CAS 34233-69-7
:Clozapine N-oxide
Description:
Clozapine N-oxide is a chemical compound that serves as a metabolite of the antipsychotic medication clozapine. It is characterized by its unique structure, which includes a dibenzodiazepine core with an N-oxide functional group. This modification enhances its solubility and alters its pharmacological properties compared to clozapine. Clozapine N-oxide is primarily used in research settings, particularly in studies involving the activation of designer receptors exclusively activated by designer drugs (DREADDs). It exhibits selective binding to certain receptors, which allows researchers to manipulate neuronal activity in experimental models. The compound is typically administered in a controlled manner to investigate its effects on behavior and neurobiology. Clozapine N-oxide is known for its relatively low toxicity and favorable pharmacokinetic profile, making it a valuable tool in neuroscience research. However, as with any chemical substance, proper handling and safety precautions are essential due to its potential biological effects.
Formula:C18H19ClN4O
InChI:InChI=1S/C18H19ClN4O/c1-23(24)10-8-22(9-11-23)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
InChI key:InChIKey=OGUCZBIQSYYWEF-UHFFFAOYSA-N
SMILES:CN1(=O)CCN(C=2C=3C(NC=4C(N2)=CC(Cl)=CC4)=CC=CC3)CC1
Synonyms:- 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-, N-oxide
- 5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-methyl-4-oxido-1-piperazinyl)-
- 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine N-oxide
- 8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
- 8-chloro-11-(4-methylpiperazin-1-yl)-10H-dibenzo[b,e][1,4]diazepin-10-ol
- Vufb-12426
- Clozapine N-oxide
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Found 13 products.
Clozapine N-oxide, 99%
CAS:<p>This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci</p>Formula:C18H19ClN4OPurity:99%Molecular weight:342.83Clozapine N-oxide
CAS:Formula:C18H19ClN4OPurity:≥ 98.0% (dried basis)Color and Shape:Yellow to dark yellow powderMolecular weight:342.82Clozapine N-Oxide
CAS:Controlled ProductFormula:C18H19ClN4OColor and Shape:NeatMolecular weight:342.82Clozapine N-Oxide
CAS:<p>View and buy CLOZAPINE N-OXIDE from TargetMol.Clozapine N-oxide is a major metabolite of clozapine also known as DREADDs, technology to modulate synthetic receptors in vivo.Cited in 2 publications.</p>Formula:C18H19ClN4OPurity:98.43% - 99.94%Color and Shape:SolidMolecular weight:342.82Clozapine N-Oxide
CAS:Controlled Product<p>Impurity CLOZAPINE N-OXIDE IMPURITY<br>Applications Clozapine N-Oxide is a 5-HT2 antagonist. It is a major metabolite of clozapine (C587500) that can be monitored by HPLC.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Baldessarini, E., et al.: Neuropsychopharmacol., 9, 117 (1993); Lin, G., et al.: J. Pharm. Sci, 83, 1412 (1994); Roth, B.L., et al.: J. Pharmacol. Exp. Ther., 268, 1403 (1994)<br></p>Formula:C18H19ClN4OColor and Shape:Light Yellow To YellowMolecular weight:342.82Clozapine N-Oxide-d8
CAS:Controlled ProductFormula:C18H11D8ClN4OColor and Shape:Yellow To Dark YellowMolecular weight:350.87Clozapine N-oxide
CAS:<p>Activates muscarinic GPCR DREADDs, which are unaffected by the endogenous ligand acetycholamine of the parent receptor. Clozapine is metabolized to clozapine N oxide in the liver, mainly by CYP3A4. Has anti-seizure effects, when induced by chemoconvulsants pilocarpine and picrotoxin.</p>Formula:C18H19ClN4OPurity:Min. 99 Area-%Color and Shape:Yellow PowderMolecular weight:342.82 g/molClozapine N-Oxide
CAS:Formula:C18H19ClN4OPurity:>95.0%(T)(HPLC)Color and Shape:White to Yellow powder to crystalMolecular weight:342.83
