CAS 337536-53-5

Guanosine, 8-nitro-

Description:

Guanosine, 8-nitro- is a modified nucleoside that features a nitro group (-NO2) attached to the 8-position of the guanine base. This compound is part of the broader category of nucleosides, which are essential building blocks of nucleic acids like RNA and DNA. The presence of the nitro group can influence the chemical properties and biological activities of the molecule, potentially affecting its role in cellular processes. Guanosine itself is composed of a guanine base linked to a ribose sugar, and the modification at the 8-position may alter its interactions with enzymes, receptors, or other nucleic acids. Such modifications can also impact its stability, solubility, and reactivity. Research into nitro-substituted nucleosides like guanosine, 8-nitro- may provide insights into their potential applications in medicinal chemistry, particularly in the development of therapeutics targeting nucleic acid structures or functions. Overall, the unique characteristics of this compound make it a subject of interest in both chemical and biological research.

Formula: C₁₀H₁₂N₆O₇

InChI: InChI=1S/C10H12N6O7/c11-9-13-6-3(7(20)14-9)12-10(16(21)22)15(6)8-5(19)4(18)2(1-17)23-8/h2,4-5,8,17-19H,1H2,(H3,11,13,14,20)/t2-,4-,5-,8-/m1/s1

InChI key: InChIKey=KGUOMRFOXYDMAH-UMMCILCDSA-N

SMILES: N(=O)(=O)C=1N(C2=C(N1)C(=O)N=C(N)N2)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O

Synonyms:

• 8-Nitroguanosine
• Guanosine, 8-nitro-

8-Nitroguanosine

CAS: 337536-53-5

Ref: 7W-GN4329

8-Nitroguanosine

CAS: 337536-53-5

8-Nitroguanosine is a Nucleoside Derivative - 8-Modified purine nucleoside.

Formula: C₁₀H₁₂N₆O₇

Color and Shape: Solid

Molecular weight: 328.24

Ref: TM-TNU0191

8-Nitroguanosine

Controlled Product

CAS: 337536-53-5

Applications A highly reactive redox-active nucleic acid derivative that is formed in cellular RNA as biomarker of exposure to reactive nitrogen species. Recent studies suggest that it might contribute to the pathogenesis of inflammation-associated carcinogenesis.
References Sawa, T. et al.: Biochem. Biophys. Res. Comm., 311, 300 (2003); Masuda, M. et al.: Chem.-Biol. Inter., 139, 187 (2002); Kaneko, K. et al.: Cancer Lett., 262, 239 (2008);

Formula: C₁₀H₁₂N₆O₇

Color and Shape: Neat

Molecular weight: 328.24

Ref: TR-N496050

8-Nitroguanosine

CAS: 337536-53-5

8-Nitroguanosine is a nucleotide analogue that inhibits the activity of cyclic GMP in cells. It has been found to inhibit the growth of bacteria and cancer cells, as well as to stimulate the production of reactive oxygen species in brain cells. 8-Nitroguanosine has also been shown to inhibit the activity of cyclase enzymes in liver cells, which may be useful for treating liver disease. 8-Nitroguanosine is used as a chemical base for monoclonal antibodies that are used to study brain functions and pathogenic mechanisms.

Formula: C₁₀H₁₂N₆O₇

Purity: Min. 95%

Molecular weight: 328.24 g/mol

Ref: 3D-NN03322