CAS 343-65-7

Kynurenine

Description:

Kynurenine is an endogenous metabolite of the amino acid tryptophan, playing a significant role in various biological processes. It is primarily involved in the kynurenine pathway, which is crucial for the metabolism of tryptophan and the production of several neuroactive compounds. Kynurenine is characterized by its structure, which includes an indole ring and a side chain containing a carboxylic acid and an amine group. This compound exhibits a range of biological activities, including neuroprotective and neurotoxic effects, depending on its concentration and the presence of other metabolites in the kynurenine pathway. Kynurenine is also implicated in immune response regulation and has been studied for its potential role in various neurological disorders, including depression and neurodegenerative diseases. Its solubility in water and various organic solvents allows for diverse applications in biochemical research. Additionally, kynurenine can be measured in biological samples, making it a valuable biomarker for assessing metabolic and pathological conditions.

Formula: C₁₀H₁₂N₂O₃

InChI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)

InChI key: InChIKey=YGPSJZOEDVAXAB-UHFFFAOYSA-N

SMILES: C(CC(C(O)=O)N)(=O)C1=C(N)C=CC=C1

Synonyms:

• 2-Amino-4-(2-Aminophenyl)-4-Oxobutanoic Acid
• 2-Amino-4-(2-aminophenyl)-4-oxobutanoicacid
• 3-Anthraniloyl-<span class="text-smallcaps">D</smallcap><smallcap>L</span>-alanine
• 3-Anthraniloylalanine
• <span class="text-smallcaps">DL</span>-Kynurenine
• Alanine, 3-anthraniloyl-
• Benzenebutanoic acid, α,2-diamino-γ-oxo-
• Beta-Anthraniloyl-Alpha-Alanine
• Dl-Kynurenine Free Base
• Kynurenin
• Kynurenine

DL-Kynurenine

CAS: 343-65-7

Formula: C₁₀H₁₂N₂O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 208.2139

Ref: IN-DA00BYZG

Kynurenine

CAS: 343-65-7

Formula: C₁₀H₁₂N₂O₃

Molecular weight: 208.22

Ref: 4Z-K-008003

2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid

CAS: 343-65-7

2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid

Purity: ≥98%

Molecular weight: 208.21g/mol

Ref: 54-BUP14242

DL-Kynurenine

CAS: 343-65-7

Ref: 7W-GM2236

DL-Kynurenine-d7 (2,3,3-d3 ;ring-d4)

CAS: 343-65-7

Purity: 99 atom % D

Molecular weight: 215.26

Ref: 3U-D8212

2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid

CAS: 343-65-7

2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid: a vasodilator, immunomodulator, neuromodulator, niacin precursor, and potential cancer biomarker.

Formula: C₁₀H₁₂N₂O₃

Purity: 99.04% - 99.66%

Color and Shape: Solid

Molecular weight: 208.21

Ref: TM-T3011

rac Kynurenine

Controlled Product

CAS: 343-65-7

Applications A tryptophan metabolite, is a precursor of kynurenic acid, which is an antagonist of N-methyl-aspartate receptor. An amino acid produced in the body from tryptophan.
References Swartz, K., et al.: J. Neurosci., 10, 2965 (1990), Hasegawa, H., et al.: Anal. Bioanal. Chem., 377, 886 (2003), Tsai, Y., et al.: Anal. Biochem., 319, 34 (2003), Mitsuhashi, S., et al.: Anal. Chim. Acta, 584, 315 (2007),

Formula: C₁₀H₁₂N₂O₃

Color and Shape: Neat

Molecular weight: 208.21

Ref: TR-K661000

rac Kynurenine-d4 Trifluoroacetic Acid Salt (Major)

Controlled Product

CAS: 343-65-7

Stability Hygroscopic
Applications rac Kynurenine-d4 Trifluoroacetic Acid Salt is the isotope labelled analog of rac Kynurenine (K661000) which is a tryptophan metabolite.
References Swartz, K., et al.: J. Neurosci., 10, 2965 (1990), Hasegawa, H., et al.: Anal. Bioanal. Chem., 377, 886 (2003), Tsai, Y., et al.: Anal. Biochem., 319, 34 (2003), Mitsuhashi, S., et al.: Anal. Chim. Acta, 584, 315 (2007),

Formula: C₁₀H₈D₄N₂O₃•x(C₂HF₃O₂)

Color and Shape: Neat

Molecular weight: 212.2411402

Ref: TR-K661003

DL-Kynurenine, free base

CAS: 343-65-7

DL-Kynurenine, free base is an amino acid that is a product of the normal catabolic pathway for tryptophan. It is also present in some foods and may be produced endogenously from tryptophan or kynurenine. DL-Kynurenine is used as a polymerase chain reaction (PCR) substrate to detect enterovirus RNA and has been shown to be effective against bowel disease in vitro. DL-Kynurenine has been studied as a potential pharmacological agent for the treatment of inflammatory diseases such as rheumatoid arthritis, Crohn's disease, ulcerative colitis, and psoriasis. DL-Kynurenine binds to toll-like receptor 4 (TLR4) and inhibits picolinic acid production by macrophages. This leads to decreased matrix metalloproteinase activity and energy metabolism, which may have a protective effect on neuronal death by reducing oxidative stress.

Formula: C₁₀H₁₂N₂O₃

Purity: Min. 95%

Molecular weight: 208.20 g/mol

Ref: 3D-FK172296

DL-Kynurenine, free base

CAS: 343-65-7

DL-Kynurenine is a versatile building block, useful in the synthesis of complex compounds. The compound has been used as a reagent, and as a speciality chemical with high quality. DL-Kynurenine can be used as a starting material for the synthesis of other chemicals, such as pharmaceuticals or pesticides. It can also be used as an intermediate to produce drugs that are useful for the treatment of Alzheimer's disease, Huntington's disease, Parkinson's disease and schizophrenia. DL-Kynurenine is also an effective scaffold for drug design.

Formula: C₁₀H₁₂N₂O₃

Purity: Min. 95 Area-%

Molecular weight: 208.22 g/mol

Ref: 3D-K-9000

2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid

CAS: 343-65-7

Formula: C₁₀H₁₂N₂O₃

Purity: 98%

Molecular weight: 208.217

Ref: 10-F223134