CAS 34381-68-5

Acebutolol hydrochloride

Description:

Acebutolol hydrochloride is a selective beta-1 adrenergic antagonist, primarily used in the treatment of hypertension and certain cardiac conditions. It is characterized by its ability to reduce heart rate and myocardial contractility, making it effective in managing high blood pressure and preventing angina. The compound is typically administered orally and is known for its relatively long half-life, allowing for once or twice daily dosing. Acebutolol hydrochloride is a white to off-white crystalline powder, soluble in water and alcohol, which facilitates its formulation in various dosage forms. Its mechanism of action involves blocking beta-1 receptors in the heart, leading to decreased cardiac output and lower blood pressure. Additionally, it possesses intrinsic sympathomimetic activity, which means it can partially stimulate beta receptors while blocking them, potentially resulting in fewer side effects compared to non-selective beta blockers. As with any medication, it is important to monitor for potential side effects, including bradycardia and fatigue, and to consider contraindications in patients with certain pre-existing conditions.

Formula: C₁₈H₂₉ClN₂O₄

InChI: InChI=1/C18H28N2O4.ClH/c1-5-6-18(23)20-14-7-8-17(16(9-14)13(4)21)24-11-15(22)10-19-12(2)3;/h7-9,12,15,19,22H,5-6,10-11H2,1-4H3,(H,20,23);1H

InChI key: InChIKey=KTUFKADDDORSSI-UHFFFAOYSA-N

SMILES: O(CC(CNC(C)C)O)C1=C(C(C)=O)C=C(NC(CCC)=O)C=C1.Cl

Synonyms:

• (+-)-3'-Acetyl-4'-(2-hydroxy-3-(isopropylamino)propoxy)butyranilide monohydrochloride
• (1)-N-(3-Acetyl-4-(2-hydroxy-3-((isopropyl)amino)propoxy)phenyl)butyramide monohydrochloride
• 3'-Acetyl-4'-(2-hydroxy-3-(isopropylamino)propoxy)butyranilide hydrochloride
• 3-[2-acetyl-4-(butanoylamino)phenoxy]-2-hydroxy-N-(propan-2-yl)propan-1-aminium chloride
• <span class="text-smallcaps">DL</span>-1-(2-Acetyl-4-butyramido)-3-(isopropylamino)propan-2-ol hydrochloride
• <span class="text-smallcaps">DL</span>-1-(2-Acetyl-4-butyramidophenoxy)-2-hydroxy-3-isopropylaminopropane hydrochloride
• Acebutolol HCl
• Acebutolol hydrochloride [JAN]
• Acetanol
• Acetobutolol hydrochloride
• Butanamide, N-(3-acetyl-4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)-, monohydrochloride, (+-)-
• Butanamide, N-[3-acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]-, hydrochloride (1:1)
• Butyranilide, 3'-acetyl-4'-(2-hydroxy-3-(isopropylamino)propoxy)-, monohydrochloride, (+-)-
• Ccris 1102
• Diasectral
• Hsdb 6524
• Il 17803A
• M and B 17803A
• M&B 17,803A
• Neptall
• Sectral
• Unii-B025Y34C54
• Wesfalin
• dl-1-(2-Acetyl-4-butyramidophenoxy)-2-hydroxy-3-isopropylaminopropane hydrochloride
• ACEBUTOLOL HYDROCHLORIDE, IMPURITY IN-[3-ACETYL-4-[(2RS)-3-(ETHYLAMINO)-2-HYDROXYPROPOXY]PHENYL)BUTANAMIDE EP STANDARD
• N-[3-Acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]butanamide Hydrochloride
• n-[3-acetyl-4-[2-hydroxy-3-[(isopropyl)amino]propoxy]phenyl]butyramide hydrochloride
• ACEBUTOLOL HYDROCHLORIDE
• 3’-acetyl-4’-(2-hydroxy-3-(isopropylamino)propoxy)butyranilidehydrochloride
• (±)-N-[3-acetyl-4-[2-hydroxy-3-[(isopropyl)amino]propoxy]phenyl]butyramide monohydrochloride
• ACEBUTOLOL HYDROCHLORIDE, EP STANDARD
• acetobutololhydrochloride
• ACEBUTOLOL HYDROCHLORIDE, USP STANDARD
• Acecor
• 3’-acetyl-4’-(2-hydroxy-3-(isopropylamino)propoxy)-butyranilidmonohydrochl
• m&b17,803a
• ACEBUTOLOL HYDROCHLORIDE, IMPURITY CN-(3-ACETYL-4-HYDROXYPHENYL)BUTANAMIDE EP STANDARD
• dl-1-(2-acetyl-4-butyramidophenoxy)-2-hydroxy-3-isopropylaminopropanehydroch
• N-[3-ACETYL-4-(2-HYDROXY-3-[ISOPROPYLAMINO]PROPOXY)PHENYL]-BUTANAMIDE HYDROCHLORIDE
• ACEBUTOLOL HYDROCHLORIDE, MM(CRM STANDARD)

