CAS 339177-26-3

Immunoglobulin, anti-(human epidermal growth factor receptor) (human monoclonal ABX-EGF heavy chain), disulfide with human monoclonal ABX-EGF light chain, dimer

Description:

Immunoglobulin, anti-(human epidermal growth factor receptor) (human monoclonal ABX-EGF heavy chain), disulfide with human monoclonal ABX-EGF light chain, dimer, is a monoclonal antibody designed to target the human epidermal growth factor receptor (EGFR), which plays a crucial role in cell proliferation and survival. This antibody is composed of two heavy chains and two light chains linked by disulfide bonds, forming a dimeric structure that enhances its stability and binding affinity. The specificity of this antibody for EGFR makes it a valuable tool in cancer therapy, particularly for tumors that overexpress this receptor. Its mechanism of action typically involves blocking the receptor's activation by its natural ligands, thereby inhibiting downstream signaling pathways that promote tumor growth. Additionally, this immunoglobulin may be utilized in diagnostic applications to detect EGFR expression levels in various tissues. As a therapeutic agent, it is important to consider its pharmacokinetics, potential immunogenicity, and the development of resistance in target cells. Overall, this monoclonal antibody represents a significant advancement in targeted cancer treatment strategies.

Panitumumab

CAS: 339177-26-3

Panitumumab is a fully human IgG2 monoclonal antibody targeting the epidermal growth factor receptor EGFR).

Purity: 95% - 98.1% (SDS-PAGE); 99.4% (SEC-HPLC)

Color and Shape: Liquid

Molecular weight: 147 kDa

Ref: TM-T9927

Panitumumab - buffer solution

CAS: 339177-26-3

Monoclonal antibody against EGFR

Formula: C₆₃₉₈H₉₈₇₈N₁₆₉₄O₂₀₁₆S₄₈

Purity: Min. 95 Area-%

Color and Shape: Colorless Clear Liquid

Molecular weight: 144.3 g/mol

Ref: 3D-FP30153