CAS 34444-01-4

Cefamandole

Description:

Cefamandole is a semisynthetic antibiotic belonging to the cephalosporin class, specifically the second generation. It is primarily used to treat a variety of bacterial infections, particularly those caused by Gram-negative and some Gram-positive organisms. Cefamandole exhibits a broad spectrum of activity, making it effective against pathogens such as Escherichia coli and Klebsiella species. The compound works by inhibiting bacterial cell wall synthesis, leading to cell lysis and death. It is typically administered via injection and is known for its relatively good tissue penetration. Cefamandole is characterized by its beta-lactam structure, which is essential for its antibacterial activity. However, it may cause allergic reactions in individuals with a history of penicillin allergies due to structural similarities. Common side effects can include gastrointestinal disturbances and potential alterations in liver function tests. As with other antibiotics, it is crucial to use cefamandole judiciously to prevent the development of antibiotic resistance.

Formula: C₁₈H₁₈N₆O₅S₂

InChI: InChI=1S/C18H18N6O5S2/c1-23-18(20-21-22-23)31-8-10-7-30-16-11(15(27)24(16)12(10)17(28)29)19-14(26)13(25)9-5-3-2-4-6-9/h2-6,11,13,16,25H,7-8H2,1H3,(H,19,26)(H,28,29)/t11-,13-,16-/m1/s1

InChI key: InChIKey=OLVCFLKTBJRLHI-AXAPSJFSSA-N

SMILES: C(O)(=O)C=1N2[C@@]([C@H](NC([C@H](O)C3=CC=CC=C3)=O)C2=O)(SCC1CSC=4N(C)N=NN4)[H]

Synonyms:

• (6R,7R)-7-[[(2R)-2-Hydroxy-2-phenylacetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6R,7R)-7-{[hydroxy(phenyl)acetyl]amino}-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 3-(1-Methyltetrazol-5-ylthiomethyl)-7-<span class="text-smallcaps">D</span>-mandelamido-3-cephem-4-carboxylic acid
• 3-(1-Methyltetrazol-5-ylthiomethyl)-7-D-mandelamido-3-cephem-4-carboxylic acid
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[(hydroxyphenylacetyl)amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, [6R-[6α,7β(R*)]]-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-2-hydroxy-2-phenylacetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, (6R,7R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-hydroxyphenylacetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, (6R,7R)-
• <span class="text-smallcaps">L</span>-Cefamandole
• CMT
• Cefadole
• Cefamandol
• Cephadole
• Cephamandole
• L-Cefamandole
• Mandol
• sodium 7-{[(formyloxy)(phenyl)acetyl]amino}-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Cefamandole

CAS: 34444-01-4

Cefamandole

Purity: ≥98%

Molecular weight: 462.5g/mol

Ref: 54-BUP21471

Cefamandole

CAS: 34444-01-4

Formula: C₁₈H₁₈N₆O₅S₂

Color and Shape: Off-White Solid

Molecular weight: 462.50

Ref: 4Z-C-162011

Cefamandole

CAS: 34444-01-4

Cefamandole is a broad-spectrum cephalosporin antibiotic with antibacterial activity against Bacillus subtilis and Escherichia coli.

Formula: C₁₈H₁₈N₆O₅S₂

Purity: 99.38%

Color and Shape: Solid

Molecular weight: 462.5

Ref: TM-T20196