CAS 342652-67-9

3-(1,1-Dimethylethyl)-7-(5-methyl-3-isoxazolyl)-2-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]pyrazolo[1,5-d][1,2,4]triazine

Description:

The chemical substance known as 3-(1,1-Dimethylethyl)-7-(5-methyl-3-isoxazolyl)-2-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]pyrazolo[1,5-d][1,2,4]triazine, with the CAS number 342652-67-9, is a complex organic compound characterized by its multi-ring structure and various functional groups. It features a pyrazolo[1,5-d][1,2,4]triazine core, which is a bicyclic compound known for its potential biological activity. The presence of isoxazole and triazole moieties suggests that this compound may exhibit interesting pharmacological properties, possibly acting as a bioactive agent in agricultural or medicinal chemistry. The tert-butyl group (1,1-dimethylethyl) contributes to its hydrophobic characteristics, while the methoxy group enhances solubility and reactivity. Overall, this compound's unique structural features may lead to specific interactions with biological targets, making it a subject of interest for further research in drug development or agrochemical applications.

Formula: C₁₇H₂₀N₈O₂

InChI: InChI=1S/C17H20N8O2/c1-10-6-11(23-27-10)15-21-19-7-12-14(17(2,3)4)16(22-25(12)15)26-8-13-18-9-20-24(13)5/h6-7,9H,8H2,1-5H3

InChI key: InChIKey=QYSYOGCIDRANAR-UHFFFAOYSA-N

SMILES: C(C)(C)(C)C1=C2N(C(=NN=C2)C3=NOC(C)=C3)N=C1OCC=4N(C)N=CN4

Synonyms:

• Pyrazolo[1,5-d][1,2,4]triazine, 3-(1,1-dimethylethyl)-7-(5-methyl-3-isoxazolyl)-2-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-
• 3-(1,1-Dimethylethyl)-7-(5-methyl-3-isoxazolyl)-2-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]pyrazolo[1,5-d][1,2,4]triazine
• MRK 016

MRK-016

CAS: 342652-67-9

MRK-016

Purity: ≥98%

Molecular weight: 368.39g/mol

Ref: 54-BUP21075

MRK-016

CAS: 342652-67-9

MRK-016 is a selective GABAA α5 receptor inverse agonist/ negative allosteric modulator, orally available and penetrating the BBB. MRK-016 is antidepressant.

Formula: C₁₇H₂₀N₈O₂

Purity: 99.76%

Color and Shape: Solid

Molecular weight: 368.39

Ref: TM-T12105

MRK 016

CAS: 342652-67-9

MRK 016 is an antidepressant drug that acts by potentiating the effect of serotonin and norepinephrine. It has been shown to be effective in treating depression in animals by increasing the production of growth factor and chloride, which are necessary for neuronal function. MRK 016 is a racemic mixture of two enantiomers, with the S-enantiomer being more potent than the R-enantiomer. MRK 016 binds to the benzodiazepine binding site on GABA receptors at nanomolar concentrations, but does not act as an antagonist or agonist. This drug also binds to alpha-1 adrenergic receptors with high affinity, inhibiting receptor activity and reducing anxiety. The pharmacokinetic properties of MRK 016 have been studied in both rats and wild-type mice. In rats, MRK 016 has a short plasma half-life and a low volume of distribution. In mice, this drug has a longer plasma half-life and higher volume of

Formula: C₁₇H₂₀N₈O₂

Purity: Min. 95%

Molecular weight: 368.39 g/mol

Ref: 3D-SNA65267