CAS 343268-91-7

Orexin A (17-33)

CAS: 343268-91-7

Orexin A (17-33) acts as selective OX1 antagonist. Truncation studies have led to OXA (17-33) as the shortest active peptide known to date with a 23-fold selectivity for OX1 over OX2. The native orexins A and B do not show distinct receptor selectivity. Both OX receptors are involved in energy homeostasis and the sleep/wake cycle, hence selective as well as dual antagonists are required for research.

Formula: C₇₉H₁₂₅N₂₃O₂₂

Purity: >97%

Molecular weight: 1749.0

Ref: 01-4092130

OXA(17-33)

CAS: 343268-91-7

Potent and selective peptide orexin OX1 receptor agonist (EC50 values are 8.29 and 187 nM for OX1 and OX2 receptors respectively). Truncated form of orexin A.

Formula: C₇₉H₁₂₅N₂₃O₂₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 1749

Ref: TM-TP1973

Orexin-A (Human, 17-33)

CAS: 343268-91-7

Orexin-A (Human, 17-33) is a neuropeptide also known as hypocretin-1 and this product is available as a 0.1 mg vial. Orexin-A is primarily produced by a group of neurons located in the lateral hypothalamus of the brain, known as the orexinergic neurons.
Orexin-A is involved in regulating a variety of physiological functions, including the sleep-wake cycle, appetite, energy metabolism, and reward pathways. It acts as an agonist for two G protein-coupled receptors, known as orexin receptor 1 and orexin receptor 2.
Studies have shown that disruption of orexin signaling can lead to sleep disorders, obesity, and other metabolic disorders. Orexin-A has also been studied for its potential as a therapeutic target for the treatment of these disorders.

Formula: C₇₉H₁₂₅N₂₃O₂₂

Purity: Min. 95%

Molecular weight: 1,749 g/mol

Ref: 3D-POR-4482-S

Orexin A (17-33) trifluoroacetate salt

CAS: 343268-91-7

Orexin A (17-33) trifluoroacetate salt H-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu is a peptide fragment that belongs to the orexin family. It is a potent antagonist of the G protein coupled receptors, which are responsible for mediating the effects of endogenous and exogenous ligands. Orexin A (17-33) trifluoroacetate salt H has been shown to have cytosolic interactions with calcium ions, regulating their concentration in the cytosol. It also affects choline levels and increases intracellular calcium concentrations. The peptide also potentiates responses to cocaine and other drugs that target GPCRs. This drug has been shown to be active against xestospongin, an antibiotic that inhibits protein synthesis

Formula: C₇₉H₁₂₅N₂₃O₂₂

Purity: Min. 95%

Molecular weight: 1,748.98 g/mol

Ref: 3D-FO110143