CAS 342790-22-1

Hepcidin-22 (human)

Description:

Hepcidin-22 is a peptide that plays a crucial role in iron metabolism and homeostasis in humans. It is a fragment of the larger hepcidin protein, consisting of 22 amino acids. This peptide is primarily produced by the liver and functions as a regulatory hormone that controls the absorption of iron from the diet and the release of iron from macrophages and liver stores. Hepcidin-22 exerts its effects by binding to the iron transporter ferroportin, leading to its internalization and degradation, thereby reducing iron availability in the bloodstream. This mechanism is particularly important in conditions of iron overload or inflammation, where hepcidin levels are elevated to prevent excess iron accumulation. The peptide is also involved in various physiological processes, including immune response and erythropoiesis. Dysregulation of hepcidin levels can lead to disorders such as anemia of chronic disease or hereditary hemochromatosis. Overall, Hepcidin-22 is a vital component in maintaining iron balance and overall metabolic health.

Formula: C₉₉H₁₅₁N₂₉O₂₅S₉

Synonyms:

• Hepcidin-22 (human)

Hepcidin-22 (human)

CAS: 342790-22-1

An inactive degradation product of hepcidin-25 found in human urine.

Formula: C₉₉H₁₅₁N₂₉O₂₅S₉

Purity: > 95%

Color and Shape: White Powder

Molecular weight: 2436.06

Ref: 01-4065376

Hepcidin-22 (Human)

CAS: 342790-22-1

Hepcidin product containing the disulfide Bonds: Cys4-Cys20, Cys7-Cys10, Cys8-Cys16, and Cys11-Cys19 and available in the trifluoroacetate salt form. Hepcidin-22 is a variant of the peptide hormone hepcidin-25, which plays an important role in the regulation of iron metabolism in the body. Hepcidin is produced by the liver and is secreted into the bloodstream.
Hepcidin binds to ferroportin, a protein that facilitates the export of iron from cells into the bloodstream, and to inhibit its activity.
The biological significance of hepcidin-22 is still being studied, but it may play a role in the regulation of iron metabolism in certain situations, such as inflammation or certain disease states. Both hepcidin-22 and hepcidin-25 are targets for the development of treatments for iron-related disorders, such as anemia of chronic disease and hemochromatosis.

Formula: C₉₉H₁₅₁N₂₉O₂₅S₉

Purity: Min. 95%

Molecular weight: 2,436.06 g/mol

Ref: 3D-PLP-3776-PI

Hepcidin-22 (human) trifluoroacetate salt

CAS: 342790-22-1

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Formula: C₉₉H₁₅₁N₂₉O₂₅S₉

Purity: Min. 95%

Molecular weight: 2,436.03 g/mol

Ref: 3D-FH110067