CAS 33889-68-8

Fangchinoline

Description:

Fangchinoline is an alkaloid compound primarily derived from the plant species *Stephania* and is known for its diverse biological activities. It is characterized by its complex tetracyclic structure, which contributes to its pharmacological properties. Fangchinoline exhibits a range of effects, including anti-inflammatory, analgesic, and potential anticancer activities, making it a subject of interest in medicinal chemistry. The compound has been studied for its ability to modulate various biological pathways, including those involved in cell proliferation and apoptosis. Additionally, fangchinoline has shown promise in traditional medicine, particularly in Asian herbal practices. Its solubility and stability can vary depending on the solvent and environmental conditions, which are important factors for its application in research and therapeutic contexts. As with many natural products, further studies are needed to fully elucidate its mechanisms of action and potential therapeutic uses. Safety and toxicity profiles are also critical areas of investigation to ensure its viability for clinical applications.

Formula: C₃₇H₄₀N₂O₆

InChI: InChI=1/C37H40N2O6/c1-38-14-12-24-19-31(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-32-18-23(8-11-30(32)41-3)17-29-35-25(13-15-39(29)2)20-34(43-5)36(40)37(35)45-33/h6-11,18-21,28-29,40H,12-17H2,1-5H3

SMILES: CN1CCc2cc(c3cc2C1Cc1ccc(cc1)Oc1cc(ccc1OC)CC1c2c(CCN1C)cc(c(c2O3)O)OC)OC

Synonyms:

• (+)-Hanfangichin B
• 6,6',12-Trimethoxy-2,2'-Dimethylberbaman-7-Ol
• (1beta)-6,6',12-Trimethoxy-2,2'-dimethylberbaman-7-ol

(11S,31R)-16,36,54-Trimethoxy-12,32-dimethyl-11,12,13,14,31,32,33,34-octahydro-2,6-dioxa-1(7,1),3(8,1)-diisoquinolina-5(1,3),7(1,4)-dibenzenacyclooctaphan-37-ol

CAS: 33889-68-8

Formula: C₃₇H₄₀N₂O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 608.7233

Ref: IN-DA00C7TV

(R)-Fangchinoline

CAS: 33889-68-8

(R)-Fangchinoline

Purity: ≥98%

Molecular weight: 608.72g/mol

Ref: 54-BUP06904

(R)-Fangchinoline

CAS: 33889-68-8

(R)-Fangchinoline ((+)-Thalrugosine) is extracted from Stephania tetrandra S. Moore.

Formula: C₃₇H₄₀N₂O₆

Purity: 98% - 99.83%

Color and Shape: Solid

Molecular weight: 608.72

Ref: TM-T2809

Fangchinoline

CAS: 33889-68-8

Fangchinoline is a natural product that has been shown to have anticancer properties. It has been shown to inhibit the growth of human osteosarcoma cells in vitro and in vivo. Fangchinoline also induces autophagy, which is a process by which cells degrade damaged organelles and protein aggregates via lysosomes. Fangchinoline inhibits cancer cell growth by interfering with the G2-M phase transition, thereby preventing the production of cyclin D2 and inhibiting DNA synthesis by blocking polymerase chain reaction. Fangchinoline also blocks matrix metalloproteinases (MMPs) and increases the activity of tissue inhibitors of metalloproteinases (TIMPs), which are enzymes that regulate MMP activity. When fangchinoline binds to TIMP-1, it prevents its binding to MMP-9 and other pro-metalloproteinases, thereby reducing their activity. Fangchinoline can be synthesized from Stephania

Formula: C₃₇H₄₀N₂O₆

Purity: Min. 95%

Molecular weight: 608.72 g/mol

Ref: 3D-FF32810

Fangchinoline

Controlled Product

CAS: 33889-68-8

Applications Fangchinoline is an isolate from Stephania Tetrandra that shows anti-cancer activity. It inhibits breast adenocarcinoma proliferation through apoptosis induction. In addition, it has been shown to inhibit HIV-Type 1 replication.
References Xing, Z. et al.: Chem. Pharm. Bull., 59, 1476 (2011); Wan, Z. et al.: PLoS One. 7, e39225 (2012);

Formula: C₃₇H₄₀N₂O₆

Color and Shape: Neat

Molecular weight: 608.72

Ref: TR-F102365