CAS 34157-83-0

Celastrol

Description:

Celastrol is a naturally occurring triterpenoid compound derived from the root of the Thunder God Vine (Tripterygium wilfordii). It is characterized by its complex molecular structure, which includes a pentacyclic triterpene framework. Celastrol exhibits a range of biological activities, including anti-inflammatory, antioxidant, and anticancer properties, making it a subject of interest in pharmacological research. The compound has been shown to modulate various signaling pathways, including those involved in the regulation of heat shock proteins and the NF-κB pathway, contributing to its therapeutic potential. Celastrol is typically found as a yellow crystalline solid and is soluble in organic solvents like dimethyl sulfoxide (DMSO) but has limited solubility in water. Its chemical formula is C30H48O3, and it has a molecular weight of approximately 456.7 g/mol. Due to its potent biological effects, celastrol is being investigated for its potential use in treating conditions such as cancer, obesity, and autoimmune diseases, although further studies are needed to fully understand its mechanisms and therapeutic applications.

Formula: C₂₉H₃₈O₄

InChI: InChI=1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,31H,9-14,16H2,1-6H3,(H,32,33)/t22-,25-,26-,27+,28-,29+/m1/s1

InChI key: InChIKey=KQJSQWZMSAGSHN-JJWQIEBTSA-N

SMILES: C[C@@]12[C@](C)([C@]3([C@@](C)(CC1)CC[C@](C(O)=O)(C)C3)[H])CC[C@]4(C)C2=CC=C5C4=CC(=O)C(O)=C5C

Synonyms:

• (2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid
• (2R,4aS,6aS,6aR,14aS,14bR)-10-Hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid
• (9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid
• 2-Picenecarboxylic acid, 1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-, (2R,4aS,6aS,12bR,14aS,14bR)-
• 2-Picenecarboxylic acid, 1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-, [2R-(2α,4aβ,6aβ,12bβ,14aα,14bβ)]-
• 24,25,26-Trinoroleana-1(10),3,5,7-tetraen-29-oic acid, 3-hydroxy-9,13-dimethyl-2-oxo-, (9β,13α,14β,20α)-
• 24-Nor-D:A-friedooleana-1(10),3,5,7-tetraen-29-oic acid, 3-hydroxy-2-oxo-
• D:A-Friedo-24-noroleana-1(10),3,5,7-tetraen-29-oic acid, 3-hydroxy-2-oxo-, (20α)-
• NSC 70931
• Tripterin
• Ui1590

Celastrol

CAS: 34157-83-0

Formula: C₂₉H₃₈O₄

Purity: >98.0%(HPLC)

Color and Shape: Light yellow to Amber to Dark green powder to crystal

Molecular weight: 450.62

Ref: 3B-C2737

Celastrol

CAS: 34157-83-0

Celastrol

Formula: C₂₉H₃₈O₄

Purity: 98%

Color and Shape: red powder

Molecular weight: 450.61g/mol

Ref: 54-BIC1002

Tripterin

CAS: 34157-83-0

Tripterin

Purity: ≥98%

Molecular weight: 450.61g/mol

Ref: 54-BUP06297

Celastrol

CAS: 34157-83-0

Formula: C₂₉H₃₈O₄

Purity: 95%~99%

Molecular weight: 450.619

Ref: BP-BP0327

Tripterin

CAS: 34157-83-0

Tripterin (Celastrol) is an proteasome inhibitor for the chymotrypsin-like activity of a purified 20S proteasome with antioxidant and anti-inflammatory effects.

Formula: C₂₉H₃₈O₄

Purity: 98.56% - 99.8%

Color and Shape: Red Crystalline Powder

Molecular weight: 450.61

Ref: TM-T3028

Celastrol

CAS: 34157-83-0

Formula: C₂₉H₃₈O₄

Purity: ≥ 98.0%

Color and Shape: Red to dark red powder

Molecular weight: 450.61

Ref: 7W-GP7348

Celastrol

CAS: 34157-83-0

Carboxylic acid with additional oxygen functions

Formula: C₂₉H₃₈O₄

Purity: ≥ 95.0 % (HPLC)

Color and Shape: Crystalline

Molecular weight: 450.62

Ref: 5G-80381

Celastrol (>85%)

CAS: 34157-83-0

Formula: C₂₉H₃₈O₄

Purity: >85%

Color and Shape: Neat

Ref: TR-C249510

Celastrol

Controlled Product

CAS: 34157-83-0

Applications An antioxidant natural product which inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression. Used for clinical treatment for rheumatoid arthritis, was demonstrated to have antiangiogenic activity, and be inhibitory against mice tumor growth by a few recent studies. Celastrol also has been shown to have the power to kill tumor cells and can work as an anticarcinogen. Celastrol is also a leptin sensitizer with the potential to reduce weight in obesity (see W499200).
References Senger, D., et al.: Science, 219, 983 (1983), Folkman, J., et al.: Nature, 1, 27 (1995), He, W., et al.: Bioorg. Med. Chem. Lett., 8, 3659 (1998), Grosios, K., et al.: Inflamm. Res., 53, 133 (2004), Yang, H., et al.: Cancer Res., 66, 4758 (2006); AAPS Newsmagazine p. 17, July 2016; Chem. and Eng. News p. 6, Aug. 8, 2016

Formula: C₂₉H₃₈O₄

Color and Shape: Neat

Molecular weight: 450.61

Ref: TR-C249500

Celastrol

Controlled Product

CAS: 34157-83-0

HSP90 inhibitor; topoisomerase II inhibitor; anti-inflammatory; antioxidant

Formula: C₂₉H₃₈O₄

Purity: Min. 95%

Color and Shape: Red Powder

Molecular weight: 450.61 g/mol

Ref: 3D-FC19885