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CAS 34493-98-6

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Dibekacin

Description:
Dibekacin is an aminoglycoside antibiotic that is primarily used in the treatment of serious infections caused by Gram-negative bacteria. It is particularly effective against strains that are resistant to other antibiotics. The chemical structure of dibekacin features a complex arrangement of amino sugars, which contributes to its mechanism of action by inhibiting bacterial protein synthesis. This antibiotic is typically administered via injection due to its poor oral bioavailability. Dibekacin exhibits a broad spectrum of activity, making it valuable in clinical settings, especially for patients with compromised immune systems. However, like other aminoglycosides, it carries the risk of nephrotoxicity and ototoxicity, necessitating careful monitoring of renal function and hearing during treatment. Its use is often reserved for specific cases where other antibiotics may not be effective, and it is important to consider susceptibility testing to ensure its efficacy against the targeted pathogens. Overall, dibekacin represents a critical option in the arsenal against multidrug-resistant bacterial infections.
Formula:C18H37N5O8
InChI:InChI=1S/C18H37N5O8/c19-4-6-1-2-7(20)17(28-6)30-15-8(21)3-9(22)16(14(15)27)31-18-13(26)11(23)12(25)10(5-24)29-18/h6-18,24-27H,1-5,19-23H2/t6-,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+/m0/s1
InChI key:InChIKey=JJCQSGDBDPYCEO-XVZSLQNASA-N
SMILES:O([C@@H]1[C@@H](O)[C@H](O[C@H]2O[C@H](CN)CC[C@H]2N)[C@@H](N)C[C@H]1N)[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O
Synonyms:
  • (1R,2S,3S,4R,6S)-4,6-diamino-3-[(3-amino-3-deoxy-alpha-D-glucopyranosyl)oxy]-2-hydroxycyclohexyl 2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranoside
  • (1R,2S,3S,4R,6S)-4,6-diamino-3-[(3-amino-3-deoxy-alpha-D-glucopyranosyl)oxy]-2-hydroxycyclohexyl 2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranoside sulfate (1:1)
  • (2R,3R,4S,5S,6R)-4-Amino-2-[(1S,2S,3R,4S,6R)-4,6-Diamino-3-[(2R,3R,6S)-3-Amino-6-(Aminomethyl)Oxan-2-Yl]Oxy-2-Hydroxy-Cyclohexyl]Oxy-6-(Hydroxymethyl)Oxane-3,5-Diol
  • 3',4'-Dideoxykanamycin B
  • 3′,4′-Dideoxykanamycin B
  • 4,6-Diamino-3-[(3-Amino-3-Deoxyhexopyranosyl)Oxy]-2-Hydroxycyclohexyl 2,6-Diamino-2,3,4,6-Tetradeoxyhexopyranoside
  • <span class="text-smallcaps">D</smallcap>-Streptamine, O-3-amino-3-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-<smallcap>D</span>-erythro-hexopyranosyl-(1→4)]-2-deoxy-
  • Brn 1441606
  • D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-O-(2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranosyl)-(1-4)-2-deoxy-
  • DKB
  • See more synonyms
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