CAS 34233-69-7: Clozapine N-oxide

Description: Clozapine N-oxide is a chemical compound that serves as a metabolite of the antipsychotic medication clozapine. It is characterized by its unique structure, which includes a dibenzodiazepine core with an N-oxide functional group. This modification enhances its solubility and alters its pharmacological properties compared to clozapine. Clozapine N-oxide is primarily used in research settings, particularly in studies involving the activation of designer receptors exclusively activated by designer drugs (DREADDs). It exhibits selective binding to certain receptors, which allows researchers to manipulate neuronal activity in experimental models. The compound is typically administered in a controlled manner to investigate its effects on behavior and neurobiology. Clozapine N-oxide is known for its relatively low toxicity and favorable pharmacokinetic profile, making it a valuable tool in neuroscience research. However, as with any chemical substance, proper handling and safety precautions are essential due to its potential biological effects.

Formula: C₁₈H₁₉ClN₄O

InChI: InChI=1S/C18H19ClN4O/c1-23(24)10-8-22(9-11-23)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3

InChI key: InChIKey=OGUCZBIQSYYWEF-UHFFFAOYSA-N

SMILES: O=N1(C)CCN(C2=NC3=CC(Cl)=CC=C3NC=4C=CC=CC42)CC1

Synonyms:

• 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-, N-oxide
• 5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-methyl-4-oxido-1-piperazinyl)-
• 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine N-oxide
• 8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
• 8-chloro-11-(4-methylpiperazin-1-yl)-10H-dibenzo[b,e][1,4]diazepin-10-ol
• Vufb-12426
• Clozapine N-oxide

Clozapine N-oxide, 99%

CAS: 34233-69-7

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. …

• Formula: C₁₈H₁₉ClN₄O
• Purity: 99%
• Molecular weight: 342.83

Clozapine N-oxide

CAS: 34233-69-7

• Formula: C₁₈H₁₉ClN₄O
• Purity: ≥ 98.0% (dried basis)
• Color and Shape: Yellow to dark yellow powder
• Molecular weight: 342.82

Clozapine N-Oxide

CAS: 34233-69-7

• Formula: C₁₈H₁₉ClN₄O
• Color and Shape: Light Yellow To Yellow
• Molecular weight: 342.82

Clozapine N-Oxide-d8

CAS: 34233-69-7

• Formula: C₁₈H₁₁D₈ClN₄O
• Molecular weight: 350.88

Clozapine N-Oxide

CAS: 34233-69-7

• Formula: C₁₇H₁₆ClN₄O₂
• Molecular weight: 343.80

Clozapine N-Oxide

CAS: 34233-69-7

View and buy CLOZAPINE N-OXIDE from TargetMol.Clozapine N-oxide is a major metabolite of clozapine also …

• Formula: C₁₈H₁₉ClN₄O
• Purity: 98.43% - 99.94%
• Color and Shape: Solid
• Molecular weight: 342.82

Clozapine N-Oxide-d8

CAS: 34233-69-7

• Formula: C₁₈H₁₁D₈ClN₄O
• Color and Shape: Yellow To Dark Yellow
• Molecular weight: 350.87

Clozapine N-Oxide

CAS: 34233-69-7

Impurity CLOZAPINE N-OXIDE IMPURITY Applications Clozapine N-Oxide is a 5-HT2 antagonist. It is a major …

• Formula: C₁₈H₁₉ClN₄O
• Color and Shape: Light Yellow To Yellow
• Molecular weight: 342.82

Clozapine N-oxide

CAS: 34233-69-7

Activates muscarinic GPCR DREADDs, which are unaffected by the endogenous ligand acetycholamine of the parent …

• Formula: C₁₈H₁₉ClN₄O
• Purity: Min. 99 Area-%
• Color and Shape: Yellow Powder

Clozapine N-Oxide

CAS: 34233-69-7

• Formula: C₁₈H₁₉ClN₄O
• Purity: >95.0%(T)(HPLC)
• Color and Shape: White to Yellow powder to crystal
• Molecular weight: 342.83