CAS 34367-54-9

pglu-3-methyl-his-pro amide

Description:

Pglu-3-methyl-his-pro amide, identified by its CAS number 34367-54-9, is a synthetic peptide that consists of a sequence of amino acids, specifically proline (Pro), histidine (His), and a modified glutamic acid (Pglu) with a methyl group at the third position. This compound is characterized by its unique structure, which influences its biological activity and interactions. Peptides like Pglu-3-methyl-his-pro amide often exhibit properties such as solubility in polar solvents, potential bioactivity, and the ability to form hydrogen bonds due to the presence of amide linkages. The methylation of the histidine residue can affect its pKa, altering the peptide's charge and reactivity under physiological conditions. Such modifications can enhance stability and influence the peptide's role in biological systems, including potential applications in drug development or as biochemical probes. Overall, the characteristics of this compound make it of interest in fields such as medicinal chemistry and biochemistry.

Formula: C₁₇H₂₄N₆O₄

InChI: InChI=1/C17H24N6O4/c1-22-9-19-8-10(22)7-11(18)17(27)23-6-2-3-13(23)16(26)21-15(25)12-4-5-14(24)20-12/h8-9,11-13H,2-7,18H2,1H3,(H,20,24)(H,21,25,26)/t11-,12-,13-/m0/s1

SMILES: Cn1cncc1C[C@@H](C(=O)N1CCC[C@H]1C(=O)N=C([C@@H]1CCC(=N1)O)O)N

Synonyms:

• Thyrotropin-releasing hormone, 3-Me-
• 3-Me-His(2)trh
• 3-Me-Trh
• 3-Mehis-trh
• 3-Methyl-thyrotropin-releasing hormone
• 3-Methylhistidine-trh
• Pglu-3-Me-his-pro-NH2
• Pyroglu-3-methyl-histidyl-prolinamide
• Pyroglutamyl-3-methylhistidyl-prolinamide
• Thyrotropin-releasing hormone, 3-methyl-
• L-Prolinamide, 5-oxo-L-prolyl-3-methyl-L-histidyl-

(His(3-Me)2)-TRH trifluoroacetate salt

CAS: 34367-54-9

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Formula: C₁₇H₂₄N₆O₄

Purity: Min. 95%

Molecular weight: 376.41 g/mol

Ref: 3D-FH110197