CAS 343630-41-1

Urea,N-[4-bromo-2-(1H-tetrazol-5-yl)phenyl]-N'-[3-(trifluoromethyl)phenyl]-

Description:

Urea, N-[4-bromo-2-(1H-tetrazol-5-yl)phenyl]-N'-[3-(trifluoromethyl)phenyl]- is a synthetic organic compound characterized by its urea functional group, which is central to its structure. This compound features a complex arrangement that includes a brominated phenyl ring and a trifluoromethyl-substituted phenyl moiety, contributing to its unique chemical properties. The presence of the tetrazole ring enhances its potential biological activity, making it of interest in pharmaceutical research. The trifluoromethyl group is known for imparting lipophilicity and influencing the compound's interaction with biological targets. This compound is typically solid at room temperature and may exhibit moderate solubility in organic solvents. Its molecular structure suggests potential applications in medicinal chemistry, particularly in the development of new therapeutic agents. As with many halogenated compounds, it is essential to consider its environmental impact and toxicity profile during handling and application. Overall, this compound exemplifies the complexity and diversity of modern synthetic organic chemistry.

Formula: C₁₅H₁₀BrF₃N₆O

NS3623

CAS: 343630-41-1

NS3623 is an activator of human ether-a-go-go-related gene potassium channels.

Formula: C₁₅H₁₀BrF₃N₆O

Purity: 97.06%

Color and Shape: Solid

Molecular weight: 427.18

Ref: TM-T16347

NS 3623

CAS: 343630-41-1

Formula: C₁₅H₁₀BrF₃N₆O

Purity: %

Color and Shape: Solid

Molecular weight: 427.1787

Ref: IN-DA00C9TN

NS3623

CAS: 343630-41-1

NS3623

Purity: ≥95%

Molecular weight: 427.18g/mol

Ref: 54-BUP09740

NS3623

CAS: 343630-41-1

NS3623

Purity: 99+%

Molecular weight: 427.18g/mol

Ref: 54-PC108656

NS 3623

Controlled Product

CAS: 343630-41-1

Applications NS 3623 selectively activates the human ether-a-go-go related gene (hERG) potassium channel which mediates the repolarizing cardiac current IKr. NS 3623 an IKr agonist, cause QT interval prolongation, increasing the risk of dangerous ventricular fibrillations, eventually leading to sudden cardiac death.
References Hansen, R. et al.: J. Cardiovas. Pharmacol., 52, 35 (2008)

Formula: C₁₅H₁₀BrF₃N₆O

Color and Shape: Neat

Molecular weight: 427.179

Ref: TR-N900250

NS3623

CAS: 343630-41-1

NS3623 is a small molecule that blocks the transport of potassium ions in cells by binding to the ATP-sensitive potassium channel. This leads to an increase in intracellular calcium, which causes cell lysis and apoptosis. NS3623 has shown cytotoxic effects on cancer cells in vitro. It also inhibits the growth of k562 cells and has shown to inhibit angiogenesis, as well as stimulate tumor necrosis factor-α (TNF-α) production.

Formula: C₁₅H₁₀BrF₃N₆O

Purity: Min. 95%

Molecular weight: 427.18 g/mol

Ref: 3D-TNA63041