1,2,4-triazol-1-yl)propan-2-ol
• 1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
• [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]{4-[2-(piperidin-1-yl)ethoxy]phenyl}methanone
• 1-{2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
• (11beta)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione
• N-(piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide
• azanide
• 2-(butan-2-yl)-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one
• A complex polyglucopyranose produced by the enzymatic hydrolysis of corn. It is primarily composed of alpha-1,4-glocopyranose linkage with less that 10 percent alpha-1,6 linkage
• 1-{amino[(4-chlorophenyl)amino]methylidene}-2-propan-2-ylguanidine
• (11beta,16beta)-9-chloro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
• 3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-1-amine
• 3-[({2-[(diaminomethylidene)amino]-1,3-thiazol-4-yl}methyl)sulfanyl]-N'-sulfamoylpropanimidamide
• 2-phenyl-1H-indene-1,3(2H)-dione
• 1-[4-(4-{[(2S,4R)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethanone
• Icodextrin
• 2-benzyl-4,5-dihydro-1H-imidazole
• 5-ethyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione
• 1-methyl-1,3-dihydro-2H-imidazole-2-thione
• methyl (3beta,16beta,17alpha,18beta,20alpha)-11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylate
• (6R,7R)-7-{[amino(phenyl)acetyl]amino}-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 1-(9H-carbazol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-ol
• 5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}quinazoline-2,4-diamine
• Icodial
• 2-(diethylamino)ethyl 1,1'-bi(cyclohexyl)-1-carboxylate
• N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide
• 1-(1,2-benzoxazol-3-yl)methanesulfonamide
• 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one
• 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
• (2S,5R,6R)-6-{[(2R)-2-amino-2-phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• 1-methyl-3-phenylpyrrolidine-2,5-dione
• 5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one
• Icodextrin, sodium chloride, sodium lactate, calcium chloride
• 1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene
• N,N-dimethyl-2-[(2-methylphenyl)(phenyl)methoxy]ethanamine
• 2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one
• N~4~-(7-chloroquinolin-4-yl)-N~1~,N~1~-diethylpentane-1,4-diamine
• 2-(hydroxymethyl)-4-(1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl)phenol
• 1-cyclohexyl-1-phenyl-3-(pyrrolidin-1-yl)propan-1-ol
• ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate
• (6R,7R)-3-[(carbamoyloxy)methyl]-7-{[(2E)-2-furan-2-yl-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 1,3-dibenzyl-2-oxodecahydrothieno[1',2':1,2]thieno[3,4-d]imidazol-5-ium
• 5-[bis(2-chloroethyl)amino]pyrimidine-2,4(1H,3H)-dione
• 5-[3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydroquinolin-2(1H)-one
• N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine
• Adept
• 5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diamine
• N,N-dimethyl-3-(10H-phenothiazin-10-yl)propan-1-amine
• Adept (polysaccharide)
• 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine
• 2-methyl-6-oxo-1,6-dihydro-3,4'-bipyridine-5-carbonitrile
• ethyl 1-methyl-4-phenylpiperidine-4-carboxylate
• 7',12'-dihydroxy-6,6'-dimethoxy-2,2',2'-trimethyltubocuraran-2'-ium
• (2S,3aS,6aS)-1-[(2S)-2-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid (non-preferred name)
• 2-amino-1-(2,5-dimethoxyphenyl)propan-1-ol
• N-[4-(acridin-9-ylamino)-3-methoxyphenyl]methanesulfonamide
• cyclobutane-1,1-dicarboxylic acid
• (5Z,7E,22E)-9,10-secoergosta-5,7,22-trien-3-ol
• 5,5-diphenylimidazolidine-2,4-dione
