CAS 34273-10-4

Saralasin

Description:

Saralasin is a synthetic peptide that serves as an angiotensin II antagonist, primarily used in research to study the renin-angiotensin system and its role in cardiovascular physiology. It is a modified form of the natural peptide angiotensin II, with alterations that enhance its binding affinity to angiotensin receptors while inhibiting their activity. Saralasin is characterized by its ability to mimic the effects of angiotensin II, leading to vasodilation and a decrease in blood pressure, making it a valuable tool in pharmacological studies. The compound is typically administered in a controlled laboratory setting, and its effects can vary based on dosage and the physiological context. Saralasin's structure includes specific amino acid substitutions that contribute to its antagonistic properties, allowing researchers to explore the mechanisms of hypertension and related disorders. As a research chemical, it is not commonly used in clinical practice but remains significant in the study of cardiovascular diseases and the development of antihypertensive therapies.

Formula: C₄₂H₆₅N₁₃O₁₀

InChI: InChI=1/C42H65N13O10/c1-22(2)33(53-35(58)28(50-32(57)20-45-6)9-7-15-47-42(43)44)38(61)51-29(17-25-11-13-27(56)14-12-25)36(59)54-34(23(3)4)39(62)52-30(18-26-19-46-21-48-26)40(63)55-16-8-10-31(55)37(60)49-24(5)41(64)65/h11-14,19,21-24,28-31,33-34,45,56H,7-10,15-18,20H2,1-6H3,(H,46,48)(H,49,60)(H,50,57)(H,51,61)(H,52,62)(H,53,58)(H,54,59)(H,64,65)(H4,43,44,47)/t24-,28-,29-,30-,31-,33-,34-/m0/s1

SMILES: CC(C)[C@@H](C(=N[C@@H](Cc1ccc(cc1)O)C(=N[C@@H](C(C)C)C(=N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=N[C@@H](C)C(=O)O)O)O)O)O)N=C([C@H](CCCNC(=N)N)N=C(CNC)O)O

Synonyms:

• (1-(N-Methylglycin) 5-L-valin, 8-L-alanin)angiotensin II
• N-(1-(N-(N-(N-(N-(N2-(N-methylglycly)-L-arginyl)-L-valyl)-L-tyrosyl)-L-valyl)-L-histidyl)-L-prolyl)-L-alanine
• Saralasina
• Saralasina [INN-Spanish]
• Saralasine
• Saralasine [INN-French]
• Saralasinum
• Saralasinum [INN-Latin]
• Unii-H2Afv2He66
• Angiotensin II, 1-(N-methylglycine)-5-L-valine-8-L-alanine-
• N-methylglycyl-N~5~-(diaminomethylidene)ornithylvalyltyrosylvalylhistidylprolylalanine

Saralasin

CAS: 34273-10-4

Competitive non-selective angiotensin II antagonist.

Formula: C₄₂H₆₅N₁₃O₁₀

Purity: 98%

Color and Shape: Powder

Molecular weight: 912

Ref: TM-TP1929

Saralasin TFA Salt

Controlled Product

CAS: 34273-10-4

Formula: C₄₂H₆₅N₁₃O₁₀·x(C₂HF₃O₂)

Color and Shape: White To Off-White

Molecular weight: 1026.07

Ref: TR-S142630

Saralasin

Controlled Product

CAS: 34273-10-4

Applications Saralasin are angiotensin II receptor agonists.
References Guimond, M., et al.: J. Med. Chem. Lett., 5, 1129 (2014)

Formula: C₄₂H₆₅N₁₃O₁₀

Color and Shape: Neat

Molecular weight: 912.047

Ref: TR-S142510

[Sar1,Val5,Ala8]-Angiotensin II

CAS: 34273-10-4

Sar1,Val5,Ala8]-Angiotensin II is a peptide with the amino acid sequence of [Sar1,Val5,Ala8]-Angiotensin II. The peptide is a research tool that can be used to study the effects of angiotensin on ion channels and receptor interactions. Sar1,Val5,Ala8]-Angiotensin II has also been shown to inhibit the binding of angiotensin I (AI) to its receptors. Sar1,Val5,Ala8]-Angiotensin II binds to the AT1 receptor and blocks its activation by AI. Sar1,Val5,Ala8]-Angiotensin II is a potent inhibitor of protein interactions and may have applications in pharmacology and cell biology.

Formula: C₄₂H₆₅N₁₃O₁₀

Purity: Min. 95%

Molecular weight: 912.05 g/mol

Ref: 3D-PAN-4071-V

(Sar 1,Val5,Ala8)-Angiotensin II trifluoroacetate salt

CAS: 34273-10-4

Angiotensin II is a peptide hormone that is also known as angiotensin II trifluoroacetate salt. It has been shown to have cardioprotective effects in vivo and in vitro models. Angiotensin II has been shown to induce follicular growth, inhibit atherosclerotic lesion formation, and improve cardiac function. Angiotensin II can be used to treat patients with congestive heart failure or cardiovascular disease due to its ability to increase blood pressure and the rate of cardiac contractions. The drug also reduces systolic pressure by acting on receptors in the kidneys and vasculature, which are involved in the renin-angiotensin system.

Formula: C₄₂H₆₅N₁₃O₁₀•C₂HF₃O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 1,026.07 g/mol

Ref: 3D-FS108389