Acebutolol Hydrochloride

CAS: 34381-68-5

Color and Shape: Neat

Ref: 61-FOR0435.00

Acebutolol Hydrochloride 1.0 mg/ml in Methanol (as free base)

CAS: 34381-68-5

Color and Shape: Single Solution

Ref: 61-AMP0435.00-01

ACEBUTOLOL HYDROCHLORIDE CRS

CAS: 34381-68-5

ACEBUTOLOL HYDROCHLORIDE CRS

Formula: C₉H₁₇NO

Color and Shape: White. Whitish. Crystalline Powder. Powder.

Molecular weight: 155.2374

Ref: 41-A0040000

Acebutolol Hydrochloride

CAS: 34381-68-5

Aromatic cyclic amides (including cyclic carbamates) and their derivatives; salts thereof

Formula: C₁₈H₂₈N₂O₄·HCl

Color and Shape: White Off-White Powder

Molecular weight: 372.89

Ref: 45-1000601

DL-1-(2-Acetyl-4-butyramidophenoxy)-2-hydroxy-3-isopropylaminopropane hydrochloride

CAS: 34381-68-5

Formula: C₁₈H₂₉ClN₂O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 372.8869

Ref: IN-DA007FXT

Acebutolol hydrochloride

CAS: 34381-68-5

Acebutolol HCl: cardioselective beta-blocker, minimal bronchial impact, intrinsic sympathomimetic, treats hypertension & ventricular arrhythmias.

Formula: C₁₈H₂₉ClN₂O₄

Purity: 99.92% - >99.99%

Color and Shape: White Or Slightly Off-White Crystalline Powder Solid

Molecular weight: 372.89

Ref: TM-T1012

Acebutolol-d7

CAS: 34381-68-5, 37517-30-9

Formula: C₁₈H₂₁D₇N₂O₄

Color and Shape: White To Off-White Solid

Molecular weight: 343.47

Ref: 4Z-A-169012

Acebutolol Hydrochloride

CAS: 34381-68-5

Color and Shape: Neat

Ref: 86-MM0435.00

Acebutolol hydrochloride

Controlled Product

CAS: 34381-68-5

Formula: C₁₈H₂₈N₂O₄·ClH

Color and Shape: Off-White

Molecular weight: 372.89

Ref: 04-C10005150

Acebutolol Hydrochloride

CAS: 34381-68-5

Applications Cardioselective β-adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).
References Cuthbert, O.A., et al.: Br. J. Pharmacol., 43, 639 (1971), Singh, B.N., et al.: Drugs, 29, 531 (1985), Foster, R.T., et al.: Anal. Profiles Drug Subs., 19, 1 (1990),

Formula: C₁₈H₂₉ClN₂O₄

Color and Shape: White to Pale Yellow Solid

Molecular weight: 372.89

Ref: TR-A123800

Acebutolol hydrochloride

Controlled Product

CAS: 34381-68-5

Acebutolol is a non-selective beta-blocker that is used for the treatment of hypertension and other conditions. It inhibits the ryanodine receptor and prevents calcium release, which has been shown to be responsible for the contraction of cardiac muscle. Acebutolol also inhibits phosphodiesterase, which leads to increased levels of cyclic adenosine monophosphate (cAMP) in cells. In addition, acebutolol has been shown to inhibit the production of inflammatory mediators by inhibiting prostaglandin synthesis. The most common adverse effects include drowsiness, dizziness, fatigue, and headache. Acebutolol hydrochloride can be found in wastewater as a result of its use in humans and animals. This drug can be detected in wastewater using solid phase microextraction followed by gas chromatography/mass spectrometry (GC/MS).

Formula: C₁₈H₂₈N₂O₄•HCl

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 372.89 g/mol

Ref: 3D-FA16907

Acebutolol hydrochloride

CAS: 34381-68-5

Cardioselective beta-adrenergic blocker This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Formula: C₁₈H₂₈N₂O₄•HCl

Color and Shape: Powder or crystals or crystalline powder, White to off-white

Molecular weight: 372.89

Ref: 02-J63790