CAS 343306-71-8

Sugammadex

Description:

Sugammadex is a synthetic cyclodextrin derivative primarily used as a neuromuscular blocking agent reversal agent in anesthesia. It functions by encapsulating and inactivating certain neuromuscular blockers, particularly rocuronium and vecuronium, thereby facilitating rapid recovery of muscle function after surgery. Sugammadex is characterized by its unique structure, which allows it to form stable complexes with these drugs, effectively reducing their free concentration in the bloodstream. This property leads to a quick reversal of neuromuscular blockade, making it a valuable tool in clinical settings. The substance is water-soluble and has a relatively low toxicity profile, which contributes to its safety in medical applications. Additionally, Sugammadex is administered intravenously and is known for its rapid onset of action, typically within minutes. Its use has transformed practices in anesthesia, allowing for more controlled and efficient recovery from muscle paralysis during surgical procedures.

Formula: C₇₂H₁₁₂O₄₈S₈

InChI: InChI=1S/C72H112O48S8/c73-33(74)1-9-121-17-25-57-41(89)49(97)65(105-25)114-58-26(18-122-10-2-34(75)76)107-67(51(99)43(58)91)116-60-28(20-124-12-4-36(79)80)109-69(53(101)45(60)93)118-62-30(22-126-14-6-38(83)84)111-71(55(103)47(62)95)120-64-32(24-128-16-8-40(87)88)112-72(56(104)48(64)96)119-63-31(23-127-15-7-39(85)86)110-70(54(102)46(63)94)117-61-29(21-125-13-5-37(81)82)108-68(52(100)44(61)92)115-59-27(19-123-11-3-35(77)78)106-66(113-57)50(98)42(59)90/h25-32,41-72,89-104H,1-24H2,(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,83,84)(H,85,86)(H,87,88)/t25-,26-,27-,28-,29-,30-,31-,32-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55?,56?,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-/m1/s1

InChI key: InChIKey=WHRODDIHRRDWEW-VBAJLPTGSA-N

SMILES: C(SCCC(O)=O)[C@@H]1[C@]2(O[C@]3(O[C@H](CSCCC(O)=O)[C@]([C@H](O)[C@H]3O)(O[C@]4(O[C@H](CSCCC(O)=O)[C@]([C@H](O)[C@H]4O)(O[C@]5(O[C@H](CSCCC(O)=O)[C@]([C@H](O)[C@H]5O)(O[C@]6(O[C@H](CSCCC(O)=O)[C@@](O[C@]7(O[C@H](CSCCC(O)=O)[C@@](O[C@]8(O[C@H](CSCCC(O)=O)[C@@](O[C@]9(O[C@H](CSCCC(O)=O)[C@@](O[C@@](O1)([C@H](O)[C@H]2O)[H])([C@H](O)C9O)[H])[H])([C@H](O)C8O)[H])[H])([C@H](O)[C@H]7O)[H])[H])([C@H](O)[C@H]6O)[H])[H])[H])[H])[H])[H])[H])[H])[H]

Synonyms:

• 6A,6B,6C,6D,6E,6F,6G,6H-Octakis-S-(2-carboxyethyl)-6A,6B,6C,6D,6E,6F,6G,6H-octathio-γ-cyclodextrin
• Sugammadex acid
• Bridion
• Sugammadex
• γ-Cyclodextrin, 6A,6B,6C,6D,6E,6F,6G,6H-octakis-S-(2-carboxyethyl)-6A,6B,6C,6D,6E,6F,6G,6H-octathio-

g-Cyclodextrin,6A,6B,6C,6D,6E,6F,6G,6H-octakis-S-(2-carboxyethyl)-6A,6B,6C,6D,6E,6F,6G,6H-octathio-

CAS: 343306-71-8

Formula: C₇₂H₁₁₂O₄₈S₈

Purity: 98%

Color and Shape: Solid

Molecular weight: 2002.1509

Ref: IN-DA00CKQ6

Sugammadex sodium salt

CAS: 343306-71-8

Formula: C₇₂H₁₀₄O₄₈S₈·8Na

Purity: ≥ 98.0% (100.0 - impurities)

Color and Shape: White to off-white powder

Molecular weight: 2178.01

Ref: 7W-GK8971

Sugammadex

CAS: 343306-71-8

Sugammadex reverses rocuronium-induced neuromuscular blockade, first selective relaxant binding agent (SRBA), modified γ-cyclodextrin.

Formula: C₇₂H₁₁₂O₄₈S₈

Color and Shape: Solid

Molecular weight: 2002.15

Ref: TM-T5326L

6A,6B,6C,6D,6E,6F,6G,6H-octakis-S-(2-carboxyethyl)-6A,6B,6C,6D,6E,6F,6G,6H-octathio-γ-Cyclodextrin

Controlled Product

CAS: 343306-71-8

Applications 6A,6B,6C,6D,6E,6F,6G,6H-octakis-S-(2-carboxyethyl)-6A,6B,6C,6D,6E,6F,6G,6H-octathio-γ-Cyclodextrin, also known as Sugammadex, is used to reverse postoperative residual neuromuscular blockade.
References Liu, G.; et al.: Sci. Rep., 7, 1 (2017).

Formula: C₇₂H₁₁₂O₄₈S₈

Color and Shape: Neat

Molecular weight: 2002.15

Ref: TR-C246000

Sugammadex

CAS: 343306-71-8

Sugammadex is a modified gamma-cyclodextrin specifically designed to reverse the effects of steroidal non-depolarizing neuromuscular blocking drugs, particularly rocuronium and vecuronium. In anesthesiology, it offers a novel approach to neuromuscular blockade reversal by directly encapsulating and inactivating these muscle relaxants. Sugammadex forms tight 1:1 complexes with free plasma rocuronium or vecuronium molecules, rapidly reducing their concentration at the neuromuscular junction. This mechanism allows for fast and predictable reversal of neuromuscular blockade, even from deep levels, without the need for anticholinesterases or antimuscarinic agents. Sugammadex has also shown promise in special populations, including pregnancy, pediatrics, and patients with renal or hepatic impairment.

Formula: C₇₂H₁₁₂O₄₈S₈

Purity: Min. 95%

Molecular weight: 2,002.16 g/mol

Ref: 3D-OS165431