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CAS 342896-25-7

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Ent-Amyloid Beta-Protein (1-42)

Description:
Ent-Amyloid Beta-Protein (1-42), with the CAS number 342896-25-7, is a peptide that plays a significant role in the pathophysiology of Alzheimer's disease. This protein is a variant of the amyloid beta peptide, which is derived from the amyloid precursor protein (APP) through enzymatic cleavage. The "1-42" designation indicates that this peptide consists of 42 amino acids, and it is known for its propensity to aggregate into oligomers and fibrils, forming amyloid plaques that are characteristic of Alzheimer's disease. The ent-configuration refers to a specific stereochemical arrangement of the peptide, which can influence its biological activity and aggregation properties. In terms of solubility, amyloid beta peptides can be soluble in aqueous solutions at low concentrations but may precipitate at higher concentrations. The study of Ent-Amyloid Beta-Protein (1-42) is crucial for understanding its role in neurodegeneration and for developing potential therapeutic strategies aimed at mitigating its toxic effects in the brain.
Synonyms:
  • H-D-Asp-D-Ala-D-Glu-D-Phe-D-Arg-D-His-D-Asp-D-Ser-Gly-D-Tyr-D-Glu-D-Val-D-His-D-His-D-Gln-D-Lys-D-Leu-D-Val-D-Phe-D-Phe-D-Ala-D-Glu-D-Asp-D-Val-Gly-D-Ser-D-Asn-D-Lys-Gly-D-Ala-D-Ile-D-Ile-Gly-D-Leu-D-Met-D-Val-Gly-Gly-D-Val-D-Val-D-Ile-D-Ala-Oh
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