CAS 34336-99-7

Ac-Phe-Gly-pNA

Description:

Ac-Phe-Gly-pNA, also known as N-acetylphenylglycine p-nitroanilide, is a synthetic peptide derivative characterized by its specific amino acid sequence and functional groups. The "Ac" denotes an acetyl group, which enhances the stability and solubility of the compound. The presence of phenylalanine (Phe) and glycine (Gly) contributes to its structural properties, while the p-nitroanilide (pNA) moiety serves as a chromogenic substrate, making it useful in various biochemical assays, particularly in enzyme activity studies. This compound is often employed in research settings to measure proteolytic activity, as it can be cleaved by specific enzymes, releasing a colored product that can be quantified spectrophotometrically. Ac-Phe-Gly-pNA is typically soluble in organic solvents and water, and its stability can be influenced by pH and temperature. As with many synthetic peptides, it is essential to handle this compound with care, following appropriate safety protocols, as it may exhibit biological activity or toxicity depending on the context of its use.

Formula: C₁₉H₂₀N₄O₅

InChI: InChI=1/C19H20N4O5/c1-13(24)21-17(11-14-5-3-2-4-6-14)19(26)22-18(25)12-20-15-7-9-16(10-8-15)23(27)28/h2-10,17,20H,11-12H2,1H3,(H,21,24)(H,22,25,26)/t17-/m0/s1

Synonyms:

• N-Acetylphenylalanylglycine 4-nitroanilide
• Nacphe-gly-4-NA
• Glycinamide, N-acetyl-L-phenylalanyl-N-(4-nitrophenyl)-
• Nalpha-acetyl-N-{[(4-nitrophenyl)amino]acetyl}-L-phenylalaninamide

Ac-Phe-Gly-pNA

CAS: 34336-99-7

Chromogenic papain substrate.

Formula: C₁₉H₂₀N₄O₅

Purity: > 99%

Color and Shape: Whitish Powder

Molecular weight: 384.39

Ref: 01-4005053

Ac-Phe-Gly-pNA

CAS: 34336-99-7

Ac-Phe-Gly-pNA is the chymotrypsin specific substrate [1] .

Formula: C₁₉H₂₀N₄O₅

Color and Shape: Solid

Molecular weight: 384.39

Ref: TM-T74692

Ac-Phe-Gly-pNA

CAS: 34336-99-7

Ac-Phe-Gly-pNA is a peptidyl prodrug that has been shown to have proteolytic activity against cells of the malignant phenotype. Ac-Phe-Gly-pNA is converted to an active form by serine proteases, which are found on the surface of trophozoites and in cancerous cells. The sequence of Ac-Phe-Gly-pNA is homologous with a protein found in Giardia lamblia, and it has been shown to be active against this parasite. Ac-Phe-Gly-pNA can also be detected with fluorogenic substrates and aminopeptidase activity.

Formula: C₁₉H₂₀N₄O₅

Purity: Min. 95%

Molecular weight: 384.39 g/mol

Ref: 3D-FA110700