CAS 3416-05-5

3'-deoxythymidine

Description:

3'-Deoxythymidine, also known as dThd or thymidine without the 3'-hydroxyl group, is a nucleoside that plays a crucial role in the structure of DNA. It consists of a thymine base attached to a deoxyribose sugar. The absence of the hydroxyl group at the 3' position distinguishes it from regular thymidine, which has implications for its biological activity and utility in various applications. This compound is typically a white to off-white crystalline powder and is soluble in water and alcohol. 3'-Deoxythymidine is significant in molecular biology and biochemistry, particularly in studies involving DNA synthesis and repair, as well as in antiviral therapies, where it can act as a substrate for DNA polymerases. Its CAS number, 3416-05-5, is a unique identifier that facilitates its identification in chemical databases. Overall, 3'-deoxythymidine is an important compound in both research and therapeutic contexts, contributing to our understanding of nucleic acid chemistry and cellular processes.

Formula: C₁₀H₁₄N₂O₄

InChI: InChI=1/C10H14N2O4/c1-6-4-12(10(15)11-9(6)14)8-3-2-7(5-13)16-8/h4,7-8,13H,2-3,5H2,1H3,(H,11,14,15)/t7-,8+/m0/s1

Synonyms:

• 2',3'-Dideoxythymidine
• Dideoxythymidine
• Nsc 617596
• Thymidine, 3'-deoxy-
• 1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione

3'-Deoxythymidine

CAS: 3416-05-5

Formula: C₁₀H₁₄N₂O₄

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 226.23

Ref: 3B-D6100

3'-Deoxythymidine

CAS: 3416-05-5

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₁₀H₁₄N₂O₄

Molecular weight: 226.23

Ref: 02-J65765

Thymidine, 3'-deoxy-

CAS: 3416-05-5

Formula: C₁₀H₁₄N₂O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 226.2292

Ref: IN-DA00I6R2

2',3'-Dideoxythymidine

CAS: 3416-05-5

2',3'-Dideoxythymidine

Purity: 97%

Molecular weight: 226.23g/mol

Ref: 54-BID2038

2'',3''-Dideoxythymidine

CAS: 3416-05-5

Formula: C₁₀H₁₄N₂O₄

Molecular weight: 226.23

Ref: 7W-GN6842

3'-Deoxythymidine

CAS: 3416-05-5

3'-Deoxythymidine (3DT) is a nucleoside analog that has high resistance to HIV. It is an analogue of the human insulin-like growth factor-1 (IGF-1), which binds to the IGF-1 receptor and inhibits the binding of IGF-1 to its receptor, thereby inhibiting the growth of cells. 3DT has been shown to have a protective effect against radiation in mice, with an LD50 at a dose of 5.0 mg/kg for radiation exposure. 3DT also has antiviral activity against murine sarcoma virus, as well as other biological properties such as enzyme activities and disease activity. This drug may be used in future research on polymerase chain reactions (PCRs) and DNA sequencing, since it is chemically stable and can be easily synthesized.

Formula: C₁₀H₁₄N₂O₄

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 226.23 g/mol

Ref: 3D-ND06301

2,3-Dideoxythymidine (3-Deoxythymidine, ddT) extrapure, 98%

CAS: 3416-05-5

Formula: C₁₀H₁₄N₂O₄

Purity: min. 98 %

Color and Shape: White to pale yellow, Powder

Molecular weight: 226.23

Ref: SR-22328

1-((2R,5S)-5-(Hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

CAS: 3416-05-5

Formula: C₁₀H₁₄N₂O₄

Purity: 98%

Molecular weight: 226.232

Ref: 10-F211267

3′-deoxy Thymidine

CAS: 3416-05-5

d2T, a nucleoside analog of thymidine, exhibits antiviral activity by inhibiting HIV replication in infected human peripheral blood mononuclear cells (PBMCs; EC50 = 0.17 µM). Additionally, 3′-deoxy Thymidine at concentrations of 1, 3, 10, or 30 µM significantly decreases viral plaque formation in CV-1 cells infected with herpes simplex virus 1 (HSV-1).

Formula: C₁₀H₁₄N₂O₄

Color and Shape: Solid

Molecular weight: 226.232

Ref: TM-T84987