• 4-amino-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide
• 2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl acetate
• N,N,2-trimethyl-3-(10H-phenothiazin-10-yl)propan-1-amine
• Adept
• N,2,3,3-tetramethylbicyclo[2.2.1]heptan-2-amine
• 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine
• (11beta,17beta)-11-[4-(dimethylamino)phenyl]-17-hydroxy-17-(prop-1-yn-1-yl)estra-4,9-dien-3-one
• (5alpha,6alpha)-17-methyl-7,8-didehydro-4,5-epoxymorphinan-3,6-diol
• 2-[(carbamoyloxy)methyl]-2-methylpentyl propan-2-ylcarbamate (non-preferred name)
• 2-chloro-N-(2-chloroethyl)-N-methylethanamine
• 3-ethyl-4-methyl-N-[2-(4-{[(4-methylcyclohexyl)carbamoyl]sulfamoyl}phenyl)ethyl]-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide
• (17beta)-estra-1,3,5(10)-triene-3,17-diol
• 5-fluoropyrimidine-2,4(1H,3H)-dione
• methyl propan-2-yl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
• 17,21-dihydroxypregna-1,4-diene-3,11,20-trione
• 3,7-dimethyl-1-(5-oxohexyl)-3,7-dihydro-1H-purine-2,6-dione
• 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium
• 2-[({5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene}amino)oxy]ethanamine
• 2-{(Z)-[5-(hydroxymethyl)-3H-indol-3-ylidene]methyl}-N'-pentylhydrazinecarboximidamide
• [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl](2,3-dihydro-1,4-benzodioxin-2-yl)methanone
• 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
• 2-{4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazin-1-yl}ethanol
• 4-(dipropylsulfamoyl)benzoic acid
• 1-[(2S)-2-methyl-3-sulfanylpropanoyl]-L-proline
• Extraneal
• (1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-arabino-hexopyranoside
• (8R)-3-(2-deoxypentofuranosyl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol
• (4Z)-4-(3,3-dimethyltriazanylidene)-4H-imidazole-5-carboxamide
• 9-(beta-D-arabinofuranosyl)-9H-purin-6-amine hydrate (1:1)
• (1R,5R)-3-[(3-hydroxy-2-phenylpropanoyl)oxy]-8-methyl-8-(propan-2-yl)-8-azoniabicyclo[3.2.1]octane
• platinum(2+) ethanedioate - cyclohexane-1,2-diamine (1:1:1)
• 6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate
• 4-amino-N-[2-(diethylamino)ethyl]benzamide
• N,3-bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide
• 4-(2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)benzene-1,2-diol
• (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
• 2-[benzyl(methyl)amino]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• (1S,3S)-3-acetyl-3,5,12-trihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside
• 4-{[(E)-(4-chlorophenyl)(3-fluoro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino}butanamide
• 3-ethyl-3-methylpyrrolidine-2,5-dione
• 4-(diethylamino)but-2-yn-1-yl cyclohexyl(hydroxy)phenylacetate
• (3S)-9,10-secocholesta-5,7,10-trien-3-ol
• 9-methyl-3-(2H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one
• 2-[(1E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-en-1-yl]pyridine
• 4-chloro-N-(propylcarbamoyl)benzenesulfonamide
• (2S,5R,6R)-6-{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• 2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-5-ethyl-4-(2-phenoxyethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one
• (5alpha)-3,14-dihydroxy-17-methyl-4,5-epoxymorphinan-6-one
• N-[(1R)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl-L-proline
• ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylate
• N~2~-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-L-proline
• 5-{4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromen-2-yl)methoxy]benzyl}-1,3-thiazolidine-2,4-dione
• 6-phenylpteridine-2,4,7-triamine
• 3-(dibutylamino)-1-[1,3-dichloro-6-(trifluoromethyl)phenanthren-9-yl]propan-1-ol
