CAS 33823-18-6

Adenosine,8-(methylamino)-, cyclic 3',5'-(hydrogen phosphate)

Description:

Adenosine, 8-(methylamino)-, cyclic 3',5'-(hydrogen phosphate), commonly referred to as a cyclic nucleotide, is a derivative of adenosine that plays a crucial role in cellular signaling and metabolism. This compound features a cyclic structure formed by the phosphate group linking the 3' and 5' hydroxyl groups of the ribose sugar, which is characteristic of cyclic nucleotides. The presence of a methylamino group at the 8-position of the adenine base enhances its biological activity and may influence its interaction with various receptors and enzymes. Cyclic nucleotides, including this compound, are involved in numerous physiological processes, such as signal transduction pathways, regulation of enzyme activity, and modulation of ion channels. They are also important in the context of pharmacology and biochemistry, as they can serve as second messengers in various signaling cascades. The compound's stability, solubility, and reactivity are influenced by its structural features, making it a subject of interest in both research and therapeutic applications.

Formula: C₁₁H₁₅N₆O₆P

Synonyms:

• 9H-Purine,6-amino-8-(methylamino)-9-b-D-ribofuranosyl-, cyclic 3',5'-(hydrogen phosphate) (8CI)
• 4H-Furo[3,2-d]-1,3,2-dioxaphosphorin, adenosine deriv.
• 8-Methylamino cyclicAMP
• 8-Methylamino-cAMP
• 8-Methylaminoadenosine 3',5'-monophosphate
• 8-Methylaminoadenosine cyclic 3',5'-monophosphate

8-MA-cAMP

CAS: 33823-18-6

8-MA-cAMP (8-Methylamino-cAMP) is a cyclic adenosine monophosphate analog that acts as a site-selective PKA agonist, exhibiting similar affinity for the B site of both Type I and Type II protein kinase A. When used in conjunction with analogs that preferentially target site A, such as 8-piperidinyl cAMP, 8-MA-cAMP facilitates selective stimulation of Type I enzymes.

Formula: C₁₁H₁₅N₆O₆P

Color and Shape: Solid

Molecular weight: 358.25

Ref: TM-T88462