CAS 34221-41-5

(2E)-3-(4-hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one

Description:

The chemical substance known as (2E)-3-(4-hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one, with the CAS number 34221-41-5, is a type of chalcone, which is a class of compounds characterized by a specific structure featuring a phenyl group connected to an α,β-unsaturated carbonyl system. This compound exhibits notable antioxidant and anti-inflammatory properties, making it of interest in various fields, including medicinal chemistry and pharmacology. Its structure includes multiple hydroxyl groups, which contribute to its reactivity and potential biological activity. The presence of the methoxy group enhances its lipophilicity, potentially influencing its absorption and distribution in biological systems. Additionally, the compound may exhibit UV-absorbing properties due to its conjugated double bond system, which can be relevant in applications such as photoprotection. Overall, this substance is a valuable candidate for further research into its therapeutic potential and mechanisms of action in biological systems.

Formula: C₁₆H₁₄O₄

InChI: InChI=1/C16H14O4/c1-20-16-10-14(18)8-4-12(16)5-9-15(19)11-2-6-13(17)7-3-11/h2-10,17-18H,1H3/b9-5+

Synonyms:

• (E)-4,4'-Dihydroxy-2-methoxychalcone
• 2-propen-1-one, 3-(4-hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)-, (2E)-
• 34221-41-5
• Echinatin
• 4,4'-Dihydroxy-2-Methoxychalcone
• ECHINATIN(RG)(CALL)
• 4'-Dihydroxy-2-Methoxychalcone
• (E)-3-(4-Hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)-2-propen-1-one
• 4,4'-Dihydroxy-2-methoxy-trans-chalcone
• 3-(4-Hydroxy-2-Methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one
• Retrochalcone
• (E)-3-(4-hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one
• 4',4-DIHYDROXY-2-METHOXYCHALCONE

4,4'-Dihydroxy-2-methoxychalcone

CAS: 34221-41-5

Formula: C₁₆H₁₄O₄

Purity: 95%

Color and Shape: Solid

Molecular weight: 270.2800

Ref: IN-DA00BZA4

3-(4-Hydroxy-2-Methoxyphenyl)-1-(4-Hydroxyphenyl)Prop-2-En-1-One

CAS: 34221-41-5

3-(4-Hydroxy-2-Methoxyphenyl)-1-(4-Hydroxyphenyl)Prop-2-En-1-One

Purity: 95%

Molecular weight: 270.28g/mol

Ref: 54-OR1024119

Echinatin

CAS: 34221-41-5

Formula: C₁₆H₁₄O₄

Molecular weight: 270.28

Ref: 7W-GY2420

Echinatin

CAS: 34221-41-5

Echinatin

Purity: ≥95%

Molecular weight: 270.28g/mol

Ref: 54-BUP12201

Echinatin

CAS: 34221-41-5

Echinatin has significant antioxidant and anti-inflammary activities, it shows strong scavenging activity toward the ABTS + radical, it also inhibits the production of nitric oxide (NO), interleukin-6 (IL-6) and prostaglandin E2 (PGE2) in LPS-induced macrophage cells. Echinatin disturbs the mitochondrial energy transfer reactions and membrane permeability, at a low concentration cause deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria, inhibits DNP-ATPase activity while stimulating range latent ATPase activity.

Formula: C₁₆H₁₄O₄

Purity: 95%~99%

Molecular weight: 270.284

Ref: BP-BP0521

Echinatin

CAS: 34221-41-5

Echinatin (Retrochalcone) is a natural chalcone. Echinatin has hepatoprotective and anti-inflammatory effects. Cost effective and quality assured.

Formula: C₁₆H₁₄O₄

Purity: 97.13% - 99.61%

Color and Shape: Solid

Molecular weight: 270.28

Ref: TM-T3926

Echinatin (flavonoid)

CAS: 34221-41-5

Ketone phenol

Formula: C₁₆H₁₄O₄

Purity: ≥ 95.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 270.28

Ref: 5G-83847

Echinatin

CAS: 34221-41-5

Echinatin is a naturally occurring product classified as a chalcone, which is sourced primarily from the roots of the Echinacea species. Chalcones are aromatic ketones that are a key intermediate in the biosynthesis of flavonoids. Echinatin functions through multiple biochemical pathways, prominently inhibiting the production of pro-inflammatory mediators by targeting specific signaling cascades. This mode of action suggests its potential as a bioactive compound with significant anti-inflammatory and antioxidant properties.

Formula: C₁₆H₁₄O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 270.28 g/mol

Ref: 3D-FE73854

Echinatin

Controlled Product

CAS: 34221-41-5

Applications Echinatin is used as an anticancer agent inhibiting DNA topoisomerase IB and Tyrosyl-DNA phosphodiesterase 1 inhibitors.
References Zhang, H. et al.: Bioorg. Med. Chem., 28, 115527 (2020);

Formula: C₁₆H₁₄O₄

Color and Shape: Neat

Molecular weight: 270.28

Ref: TR-E378505