• 1-{[(1Z)-(5-nitrofuran-2-yl)methylidene]amino}imidazolidine-2,4-dione
• ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• 4-aminohex-5-enoic acid
• 2,2'-[(1R,2R,3S,4R,5R,6S)-4-({5-deoxy-2-O-[2-deoxy-2-(methylamino)-alpha-L-glucopyranosyl]-3-C-formyl-alpha-L-lyxofuranosyl}oxy)-2,5,6-trihydroxycyclohexane-1,3-diyl]diguanidine
• (6R,7R)-7-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-8-oxo-3-[(1E)-prop-1-en-1-yl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 1-(beta-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide
• 2-[(5-nitrofuran-2-yl)methylidene]hydrazinecarboxamide
• 2-O-sulfohexopyranuronosyl-(1->4)-2-deoxy-3-O-sulfo-2-(sulfoamino)hexopyranosyl-(1->4)-2-O-sulfohexopyranuronosyl-(1->4)-2-(acetylamino)-2-deoxy-6-O-sulfohexopyranose
• 3-[(1R,2S)-2-amino-1-hydroxypropyl]phenol
• methyl (5S,7S,9S)-9-[(2beta,3beta,4beta,5alpha,12beta,19alpha)-3-carbamoyl-3,4-dihydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidin-15-yl]-5-ethyl-5-hydroxy-1,4,5,6,7,8,9,10-octahydro-2H-3,7-methanoazacycloundecino[5,4-b]indole-9-carboxylate
• [2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid
• (3S)-N-methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine
• 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
• 2,2'-hexane-1,6-diylbis(1-{amino[(4-chlorophenyl)amino]methylidene}guanidine)
• [(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate (non-preferred name)
• (3E)-6-oxo-3-{[4-(pyridin-2-ylsulfamoyl)phenyl]hydrazono}cyclohexa-1,4-diene-1-carboxylic acid
• 5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]imidazolidine-2,4-dione
• propan-2-yl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate
• N,N-bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide
• 2,2'-[(1,4-dioxobutane-1,4-diyl)bis(oxy)]bis(N,N,N-trimethylethanaminium)
• 3-cyclohexyl-N,N,N-triethyl-3-hydroxy-3-phenylpropan-1-aminium
• 2-{4-[(1Z)-4-chloro-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine
• [(3S)-3-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid
• (9S,12Z,14R,15R,16S,17S,18S,19S,20R,21R,22Z,24Z)-6,18,20-trihydroxy-14-methoxy-7,9,15,17,19,21,25-heptamethyl-1'-(2-methylpropyl)-5,10,26-trioxo-3,5,9,10-tetrahydrospiro[9,4-(epoxypentadeca[1,11,13]trienoimino)furo[2',3':7,8]naphtho[1,2-d]imidazole-2,4'-piperidin]-16-yl acetate
• 1-{4-[2-(cyclopropylmethoxy)ethyl]phenoxy}-3-(propan-2-ylamino)propan-2-ol
• 8-chloro-11-(4-methylpiperazin-1-yl)-10H-dibenzo[b,e][1,4]diazepine
• (1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid
• (3Z)-3-[hydroxy(pyridin-2-ylamino)methylidene]-2-methyl-2,3-dihydro-4H-thieno[2,3-e][1,2]thiazin-4-one 1,1-dioxide
• 2'-deoxy-5-iodouridine
• (5alpha)-3,14-dihydroxy-17-prop-2-en-1-yl-4,5-epoxymorphinan-6-one
• 4-amino-1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2(1H)-one
• 4-[(3-methylphenyl)amino]-N-(propan-2-ylcarbamoyl)pyridine-3-sulfonamide
• (1S)-1-{[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]methyl}dodecyl N-formyl-L-leucinate
• 2-amino-9-[(2-hydroxyethoxy)methyl]-3,9-dihydro-6H-purin-6-one
• 4-amino-5-chloro-N-{1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-yl}-2-methoxybenzamide
• N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine
• N-{3-[(4-amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino]propyl}tetrahydrofuran-2-carboxamide
• 5-chloro-1,3-benzoxazol-2(3H)-one
• 5-ethyl-3-methyl-5-phenylimidazolidine-2,4-dione
• (11E)-13-[(2S,3R,4R,5S)-3,4-dihydroxy-5-({(2R,3S)-3-[(1S,2S)-2-hydroxy-1-methylpropyl]oxiran-2-yl}methyl)tetrahydro-2H-pyran-2-yl]-12-methyl-10-oxotridec-11-enoic acid (non-preferred name)

Icodextrin

CAS: 337376-15-5

Purity: 95%

Color and Shape: Solid

Molecular weight: G/Mol

Ref: IN-DA0037O4