CAS 3434-88-6

Estradiol, diacetate

Description:

Estradiol diacetate is a synthetic derivative of estradiol, a naturally occurring estrogen hormone. It is characterized by the presence of two acetyl groups attached to the hydroxyl groups of the estradiol molecule, which enhances its lipophilicity and stability. This modification allows for improved absorption and prolonged action in the body. Estradiol diacetate is typically a white to off-white crystalline powder and is soluble in organic solvents such as ethanol and acetone, but has limited solubility in water. It is primarily used in hormone replacement therapy and in various pharmaceutical formulations to treat conditions related to estrogen deficiency. The compound exhibits estrogenic activity, influencing various physiological processes, including the regulation of the menstrual cycle and maintenance of secondary sexual characteristics. As with other estrogens, it may have side effects and contraindications, necessitating careful consideration in therapeutic applications. Proper handling and storage conditions are essential to maintain its stability and efficacy.

Formula: C₂₂H₂₈O₄

InChI: InChI=1S/C22H28O4/c1-13(23)25-16-5-7-17-15(12-16)4-6-19-18(17)10-11-22(3)20(19)8-9-21(22)26-14(2)24/h5,7,12,18-21H,4,6,8-11H2,1-3H3/t18-,19-,20+,21+,22+/m1/s1

InChI key: InChIKey=VQHQLBARMFAKSV-AANPDWTMSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@](C=4C(CC3)=CC(OC(C)=O)=CC4)(CC1)[H])[H])(CC[C@@H]2OC(C)=O)[H]

Synonyms:

• (17Beta)-Estra-1,3,5(10)-Triene-3,17-Diyl Diacetate
• 17beta-Estradiol diacetate
• 17β-Estradiol diacetate
• 3,17beta-Diacetoxyestra-1,3,5(10)-triene
• 3,17β-Diacetoxyestra-1,3,5(10)-triene
• Estra-1,3,5(10)-Triene-3,17-Diyl Diacetate
• Estra-1,3,5(10)-triene-3,17-diol (17beta)-, diacetate (9CI)
• Estra-1,3,5(10)-triene-3,17-diol (17β)-, 3,17-diacetate
• Estra-1,3,5(10)-triene-3,17-diol (17β)-, diacetate
• Estra-1,3,5(10)-triene-3,17beta-diol diacetate
• Estra-1,3,5(10)-triene-3,17β-diol diacetate
• Estradiol, diacetate
• Estradiol, diacetate (8CI)
• Estradiol-3,17-diacetate
• Estradiol-3,17beta-diacetate
• Estradiol-3,17β-diacetate
• Nsc 106559

Estradiol Impurity 20

CAS: 3434-88-6

Formula: C₂₂H₂₈O₄

Molecular weight: 356.46

Ref: 4Z-E-09111

17-β-Estradiol 3,17-diacetate

Controlled Product

CAS: 3434-88-6

Formula: C₂₂H₂₈O₄

Color and Shape: Neat

Molecular weight: 356.46

Ref: 04-C13213130

Estradiol Diacetate

Controlled Product

CAS: 3434-88-6

Formula: C₂₂H₂₈O₄

Color and Shape: Neat

Molecular weight: 356.46

Ref: 86-MM0300.12

17β-Estradiol diacetate

CAS: 3434-88-6

17b-Estradiol diacetate is a molecule that belongs to the group of fatty acid esters. It can be synthesized from 17β-estradiol and acetyl chloride in the presence of a base. The carbonyl group in this molecule has been shown to react with the hydroxyl group of serine residues on human liver microsomes and ovary cytosol, but not on human serum or human liver microsomes. 17b-Estradiol diacetate is also an analytical method for determining the concentration of estradiol in human serum and human liver samples. 17β-Estradiol diacetate is activated by enzymes, which causes its uptake by cells.

Formula: C₂₂H₂₈O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 356.46 g/mol

Ref: 3D-FE22830

17b-Estradiol Diacetate

Controlled Product

CAS: 3434-88-6

Applications Estradiol (E888000) derivative. An estrogen.
References Zhao, L., et al.: J. Med. Chem., et al.: 50, 4471 (2007),

Formula: C₂₂H₂₈O₄

Color and Shape: Neat

Molecular weight: 356.46

Ref: TR-E888045

β-Estradiol 3,17-diacetate

CAS: 3434-88-6

Formula: C₂₂H₂₈O₄

Molecular weight: 356.5

Ref: ST-EA-CP-E3005